Ariel K. Frame
@arielframe.bsky.social
BSc Biology || PhD Neuroscience || Postdoc with Andrew Lin @andrewclin.bsky.social at University of Sheffield @sheffielduni.bsky.social || Drosophila, aging, learning and memory, neurobiology. Host: linktr.ee/quitecurious bit.ly/ArielFrame_GoogleScholar
Newest episode of Quite Curious featuring Mikko Juusola! We talk about #electrophysiology in eyes of #flies Musca domestica showing #synapse jumping at such high frequency that it brings into question what the minimum delay is between sensing and reality. Take a listen! linktr.ee/quitecurious
What does it really take to land a faculty position? @jazlynmooney.bsky.social shares insights on preparing competitive applications, navigating interviews, building a research vision, and more. 🔗: buff.ly/nLWXT9m
Phenomena such as blindsight remind us that intelligent, even emotionally attuned behavior does not imply conscious experience or genuine agency, write Vanessa Hadid, @karimjerbi.bsky.social and John W. Krakauer. #neuroskyence www.thetransmitter.org/artificial-i...
The illusion of AI consciousness: Lessons from humans
Complex, goal-directed and emotionally responsive behavior can unfold without awareness, providing a useful lens for interpreting artificial systems.
thetransmitter.org
#Drosophila #neuroscience researchers you still have time to make it for early bird registration and abstraction submission deadline for #neurofly 2026 - it’s June 7th. neurofly.org See all you #fly folks there!
This is really bad for #science. It’s vital for #researchintegrity that scientists commit to ensuring all citations are real & correctly cited. If AI finds papers, it’s crucial to double check them. www.thelancet.com/journals/lan...
Fabricated citations: an audit across 2·5 million biomedical papers
Scientific literature depends on the integrity of its references. Each reference implicitly asserts that a verifiable source exists and supports the claims being made. When references point to non-exi...
thelancet.com
Johns Hopkins Berman Institute of Bioethics@bermaninstitute.bsky.social · 3mo agoSurge in fake citations uncovered by audit of 2.5 million biomedical science papers. An analysis of 97 million citations has found that rates of fabricated citations have climbed steeply since 2023. www.nature.com/articles/d41...
Mitochondria-lysosome coupling contributes to lysosome acidification and aging: Molecular Cell www.cell.com/molecular-ce...
Mitochondria-lysosome coupling contributes to lysosome acidification and aging
While classical models propose that lysosomes/vacuoles are acidified using free cytosolic protons, Liu et al. reveal that mitochondrial electron transport provides a substantial proton source through ...
cell.com
Fuck no. medicalnewsbulletin.com/mosquitoes-c... 🧪 #evosky 🩸🧪 medsky, 🩺,⚕️ #Neuroscience, #Neuroskyence SciNews
Mosquitoes might know there’s a human under the smell of DEET | Medical News Bulletin
Scientists say that mosquitoes are figuring out that where there’s DEET, there’s meat. Learn what the heck is going on with MNB.
medicalnewsbulletin.com
Calling #Drosophila #neuroscience researchers! Listen to @andrewclin.bsky.social @sheffielduni.bsky.social speak on 2 @jphysiol.bsky.social fly papers: #brain #mushroombody #homeostaticplasticity, #genetic #neuron tools, NaChBac advice, & #mathematicalmodelling tiny.cc/qcu2 #sciencecommunication
This is another one of those studies I really want to hear the story behind. You don't just go "I wonder, what would happen if we keep some fruit flies at 7Gs for a while?" 🧪 (They don't like it first, but seem to adapt) Link: https://doi.org/10.1242/jeb.251327
![Hypergravity induces impairment in adult Drosophila melanogaster negative geotactic behavior. (A) A custom-built hypergravity simulator consisting of a circular plate attached to an AC motor via a rotating shaft. (B) Experimental timeline for assessing negative geotaxis following acute hypergravity exposure. SING, startle-induced negative geotaxis. (C) Climbing score on days 1–7, calculated as the proportion of flies that climbed 15 cm within 5 s [mean±s.e.m., generalized linear mixed model, GLMM, n=34 (1 g), n=32 (4 g); n=30 (1 g), n=29 (7 g); n=30 (1 g), n=28 (10 g); n=30 (1 g), n=30 (13 g)]. (D) Total distance moved within 5 min in the absence of startle stimuli at 0, 2 and 24 h post-hypergravity treatment [means±s.e.m., mixed-effects model, n=30 (1 g); n=29 (4 g); n=29 (7 g); n=30 (10 g); n=28 (13 g)]. (E) Mean velocity of flies over 5 min in the absence of startle stimuli at 0, 2 and 24 h post-hypergravity treatment [means±s.e.m., mixed-effects model, n=30 (1 g); n=29 (4 g); n=29 (7 g); n=30 (10 g); n=28 (13 g)]. For C–E: 1 g control flies (blue), 4 g (yellow), 7 g (red), 10 g (burgundy) and 13 g (purple). (F) Representative individual trajectories for flies in the negative geotaxis assay in the absence of startle stimuli at 0 and 24 h post-hypergravity treatment [individual control (blue) and hypergravity-exposed (other colors)]. Data represent biologically independent samples from three trials. All statistical tests were two-tailed. False discovery rate (FDR) correction was applied for multiple comparisons. Asterisks denote statistically significant differences between hypergravity-exposed flies and 1 g controls (*P<0.05; **P<0.01; ***P<0.001).](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:ywwbhwuq4sszjve7kdshnahd/bafkreiftggfqgq73bx6kf72wtjwnaur2hwhqvgi6ly5rbo7hobminffyly)
Selecting an effect size for power analysis is hard. Many researchers fall back on Cohen's thresholds, but they have no empirical basis and vary wildly by field. Our new paper offers a better option: field-specific effect size distributions built from meta-analytic data doi.org/10.3758/s134...
PhD Opportunity! 4-year funded PhD @uniexecec.bsky.social: “From cognition to conservation: using cognitive and behavioural research to enhance animal reintroductions”. Closes: 5 June 2026. Funding: @royalsociety.org (UK/Home students only). More info & to apply: www.exeter.ac.uk/study/fundin... 1/
From cognition to conservation: using cognitive and behavioural research to enhance animal reintroductions, PhD (Funded) | University of Exeter
The University of Exeter’s Centre for Ecology and Conservation, Penryn Campus, Cornwall, is inviting applications for a 4-year PhD studentship (UK fees), ideally commencing Sept 2026.
exeter.ac.uk
Sounds like a very useful new method to me! I’m always intrigued by new and improved balancers too. I think I might even go ahead and order your new 4th balancer from @bdsc.bsky.social now! BDSC #90851 + #90852
Fillip Port@crisprflydesign.bsky.social · 4mo agoChasing donor backbone insertions in #CRISPR knock-in experiments is a great way to waste an afternoon (or more), unless you use a dominant marker. We like this one from the Carthew lab, in which animals containing the backbone have degenerated eyes: www.tandfonline.com/doi/full/10.... #Drosophila
Beyond delighted to share our amazing collaboration with Thierry Alquier's lab @alquierthierry.bsky.social on a conserved role for neuronal lipid droplets in regulating energy homeostasis in vivo led by Celena Cherian, Romane Manceau, Danie Majeur, and Colin Miller www.nature.com/articles/s42... /1
Neuronal lipid droplets play a conserved and sex-biased role in maintaining whole-body energy homeostasis - Nature Metabolism
In vivo regulation of neuronal lipid droplet formation mediates whole-body energy homeostasis in a sex-specific manner in Drosophila and mice.
nature.com
What do The Bee Gees and bumblebees have in common? Both bees have rhythm!🕺🪩🐝 check out this new paper where authors show that bumblebees can discriminate rhythms across sensory modalities! www.science.org/doi/10.1126/...
Flexible, abstract rhythm perception in bumble bees
Flexible, abstract rhythm perception underpins human music, dance, and speech, but thus far, it has only been demonstrated in a few birds and mammals. In this work, we show that bumble bees also form ...
science.org
I nearly died when @tspiresjones.bsky.social and @janetulloch.bsky.social surprised us with this complete *YEAR LONG* study at our lab meeting. academic.oup.com/braincomms/a...
In this new study, @dogagingproject.bsky.social identified overlapping metabolites linked to a subset of dogs and human mortality, supporting dogs as a compelling model for studying human aging. doi.org/10.1093/gero... @academic.oup.com
Aging may feel gradual… but what if it’s not? In our recent paper, we tracked fish continuously from puberty until death. This gave us a unique view of how aging unfolds across the adult lifespan. 🧵
Very cool! Useful tool for #Drosophila folks. Would be great adopted by whole labs / institutions. Considering it's newness, add features? Tinkering & I don't yet see: 1) Retrospective dating / bulk stock flipping 2) Stock acquisition date 3) Column sort by chromosome 4) Reference usage citation
flyroom.net@flyroom.net · 5mo agoWe just launched flyRoom — modern web-based stock management for Drosophila labs. No more spreadsheets, no more messy labels, no more lost stocks. Free to start, built by researchers for researchers. www.flyroom.net
This #InternationalWomensDay I want to tell the story of Lilian Vaughan Morgan. I learned of Lilian this past year - what a badass. Lilian was a leading scientist when women weren't welcome in the lab, nor even the department. But she contributed immensely to the genetics of sex determination 1/n
Quick plug for our new resource, the Drosophila Species Stock Exchange. This is a database and mailing list that documents species currently in culture and the labs holding them. If you want to know more or sign up then please get in touch. See attached for more info and please share!
Conflicting adaptations in an inhibitory feedback circuit #Drosophila
Conflicting adaptations in an inhibitory feedback circuit #Drosophila
PubMed link
pubmed.ncbi.nlm.nih.gov
I love these micropublications. Great way to disseminate small but impactful findings. This #drosophila study shows glutamate neurons w/ reduced ATP production related #mitochondria protein causes more day #sleep at young and after #aging. Could this explain lifespan extension (Keppley et al. 2018)?
microPublication Biology@micropub7n.bsky.social · 5mo agoReduced expression of the electron transport chain component ATPsynβL in glutamate neurons changes Drosophila melanogaster sleep patterns through adulthood. #micropublication #biology #data #caltechli https://micropublication.org/journals/biology/micropub-biology-002033
Thank you so much for generating these lines! Exciting new tools for #drosophila optogenetic activation of the Gal4 UAS system! Drosophilists rejoice: here’s the list of lines->
Alex Gould Lab@alexgouldlab.bsky.social · 5mo ago#Drosophila calling. Delighted to share our new collection of ShineGAL4 drivers for CNS, FB, muscles, enterocytes, oenocytes and MTs made by @vgirard.bsky.social, @sebsorge.bsky.social and colleagues @crick.ac.uk. All at Bloomington @bdsc.bsky.social @dev-journal.bsky.social tinyurl.com/4jpw9jd6
Very cool #drosophila study! The potential uses for this technology are endless!
Vanessa Enriquez-Rios@pt007.bsky.social · last yr.
For all #Drosophila #neuroskyence researchers that have explained to someone, yes #insects have #brains: Here is @scottishwaddell.bsky.social & Annie Park's excellent argument for four 'cognitive primitives' underlying fundamental brain function conserved from humans to flies. tiny.cc/4cog
I’ve really been enjoying this podcast since it started a few months ago: The Rest is Science. tiny.cc/restsci Professor Hannah Fry and VSauce's Michael Stevens are amazing at #sciencecommunication Highly recommend! Even better: partners with a good cause @cancerresearchuk.org
This is a superb explanation of why we age from an evolutionary perspective, packed full of fun animal examples! It makes clear that evolution *did* optimise for lifespan (why wouldn’t it?), and that implies intervening in aging might not be that hard…
Why we age
Three categories of explanations exist for why we age: mechanistic theories, which omit reference to evolutionary forces; weakening force of selection theories, which posit that barriers exist that p...
onlinelibrary.wiley.com
MRC Laboratory of Molecular Biology Cambridge seeks a Postdoctoral Researcher to develop amyloid filament methods using cryo EM to study tau neurodegeneration. Closing date: 4th January www.dementiaresearcher.nihr.ac.uk/job/postdoct...
Postdoctoral Scientist: Neurobiology - DEMENTIA RESEARCHER
MRC Laboratory of Molecular Biology Cambridge seeks a Postdoctoral Researcher to develop amyloid filament methods using cryo EM to study tau neurodegeneration.
dementiaresearcher.nihr.ac.uk
@nature.com asked me to write an op-ed on the perspective of the AI reviewing process, prompted by the recent partnership between @biorxivpreprint.bsky.social and @qedscience.bsky.social Hope my perspective adds value to the conversation. www.nature.com/articles/d41...
AI reviewers are here — we are not ready
Artificial intelligence promises rapid and polite feedback on papers — but we must first review the reviewer.
nature.com
Encased in a blanket of blubber that is nearly half a metre thick, the 80,000-kilogram bowhead whale does not, at first glance, seem a natural poster child for health and longevity go.nature.com/4qTyrcz
This whale lives for centuries: its secret could help extend human lifespan
Nature - A cold-activated protein that mends damaged DNA could play a part in keeping the bowhead whale in tip-top shape.
go.nature.com