Matt Webster

@mwbstr.bsky.social

Evolution and population genetics https://www.websterlab.net/

The exciting next instalment of Mutations in Time and Space... Open for registration now

Wellcome Connecting Science Learning and Training@eventswcs.bsky.social · 11mo ago

Explore the origins, patterns and consequences of mutations across biological systems! #MITS26 🗓️ Conference dates: 13-15 April 2026 Participate in expert-led knowledge exchange on how genome evolution shapes human health and ageing 🧬 Check out our exciting speakers ➡️ bit.ly/4hmbnyr #Genomics

Wellcome Connecting Science hybrid conference 
Mutations in Time and Space

Conference dates: 13-15 April 2026 
Location: Hinxton Hall Conference Centre, UK and online. 

Bursary deadline: 12 January 2026
Abstract deadline: 2 February 2026
In-person registration deadline: 16 March 2026
Virtual deadline: 6 April 2026

Latest research from the lab where we mapped the sex-determining gene in the red mason bee. Surprisingly it turned out to be the same gene used by ants, suggesting an ancient origin >150 million years ago. Thanks to the many people involved!

PLOS Biology@plosbiology.org · 10mo ago

#Haplodiploid inheritance is found in all species of #Hymenoptera. @mwbstr.bsky.social &co map the #sex determining #gene of the red mason #bee to the ANTSR gene region, suggesting a shared, ancient origin of #SexDetermination in bees & ants >150 Mya ago @plosbiology.org 🧪 plos.io/47COEtH

Complementary sex determination (CSD) in bees and ants. Top left: Single-locus CSD is likely to be the predominant mode of sex determination in Hymenoptera. CSD loci have been identified in two species: the honeybee Apis mellifera and the invasive ant Linepithema humile. The tree shows evolutionary relationships between these species and Osmia bicornis, the main subject of this study. The origin of Hymenoptera is estimated as 386 million years ago and the common ancestor of Apoidea and Formicoidea is estimated as 153 million years ago. Top right: Under single-locus CSD, females are heterozygous at the CSD locus, whereas males are haploid and therefore hemizygous. A large number of CSD alleles are expected to segregate in outbred populations. A small proportion of homozygotes at the CSD locus are produced by chance, when parents share an allele, which results in the production of sterile diploid males. Middle: An O. bicornis nest consists of a row of cocoons in a tube. The mother lays fertilized diploid eggs deepest in the nest and unfertilized haploid eggs closer to the entrance. Eggs develop into adults inside cocoons. Diploid eggs typically develop into females whereas haploid eggs become male. A small proportion of diploids that are homozygous at the CSD locus develop into diploid males, which occur amongst females and are larger than haploid males. Bottom: A male and female red mason bee mating. Photo by Marie Louise Huskens.

I'm happy to share our new study where we mapped the sex-determining locus in the red mason bee. It maps to the ANTSR lncRNA discovered in ants, suggesting that this gene determines sex widely in Hymenoptera. www.biorxiv.org/content/10.1...

Genetic mapping in the red mason bee Osmia bicornis implicates ANTSR as an ancient sex-determining locus in bees and ants

Haplodiploid inheritance, in which females are diploid and males are haploid, is found in all species of Hymenoptera. Sex in haplodiploids is commonly determined by the alleles present at a complementary sex determination (CSD) locus, with heterozygosity triggering the female developmental pathway. The identity of this locus differs among taxa and is only known in a few species. Here, we map a single CSD locus to a 2 kbp region in the genome of the red mason bee Osmia bicornis . It overlaps the long noncoding RNA ANTSR , which has been identified as the sex-determining gene in the invasive ant Linepithema humile . This locus is homozygous in diploid males and exhibits extremely high levels of haplotype diversity, consistent with the action of frequency-dependent selection. The elevated levels of heterozygosity in the CSD locus enable us to fine-map potentially functional genetic variation within it. We also identify elevated levels of genetic diversity in the ortholog of the CSD locus in other bee genera, suggesting that it may govern sex determination widely in bees. Our data are consistent with the hypothesis that ANTSR evolved a role in sex determination at least 150 million years ago and is the ancestral sex-determination locus of bees and ants. ### Competing Interest Statement The authors have declared no competing interest. Erik Philip-Sörensens Stiftelse Swedish Research Council, 2022-06725

biorxiv.org

NOBEL SYMPOSIA We are delighted to announce two exciting public talks on Ancient DNA at Aula Magna (Stockholm University) on May 30th, 10:00-12:30h. 🦣⬅️ ”Can we bring back the woolly mammoth?” by Beth Shapiro. 🐎✋”The taming of the horse” by Ludovic Orlando. Free entrance. All welcome!

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We have an open 4-year PhD position in the Slotte lab at Stockholm University, to investigate genomic signatures of selection associated with pollination mode shifts. Full ad: su.varbi.com/en/what:job/... Apply by April 22, 2025 via the University application portal (link). Please repost! 🧪

PhD student in Ecology and Evolution

The Department of Ecology, Environment and Plant Sciences (DEEP) is located in the Arrhenius Laboratories, situated at the University Campus at Frescati. Presently around 100 people, including 35 PhD

su.varbi.com