🚨 Our new review is out! What makes a circular RNA actually functional? We revisit Cdr1as/ciRS-7, one of the most studied circular RNAs, and bring together 15+ years of work to understand what makes it functionally unique. Check it out here 👇 www.nature.com/articles/s41...

The history and function of a circular RNA - Nature Communications

In this paper, the authors review how the circular RNA Cdr1as and its interacting non-coding RNAs regulate neuronal stress responses and synaptic activity, highlighting general principles of RNA-based...

nature.com

Our most recent work on the “function and evolution” of #nuclear-speckles is now online at Cell @cp-cell.bsky.social doi.org/10.1016/j.ce... Read the thread👇 for the highlights of our findings.

oh wow so accurate 🥹

Oded Rechavi@odedrechavi.bsky.social · 10mo ago

Trying to log into Eduroam

🥳 Very grateful for the support of the ERC Starting Grant for my newly established lab! We will study how transposable elements contribute to mammalian embryonic development. We will have positions available next year. Stay tuned!

European Research Council (ERC)@erc.europa.eu · 11mo ago

📣 The ERC Starting Grant call results are out! Find out which early-career researchers will receive funding this year, what they will be investigating, where they will be based... plus lots of other #ERCStG facts & figures for 2025! ➡️ buff.ly/IsafuFh #FrontierResearch 🇪🇺#EUfunded #HorizonEurope

It's that time of the year - @mdc-berlin.bsky.social Pride Symposium in its 4th edition with great talks and discussions on intersectionality and DEI in general. As Neil Young said on Waldbuehne the other day - "Times are rough, we gotta look out for each other" 🫶 #MdcDiversity

Finally out! 🥳 Our paper showing how a transposable element (TE) insertion can cause developmental phenotypes is now published @natgenet.nature.com 🧬🦠🐁 Below is a brief description of the major findings. Check the full version of the paper for more details: www.nature.com/articles/s41588-025-02248-5

Enhancer adoption by an LTR retrotransposon generates viral-like particles, causing developmental limb phenotypes - Nature Genetics

Activation of an LTR retrotransposon inserted upstream of the Fgf8 gene produces viral-like particles in the mouse developing limb, triggering apoptosis and causing limb malformation. This phenotype c...

nature.com

We wrote a review on Transposable Elements (TEs) and almost all aspects of TE silencing and their roles in biological processes & disease. www.nature.com/articles/s41...

Transcriptional and post-transcriptional regulation of transposable elements and their roles in development and disease - Nature Reviews Molecular Cell Biology

Transposable elements (TEs) comprise nearly half of the human genome. This Review discusses transcriptional and post-transcriptional mechanisms that repress TE activity, how TEs escape this suppressio...

nature.com

Insights from #TCTeAC

the Node@the-node.bsky.social · last yr.

From Posters to Parades: Inside Woodstock.Bio² & Night Science Conference @natanellae.bsky.social gives us a glimpse of what happened during #TCTeAC @woodstocknightsci.bsky.social 👀🎵💃 thenode.biologists.com/from-posters...

this is happening! ☀️

Max Planck Institute of Immunobiology and Epigenetics@mpi-ie.bsky.social · last yr.

We are excited to officially welcome a new group leader at the MPI-IE in #Freiburg. 🎉 Dr Juliane Glaser 🥳 – she studies epigenetic mechanisms of embryonic development, with a focus on transposable elements. 👉 Interview: www.ie-freiburg.mpg.de/6043545/2025... Welcome, @julianeg.bsky.social!

I am heartbroken about the loss of many labs at the Weizmann Institute yesterday in the missile attack. Dear scientists there: please know that you are not alone. Like many many others, I support you and am standing by to help you in any way I can.

#TCTeAC ... The Woodstock of Biology2 & Night Science was terminated by police arrival. >The End< Nobody apparently dared to take a picture but it's true.

vibing with my gang on woodstock night science conference, day 3 #theconferencetoendallconferences #TCTeAC

getting killed five seconds into the assasin game with 144 participants because your partner got you as a target #TCTeAC

a bald man wearing a plaid shirt and a black vest

ALT: a bald man wearing a plaid shirt and a black vest

media.tenor.com

🔥🔥🔥

Helena Klara Jambor@helenajambor.bsky.social · last yr.

#TCTeAC brought more stickers for day2, find the girl with the lipstick 💄 to get yours! 😉

People at home following the Woodstock of Biology treads #theconferencetoendallconferences #TCTeAC

meeting old comrades at #TCTeAC day 1

What controls condensate composition and function beyond binding stoichiometry? We show that condensate microenvironments play a key role, and can be probed by a micropeptide killswitch in live cells. www.nature.com/articles/s41... in @nature.com ‬ with @yaotianzhang.bsky.social Denes Hnisz & team.

How to find Evolutionary Conserved Enhancers in 2025? 🐣-🐭 Check out our paper - fresh off the press!!! We find widespread functional conservation of enhancers in absence of sequence homology Including: a bioinformatic tool to map sequence-diverged enhancers! rdcu.be/enVDN github.com/tobiaszehnde...

Conservation of regulatory elements with highly diverged sequences across large evolutionary distances

Nature Genetics - Combining functional genomic data from mouse and chicken with a synteny-based strategy identifies positionally conserved cis-regulatory elements in the absence of direct sequence...

rdcu.be

I think at this point I am moslty learning new biology from Jordi's memes 🔥🔥

Jordi Solana@jordisolana.bsky.social · last yr.

Proud to present the peer-reviewed version of our Cell Type Allometry paper, out today in Science Advances! www.science.org/doi/10.1126/... Are animals of different sizes made of the same cell types? Here’s an update of the main points and revision items (with memes!) Thread 👇🧵

Sequencing reads get longer, aligners get faster, LLMs get smarter, Katy Perry goes to space, but I still cannot type RNase without autocorrect making it weird.

Our 3D study of the tumor microenvironment is finally out! Play around with the data yourself at lung-3d-browser.mdc-berlin.de (Kudos to @danilexn.bsky.social👏 ) Many thanks to Nikolaus Rajewsky lab at @mdc-bimsb.bsky.social and everyone involved, it takes a village to raise a multimodal paper!

Bita Moghaddam@bita137.bsky.social · last yr.

FDA plans to phase out animal testing requirement for drug testing and replace it with “AI-based computational models of toxicity” and organoid toxicity testing www.fda.gov/news-events/...

And on other news. My first contribution to science as a postdoc with @stirlingchurchman.bsky.social is out! We discuss the knowns and unknowns of post-transcriptional splicing. It was really fun to write with the great @karinechoquet

Nature Reviews Genetics@natrevgenet.nature.com · last yr.

New online! The regulation and function of post-transcriptional RNA splicing

🪄✨

Oded Rechavi@odedrechavi.bsky.social · last yr.

Who does that? We rented a train JUST for the conference, that will take the participants from Prague to the woods of Bohemia. There'll be talks ON THE TRAIN. In Prague we'll have 5 locations with different atmospheres. #theconferencetoendallconferences Register now: woodstock.img.cas.cz