In Wiley Advanced Science @mariesabatier.bsky.social, @ubellackerlab.bsky.social, and colleagues examine GPX4 inhibitor resistance in triple-negative breast cancer, showing that resistant cells survive in circulation but lose the ability to spontaneously metastasize from primary tumors. hsph.me/GPX4

Happy to see our News & Views is out! We highlight two landmark papers demonstrating the potential for therapeutic targeting of FSP1 and #ferroptosis in in vivo cancer models. Beautiful work from @ubellackerlab.bsky.social, Thales Papagiannakopoulos, and colleagues. 🥳 www.nature.com/articles/s41...

In vivo models bring FSP1 inhibitors to life - Nature Cell Biology

FSP1 is a key suppressor of lipid peroxidation and ferroptosis, yet it is largely dispensable in standard cell culture models. Two new studies now show that FSP1 becomes essential for tumour growth in...

nature.com

Excited to share my postdoctoral work, out today in Nature! www.nature.com/articles/s41... We discovered that melanoma cells in lymph nodes gain a targetable FSP1 dependency that limits melanoma progression.

Lymph node environment drives FSP1 targetability in metastasizing melanoma - Nature

Targeting FSP1 in lymph nodes has considerable potential for blocking melanoma progression.

nature.com

Excited to share our work @nature.com! Postdoc @mariopalma.bsky.social, with major contributions from @retickerflynn.bsky.social and collaborators, discovered melanoma cells in lymph nodes gain a targetable FSP1 dependency that limits progression. #TeamFSP1 www.nature.com/articles/s41...

Hot off the presses! Was an honor to team up with Scott Dixon @stanforduniversity.bsky.social on this Nature Cancer review. We reflect on hurdles that have slowed translation of ferroptosis-directed therapies and share ideas on what it will take to bring these therapies to the clinic. rdcu.be/eBbqV

Prospects for ferroptosis therapies in cancer

Nature Cancer - Ubellacker and Dixon summarize the latest discoveries on ferroptosis in cancer, covering the molecular and cellular pathways underlying sensitivity and resistance to this type of...

rdcu.be

Harvard Molecular Metabolism@met-hsph.bsky.social · 12mo ago

Ferroptosis-targeting therapies in cancer have yet to make it to the clinic. New review published today in Nature Cancer by @ubellackerlab.bsky.social and Scott Dixon of Stanford share hurdles and ideas for future strategies to bring these therapies closer to the clinic. Check it out rdcu.be/eBbqV

Interested in studying lymph node metastasis? Check out our protocol by Cort Breuer out today in @natprot.nature.com bsky.app/profile/nat...

Join me in Boston October 6th for a 1-day conference on #mappingbiology to transform #cancertherapeutics. Register by September 25th to benefit from the complimentary (free) admission! Topics, speakers, and talk opportunities here: abcam.me/mappingbiolo... @abcamofficial.bsky.social

Thanks to James Olzmann and Scott Dixon for organizing a fantastic #faseb #ferroptosis meeting in Scottsdale AZ! Lots of great science as ferroptosis continues to impact diverse biology and diseases. Can’t wait for the next one! @olzmannlab.bsky.social

Grateful to mark ULab’s 3rd birthday surrounded by brilliant minds and a deep sense of belonging. In a time of shifting priorities in academia, I’m especially thankful for the inclusive leadership and unwavering support of my incredible PI, Jessalyn @ubellackerlab.bsky.social

Ubellacker Lab@ubellackerlab.bsky.social · last yr.

It’s over 100°F in Boston, and though both the weather and funding climates are intense, we took a well-deserved ice cream break to celebrate the progress, and the incredible people past and present, behind it all. Happy 3rd birthday, ULab! 🎉

Way-to-go Alanis Carmona and Lewis Hendrianto for your incredible posters today at the Landry Cancer Biology Consortium, and shout-out to Alanis on your Karin Grunebaum Cancer Research Foundation Rising Young Scientist Award!

Harvard Chan scientists participate in a rigorous application process for federal grants to conduct their vital health research. The government has now terminated nearly every single one of those grants.

With nearly all of Harvard Chan School’s direct federal grants terminated, we are relying on philanthropy to power our research and support our educational programs. Every gift, regardless of size, advances our vision of health, dignity, and justice for every human. Support our work: hsph.me/whygive

Join us June 2, 3-4PM off the Harvard Longwood Quad for two great cell death discussions on ferroptosis in breast cancer metastasis from @mariesabatier.bsky.social (Ubellacker Lab) and on thiol-reductive stress from Maolin Ge (Bar-Peled Lab)

new out in Nature, very cool story www.nature.com/articles/s41...

Activation of lysosomal iron triggers ferroptosis in cancer - Nature

Some cancer cells exhibit high loads of reactive iron in lysosomes, and this feature is exploited by using fentomycin-1, a newly developed small molecule, to induce ferroptosis.

nature.com

A reminder that for next month’s BCDI in place of our regular discussion, we encourage you to attend the Cutter Distinguished Lecture @met-hsph.bsky.social by the great Scott Dixon! See you there: Monday May 12, 2025, Kresge Building at HSPH, G1 auditorium, 12:00-1:00pm

🌟 Excited to share our latest spotlight! 🌟 Co-wrote with @mariopalma.bsky.social and Jessalyn @ubellackerlab.bsky.social, highlighting Ueda et al.'s study on oxidative niches driving immune evasion in tumors. Check out our spotlight article here: rb.gy/zi8wj9 Ueda et al., 2025: rb.gy/674im7

From Boston to Paris, I Stand Up for Science ✊🇺🇸🇫🇷👩‍🔬@standupforscifr.bsky.social @standupforscience.bsky.social #standupforscience #standupforsciencefrance #standupforscienceParis #Boston

Registration is open for our summer FASEB #Ferroptosis Conference July 27 - 31, 2025. We have a terrific line up of speakers and it's going to be amazzzing! Come join us for this historic first meeting! Please help us to spread the word. 🤩 shorturl.at/QA6T1

Did you know that cancer metabolism works both ways?! Tumors influence the host systemically, while the host's metabolic state also shapes cancer progression... Explore this dynamic interplay in our latest review in @natrevcancer.bsky.social 👇👇👇 www.nature.com/articles/s41...

Metabolic interplays between the tumour and the host shape the tumour macroenvironment - Nature Reviews Cancer

In this Review, Erez and colleagues examine the complex interactions among tumours, their microenvironment and the host, shaping a metabolic macroenvironment that drives cancer progression. They explo...

nature.com

🌟 Excited to share our new Nature Protocols paper! Our method enables detailed lymph collection and multiomic analysis of lymph-derived cancer cells, providing valuable insights into cancer progression. Stay tuned for more discoveries! www.nature.com/articles/s41... #CancerResearch #LymphaticSystem

Lymphatic collection and cell isolation from mouse models for multiomic profiling - Nature Protocols

An approach to collect lymph drained from the primary tumor in mice enables the downstream characterization of the samples using metabolomics, lipidomics and flow cytometry.

nature.com

Our Department of Molecular Metabolism at the Harvard T.H. Chan School of Public Health is hiring for an Asst. Prof. position, help spread the word to help us find a good match! academicpositions.harvard.edu/postings/14371