Phil W
@pwilmarth.bsky.social
Old person forgetting everything they ever knew about proteomics at speeds in excess of 270 Hz...
There's a new series from DC Studios called "Manterns". It's about males who, after 10 years of pumping iron in the gym and taking steroids, find the Exit sign and begin their journey of withdrawal from peptides and mirrors while trying to learn to become men who can talk to independent women...
God, why does NBC bring the B team announcers off of the bench for the end of the Women's Tour? The spectators will get to suffer as much as the racers this weekend!
Norway? No way! What a stage in today's Tour de France. The women riders get less than 1/10th what the men get and provide twice the entertainment.
The first two stages of the Women's Tour de France have been incredibly exciting and fun to watch. Lorena Wiebes is such an amazing sprinter.
Why was it called The Tour de France 2026 instead of Mads dashes to the lines?
What is everyone using for only albumin depletion with #proteomics nowadays? We had been using an Agilent spin column but it has been discontinued.
No science fiction could have prepared us for just how stupid the end of the world can be. "The environment was on the brink of collapse, and so, rather than deal with that, we burned what fuel we had left getting computers to scam each other for money."
The question all males in leadership roles need to constantly be asking, "Does my awful behavior towards women make my penis look really SMALL?".
In #proteomics, better instrumentation usually lets you "discover" that the instrument was not the limitation. That's what discovery proteomics used to be. What masquerades as proteomics these days is dramatically increased cost and complexity resulting in loss of transparency and reproducibility.
Hey all. If you going down to the Mall to wave your freak flag in support of <insert something here>, the flag should be 100% white. MAHA recommended hydration is peptide supplements and *light* beer. Guns are okay but leave the shirt at home. Heavy weight socks with cowboy boots say FU heat dome.
If I put Peptide data in my Supplementary files, can I get MAHA to fund my research???
At tonight's Ultimate Fascist Club bash at the Spite House, enjoy 80-year old men in pissing contests, see nerdy tech bros try to hurt each other with mean words, and, in the main event, watch Stephen Miller and the ICE dancers brutally separate babies and toddlers from their asylum-seeking parents!
Another heavy lift from the titins of proteomics podcasting!
Ben Neely@benneely.com · 2mo agoFor this week’s #THEProteomicsShow, me and Ben @proteomicsnews.bsky.social had the great pleasure of having Keith Baar @musclescience.bsky.social on to chat muscles and tendons. I know I keep saying it, but this was my fav. Find it wherever you find fine podcasts or here anchor.fm/theproteomic...
Ha-ha. Watching the Apple WWD keynote and they are talking about parental controls and how parents are in control. That is as delusional as saying that I am in control of my cats.
Out now, a lovely tour de force led by Brooke Genovese @brookegenovese.bsky.social. The comp and statistical tools Brooke developed for non-model proteomics work are legit and worth a look. (her periodic calls to discuss methods were a bright spot on my cal) www.nature.com/articles/s41...
Serum proteome of the Egyptian rousette bat (Rousettus aegyptiacus) reveals signatures of immunity, proteostasis, and metabolism - Scientific Reports
Bats are increasingly studied for their ability to coexist with diverse viruses of human health importance. While this focus has yielded insights into host–pathogen dynamics, baseline physiological da...
nature.com
Time to call it like it is and refer to Google as Gobble and its search engine as Gobbledygook...
Preemptive joke apology. If you use nanopore sequencing to study urine proteins, would that be piss poor proteomics? #proteomics
Protein corona proteomics is today's version of SELDI (or maybe the next big thing like aptamers). Snake oil proteomics is still going strong. Now with AI!
"Based on the dataset you shared, US and UK responses differ mainly in tone, intensity, and wording style, even though they express similar emotional states" New post on what happened when I got Copilot to do some data analysis: kucharski.substack.com/p/real-signa...
Real signals or artificial stereotypes?
Adventures with a cultural Copilot
kucharski.substack.com
#Proteomics desperately needs a meeting without any vendor presence. No product seminars, no new instruments, no new methods. No fucking AI. No new tech shit at all. Call it "Back to Biology" and try to remember how to do science. Get off of the hamster wheel, for God's sake.
If you have missing values in DIA, something is below the quant level. End of story. If your answer to shit is to add more shit, you have a real shit problem. Can we get back to doing #proteomics and learning how to do actual analytical work? It is about physical concepts not computational magic.
Every friggin' day in America is a new low with no end in sight.
I don't understand why "A" and "I" are being used as an abbreviation for "bullshit" and/or "piece of shit" when BS and POS were so well established. I guess that is the disruptive part of this new frat-boy-mansplaining investor-defrauding rent-seeking surveillance scam tech.
Does it work properly? No. Are the people making it acting in good faith? No. Have they ensured it can't be used maliciously? No. Does it make people's lives better? No. Will it make people's lives better? No. Is it profitable? No. Is it popular? No. Is it harmless? No. The argument for AI.
Unlocking the silent proteome?? Are silent proteins the products of silenced genes? Maybe they are just real quiet and you can't hear them over the rough pump noise? Are they withdrawn because of early translation trauma? Are they non-interacting? Who locked them up? So many questions for AI...
If you find the news headlines don't make any sense, add the two words "for Billionaires" to the end of any headline. Even if you still can't figure it out, at least it will be true.
