Ronald Beavis ❌
@ronbeavis.bsky.social
Retired proteomics wizard & consultant of last resort.
www.thebeaverton.com/2026/08/carn...
Carney vows to fast-track West Coast Pipeline before entire West Coast burns to the ground
OTTAWA - Mark Carney has officially given notice that his government will be designating Danielle Smith’s West Coast pipeline a project of national interest, allowing the massive oil and gas project t...
thebeaverton.com
I don't know who needs to hear this, but if you want keywords from proteins that recently got pruned from UniProtKB, you can use Unisave. I wrote this post which has an associated github repo to help. OR just switch over to 2026_02 ASAP. They told us it was coming. neely.github.io/recovering-u...
Recovering UniProt Keywords for deleted accessions
If you searched against a pre-June 2026 UniProt database, some of your identified proteins no longer exist in the current release — and that means no keywords.
neely.github.io
I think your resource is great, but the G in GPM should stand for glyco, and the whole thing should be revised to only report on glycoproteins. Hope it’s helpful! 🙃
The grim truth about running a publicly available informatics resource is that user feedback in rarely helpful. Most of it is a very thinly veiled attempt to get you to do work for the correspondent on their boutique project so that they don't have to do it themselves.
Canadians overwhelmingly demand wealth tax after Kevin O’Leary says it will make him move away
Canadians overwhelmingly demand wealth tax after Kevin O’Leary says it will make him move away
OTTAWA - Pollsters report a split among Canadians over the idea of higher tax on the assets of wealthy individuals, though support skyrockets after noting that Kevin O'Leary has vowed that he will res...
thebeaverton.com
This is a great story. I expect there's a lot of this going on, around the world. It reads almost as the tech version of an Onion headline, doesn't it? Exactly what @doctorow.pluralistic.net means when he rants about "process knowledge" walking out the door.
Techie lured out of retirement to support software only he remembered
The first job was lucrative and went well, but a pension was preferable to rolling projects
theregister.com
Typhoon Dolphin seems to be taking aim at the Chinese coast.
The fact that AI chat interfaces kiss ass like a Trump crony is probably a significant feature in their popularity with certain people.
By Cory Doctorow (GPG 0xBF3D9110957E5F4C)@doctorow.pluralistic.net · 5d agoCortex *is* the underling, except that unlike a human underling, Cortex *never* back-sasses you about your foolish questions. 65/
"Little Bosses Everywhere" by Bridget Read is a great introduction to the how's and why's that have lead to the reaction of businesses & stock markets to LLM-based speculative plays.
#proteomics_101 Why is it difficult/impossible to represent a negation in biomedical research ontologies, e.g., GO or PSI-MOD? For example, why is it challenging to represent the experimental finding that protein X is not a nuclear protein or that X is not a phosphoprotein?
Not saying everyone was bad at their job, but it is obvious that the worst is ruining it for everyone, and that starts with giving the Mayor the boot.
"A US government map of Africa mislabeled every country during a state department presentation at a global conference in Brazil this week, causing a stir among attenders who took screenshots and posted them online."
US government map of Africa mislabels every country at global conference
State department ‘takes full responsibility’ for erroneous, widely shared chart displayed at Aids conference in Brazil
theguardian.com
A rash of similar sounding, totally made up "incidents" used to generate native ads that could be mistaken for news stories. www.cnn.com/2026/07/30/t...
Anthropic said its AI models hacked into other companies’ systems during testing | CNN Business
AI company Anthropic says that during routine testing some of its models accessed the internet and hacked into three separate organizations’ systems – and that it didn’t notice the models had done so ...
cnn.com
#proteomics_101 Given that multiple lines of investigation are consistent with yeast AIM19:p being a mitochondrial protein, is this pattern of observable peptides consistent with it being imported into the mitochondrial matrix?
www.thebeaverton.com/2026/07/tech...
Tech CEOs warn Chinese AI could destroy the world faster than American AI can
SILICON VALLEY - American Tech CEOs issued a chilling warning that Chinese AI models have the potential to destroy the world more quickly and more cheaply than their American counterparts.
thebeaverton.com
α-Synuclein N-terminal acetylation tunes both its structural and physicochemical properties to enhance binding to lipid bilayers @ispt-proteinterm.bsky.social pubs.acs.org/bichaw/artic...
N-Terminal Amine Chemistry Influences α-Synuclein Interactions with Lipid Bilayers
Abstract. α-Synuclein (αSyn) is an intrinsically disordered protein whose reversible membrane binding via amphipathic α-helix formation is central to its f
pubs.acs.org
More on NAC and cotranslational Nt-acetylation by NatB. Congratulations to the first authors Natalia and Pawel! rdcu.be/ftSay
Structural basis of cotranslational protein N-terminal acetylation by NatB in human cells
Nature Communications - N-terminal acetylation is one of the most common protein modifications. Here, the authors show how NAC recruits the essential enzyme NatB to translating ribosomes, revealing...
rdcu.be
OK folks – decision made. I’m spending too much time following all things proteomics and need to move on to pastures new – Immunodiagnostics. Pastel’s website will be available until it’s renewal in 5months time. 1/3
What a relief that after all of their hard work & a significant fortune spent that the nicest thing they can say about it is that it is cheap & they have somehow "managed to make the model more resistant to being tricked". www.engadget.com/2222542/anth...
Anthropic says Opus 5 can nearly match its top-performing model for half the price - Engadget
Anthropic's latest model offers top-tier performance at a much cheaper cost.
engadget.com
#proteomics_101 What are the key physical properties of human insulin (INS:p) that make it difficult to observe using MS/MS-based proteomics experimental methods? How would you go about improving the likelihood of observing it in clinical fluids?
More on the Trump / Kratsios "Golden Age of Science" report, from @theverge.com
The tech-broification of American science has officially begun
Trump’s ‘Golden Age’ of American science starts with dismantling it, while funneling billions into AI.
theverge.com
The trade winds are still blowing sand off Africa all the way to the Caribbean. (surface wind & PM₁₀ particulates)
Typhoon Noul is making landfall just a bit east of Hong Kong.
Whew, the editors of @science.org are getting real.
The Assault On Science Funding Continues
science.org
#proteomics_101 Yeast VAS1:p (valyl-tRNA synthetase) has the N-terminal sequence shown in the attached figure. Predict the mature N-terminii & all N-acetylation sites with a brief explanation of the mechanisms involved.
#proteomics_101 Yeast GCV2:p has the following N-terminal sequence: 1 MLRTRVTALL CRATVRSSTN YVSLARTRSF HSQSILLKTA 40 Predict the mature N-terminal residue & whether or not it is N-acetylated, with as detailed an explanation as necessary.
