Postdoctoral researcher in spatial transcriptomics and immunology

yefis.org

Investigation of the heterogeneity of cancer cells using single cell Ca2+ profiling

rdcu.be

A specific bone marrow cytokine pattern in de novo acute myeloid leukemia

Acute myeloid leukemia (AML) is a heterogeneous group of hematopoietic cancers. Cytokines play an important role in the regulation of normal and patho…

sciencedirect.com

Pulmonary arterial hypertension and cancer: exploring their resemblance as channelopathies

Pulmonary arterial hypertension (PAH) and cancer may appear to be unrelated at first, but there is increasing evidence that they share many characteri…

sciencedirect.com

L'université de Tours s'associe au mouvement international Stand-up for Science

univ-tours.fr

Triacylglycerol mobilization underpins mitochondrial stress recovery - Nature Cell Biology

Baker et al. show that mitochondrial stress recovery requires mobilization of lipid droplet triacylglycerol stores to facilitate cardiolipin biosynthesis and mitochondrial biogenesis.

nature.com

Transcriptional regulation of KCNA2 coding Kv1.2 by EWS::FLI1: involvement in controlling the YAP/Hippo signalling pathway and cell proliferation - Cell Communication and Signaling

Background Ewing sarcoma (ES), the second main pediatric bone sarcoma, is characterised by a chromosomal translocation leading to the formation of fusion proteins like EWS::FLI1. While several studies...

biosignaling.biomedcentral.com

Redirecting glucose flux during in vitro expansion generates epigenetically and metabolically superior T cells for cancer immunotherapy

T cell therapies for cancer currently rely on extensive in vitro expansion in hypermetabolic conditions. Frisch et al. demonstrate that T cells grown in vitro perform extensive aerobic glycolysis. Rer...

cell.com

Université : vivre ou survivre ?

Avec près de 80% des universités en déficit, la France a-t-elle laissé tomber l’université ? Reste-t-il des raisons d’espérer pour l’enseignement supérieur public ?

radiofrance.fr

Cancers les plus fréquents : le rôle du « gras » dans leur prévention et leur évolution

Le gras influence certains cancers fréquents. Le rôle préventif des acides gras oméga-3 est bien documenté. Mais l'impact de la graisse en excès dans les situations d'obésité reste mal compris.

theconversation.com

Selective deficiency of mitochondrial respiratory complex I subunits Ndufs4/6 causes tumor immunogenicity - Nature Cancer

Puigserver and colleagues show that genetic targeting of specific mitochondrial respiratory complex I subunits in melanoma and breast cancer cells boosts tumor immune surveillance via upregulation of ...

nature.com

Immune evasion through mitochondrial transfer in the tumour microenvironment

Nature - Mitochondria with mutations in their DNA from cancer cells can be transferred to T cells in the tumour microenvironment, which leads to T cell dysfunction and impaired...

rdcu.be

Niche, Nutrition, Cancer & métabolisme Oxidatif (N2COX) | LE STUDIUM

Notre projet de recherche est celui d’une monoéquipe multidisciplinaire centré sur les lipides agissant dans/sur les niches tumorales, plus particulièrement sur le métabolisme énergétique/oxydatif et ...

lestudium-ias.com

Chimeric protein EWS::FLI1 drives cell proliferation in Ewing Sarcoma via aberrant expression of KCNN1/SK1 and dysregulation of calcium signaling - Oncogene

Oncogene - Chimeric protein EWS::FLI1 drives cell proliferation in Ewing Sarcoma via aberrant expression of KCNN1/SK1 and dysregulation of calcium signaling

nature.com

Glycolytic activity following anti‐CD19 CAR‐T cell infusion in non‐Hodgkin lymphoma

Energy metabolism of chimeric antigen receptor-T cells (CAR-T) activation in humans remains unexplored. As a glycolytic activity surrogate, we investigated the dynamics of peripheral blood (PB) lacta...

onlinelibrary.wiley.com

Sardines, maquereaux et autres poissons gras : contre le cancer, l’intérêt des oméga-3 et lipides du milieu marin

Les lipides issus du milieu marin se révèlent prometteurs contre les cancers. Soit en prévention à l’image des oméga-3 présents dans certains aliments (sardines, maquereaux…). Soit pour développer des...

theconversation.com

Ion channel signaling in health and disease | LE STUDIUM

Mohamed Trebak, Marie Potier-Cartereau & Chistophe Vandier

lestudium-ias.com

Synthesis and biological evaluation of new tri-heterocyclic derivatives as anti-colorectal cancer agents

Colorectal cancer is a major health problem, with a poor prognosis if not detected at early stage. It is the third most common cancer worldwide and th…

sciencedirect.com