Have you submitted your abstract?

International Society for Transgenic Technologies (ISTT)@transtechsociety.org · 4mo ago

📅 2 weeks to go! There’s still time to take advantage of the Early Bird registration rate for TT2026 in Leiden. ✔ Be part of an exciting scientific programme 🎟 Early Bird deadline: 15 April 2026 #TT2026 #EarlyBird #AcademicConference #leiden2026 tt2026.org/registration/

We plan to facilitate replacement training at our Advance training centre and lead the @mrcmousenetwork.bsky.social Best Models Working Group, which provides a forum for researchers to learn about alternative models and connect with experts in other systems www.har.mrc.ac.uk/services/rep...

Replacement of Animals in Medical Research | Mary Lyon Centre

Animals are currently used where there is no scientifically satisfactory alternative, but there has been considerable progress in developing new methodologies that could replace the use of animals in ...

har.mrc.ac.uk

We welcome the government’s effort to provide a clear roadmap for the phasing out of the use of animals in research, while maintaining scientific rigour and safety standards.

NC3Rs@nc3rs.bsky.social · 9mo ago

Today the UK government has released a strategy to support the development, validation and uptake of alternative methods. Read more: www.gov.uk/government/n...

Please visit lag-r.org/guidelines/ for handy forms to document the genetics of laboratory animals in publications.

LAG-R - Laboratory Animal Genetic Reporting

The LAG-R framework (Laboratory Animal Genetic Reporting) is a set of guidelines to support more complete documentation of the genetic make-up of animals of all species that are used in research, with...

lag-r.org

Mouse Genome Informatics@mousegenome.bsky.social · 2y ago

The LAG-R framework (Laboratory Animal Genetic Reporting) has been published in Nature Communications (doi.org/10.1038/s414...). The LAG-R framework supports documentation of the genetic make-up of research animals, bolstering reproducibility.

Characterisation and documentation of experimental models - in vitro and in vivo - for research #reproducibility.

PLOS Biology@plosbiology.org · 9mo ago

Incomplete characterization and inconsistent reporting of laboratory animal #genetics undermine study quality and limit research #reproducibility. @reproducibilityexp.bsky.social highlight the LAG-R guidelines and call for collective action to enhance scientific integrity.🧪

If you want advice on selecting the most appropriate model for your research, contact the NMGN Best Models Working Group to be connected with researchers with expertise in diverse biological models and computational tools: nmgn.mrc.ukri.org/working-grou... #MeetTheExpert #3Rs

Meet the Experts | National Mouse Genetics Network

We connect researchers with specialists in diverse model systems to support innovation and refinement.

nmgn.mrc.ukri.org

Characterisation and documentation of experimental models - in vitro and in vivo - for research #reproducibility.

PLOS Biology@plosbiology.org · 9mo ago

Incomplete characterization and inconsistent reporting of laboratory animal #genetics undermine study quality and limit research #reproducibility. @reproducibilityexp.bsky.social highlight the LAG-R guidelines and call for collective action to enhance scientific integrity.🧪

@lydiateboul.bsky.social and Michelle Stewart lend their decades long experience to highlight the need for rigorous documentation in in vivo studies #MouseGenetics #documentation #ScientificRigour

Mary Lyon Centre at MRC Harwell@mrcharwell.bsky.social · last yr.

Parent-of-origin of alleles: an essential variable in in vivo experiments: A new paper from Lydia Teboul and Michelle Stewart highlights the essential role of systematic documentation of genetics and breeding patterns for ensuring reproducibility. www.nature.com/articles/s41...

Please visit lag-r.org/guidelines/ for handy forms to document the genetics of laboratory animals in publications.

LAG-R - Laboratory Animal Genetic Reporting

The LAG-R framework (Laboratory Animal Genetic Reporting) is a set of guidelines to support more complete documentation of the genetic make-up of animals of all species that are used in research, with...

lag-r.org

Mouse Genome Informatics@mousegenome.bsky.social · 2y ago

The LAG-R framework (Laboratory Animal Genetic Reporting) has been published in Nature Communications (doi.org/10.1038/s414...). The LAG-R framework supports documentation of the genetic make-up of research animals, bolstering reproducibility.

There's still time to complete the straightforward application form for our current Genome Editing Mice for Medicine call before the extended deadline on 31st January to be in with a chance of getting your free, novel, genetically altered mouse model generated

GEMM | Mary Lyon Centre

Submit an application to have your free, novel, genetically altered mouse model generated by the Mary Lyon Centre

har.mrc.ac.uk

Researchers at Newcastle University have used a conditional mouse mutant made by the MLC's Genome Editing Mice for Medicine (GEMM) programme to investigate a poison exon in the splicing regulator Tra2b that is essential for male fertility: www.har.mrc.ac.uk/news/a-gemm-...

A GEMM programme mouse model used to investigate a poison exon essential for male fertility | Mary Lyon Centre

Researchers at Newcastle University are using a conditional mouse mutant made by the Mary Lyon Centre’s Genome Editing Mice for Medicine (GEMM) programme to study the role of an ultra-conserved exon in the splicing regulator gene Tra2b. Many genes function as instructions for producing proteins, which perform the majority of tasks within our cells. To […]

har.mrc.ac.uk

Part of the reason for mosaicism in genome editing?

Wellcome Sanger Institute@sangerinstitute.bsky.social · 2y ago

Read ‘Prolonged persistence of mutagenic DNA lesions in somatic cells’ from @mikespencerchapman.bsky.social @sangerinstitute.bsky.social @qmbci.bsky.social & others in @nature.com, here ⤵️ www.nature.com/articles/s41...