David Christensen from the Mary Lyon Centre at MRC Harwell @mrcharwell.bsky.social is joining #BOARD26 to promote understanding of how animal research and other approaches complement each other. #BOARD #EARA #SCICOMM
@dbogani.bsky.social
As the political climate around animal research becomes less supportive in the UK, it is our interest to argue for & protect organismal biology. BBSRC opened a survey, which gives us a timely platform. Please fill & share link among colleagues. Deadline: 9/2 engagementhub.ukri.org/mrc-bbsrc/la...
An elegant approach using a mix of technologies and making the most of resources generated over many years of research into the canonical Wnt pathway. And results which have the potential to andvance personalised treatment for some forms of cancer. Congrats @andrewwood.bsky.social and collaborators!
MRC National Mouse Genetics Network@mrcmousenetwork.bsky.social · 6mo agoFresh insights reveal how cancer gene mutations drive tumour growth: Andrew Wood (lead of our Degron Cluster) has co-led a team that created a comprehensive map that shows how hundreds of possible mutations in a key cancer gene influence tumour growth nmgn.mrc.ukri.org/news/fresh-i...
Our Best Models Working Group can offer advice on the use of a range of model systems. The next in our series highlighting our diverse expertise features Dr Andrew Wood, whose lab uses genome editing and targeted protein degradation to study genetic disease using cell lines, organoids, and mice.
Our Best Models Working Group can offer advice on the use of a range of model systems. The next in our series of posts highlighting our diverse expertise features Dr Alex Whitworth, whose group uses Drosophila models of neurodegenerative diseases. nmgn.mrc.ukri.org/working-grou...
📢 Job Alert 📢 Post-doc position at #LancasterUniversity working on the #MURIDAE project @mrcmousenetwork.bsky.social Working with #genetic #preclinical models for #schizophrenia 🧠🧬🐭 Please repost! www.jobs.ac.uk/job/DPW471/s...
Senior Research Associate at Lancaster University
An opportunity for an academic position as a Senior Research Associate is available, as advertised on jobs.ac.uk. Apply now and explore other academic job openings.
jobs.ac.uk
Exciting times ahead!
Mary Lyon Centre at MRC Harwell@mrcharwell.bsky.social · 8mo agoThe @mrc-tu.bsky.social and Dept of Biochemistry, @cam.ac.uk, @astra-zeneca.bsky.social, @cruk-si.bsky.social, and the MLC have been awarded a £3.4 million MRC Prosperity Partnership grant to fund research into understanding the toxicity of advanced therapeutics: www.har.mrc.ac.uk/news/new-aca...
We welcome the government’s effort to provide a clear roadmap for the phasing out of the use of animals in research, while maintaining scientific rigour and safety standards.
NC3Rs@nc3rs.bsky.social · 9mo agoToday the UK government has released a strategy to support the development, validation and uptake of alternative methods. Read more: www.gov.uk/government/n...
We plan to facilitate replacement training at our Advance training centre and lead the @mrcmousenetwork.bsky.social Best Models Working Group, which provides a forum for researchers to learn about alternative models and connect with experts in other systems www.har.mrc.ac.uk/services/rep...
Replacement of Animals in Medical Research | Mary Lyon Centre
Animals are currently used where there is no scientifically satisfactory alternative, but there has been considerable progress in developing new methodologies that could replace the use of animals in ...
har.mrc.ac.uk
Our guys offering their expertise 😊🙌🏻
Mary Lyon Centre at MRC Harwell@mrcharwell.bsky.social · last yr.Sharing what we know again! Decades of experience distilled into a workshop at #FELASA2025 in which, our senior team talk about how to reduce severity of animal procedures right from the start of a project using GA mice, and limiting welfare issues. #3Rs #AnimalWelfare #training
Top quality teamwork by @cost-teatime.bsky.social repositories WG to address a key issue in maximising the impact of #Home-cageMonitoring. From the first working group meeting @mrcharwell.bsky.social in Oct’24 to V1 of the preprint in May’25!! Take a sneak peak 👀 here: osf.io/preprints/os...
Another one from the MRC National Mouse Genetics Network #organoids #conference #netweorking
MRC National Mouse Genetics Network@mrcmousenetwork.bsky.social · last yr.We are co-organising another international conference: Organoids Are Us is a symposium to report and discuss the latest advances in this exciting modality to tackle unanswered biological and clinical questions. For more info nmgn.mrc.ukri.org/news/we-are-...
Last month was a busy one for the Network's scientists. Some of our MURIDAE cluster members and associates attended the @britishneuro.bsky.social (BNA) #BNA2025 and organised a symposium. Read our short report on the work they showcased! nmgn.mrc.ukri.org/news/bna-fes... @mrcharwell.bsky.social
BNA Festival of Neuroscience - We were there! | National Mouse Genetics Network
The British Neuroscience Association (BNA) Festival of Neuroscience 2025 was held in Liverpool from the 27th to the 30th of April. The Festival certainly started with a bang, as Liverpool […]
nmgn.mrc.ukri.org
Check out this post from @dbogani.bsky.social @mrcharwell.bsky.social about a new tool to assist scientists, policy makers, funders and reviewers in eliminating persistent sex bias in biomedical research: thenode.biologists.com/new-framewor...
New Framework Aims to Eliminate Sex Bias in Preclinical Research - the Node
An important new resource for researchers, reviewers, and funders has been developed with major contributions from the Mary Lyon Centre at MRC Harwell. A
thenode.biologists.com
Sponsoring #Pint25 at a packed @oxfordblue.bsky.social and our own @rsbains.bsky.social going through the journey to passive behaviour monitoring powered by #AI @mrcharwell.bsky.social
Beautiful morning here in Liverpool! If you are attending #BNA2025 @britishneuro.bsky.social check out our symposium this afternoon, Room 3A S21: The MRC National Mouse Genetics Network: Translating genetic findings using preclinical mouse models @mrcmousenetwork.bsky.social
Check out also our post to see how the @mrcharwell.bsky.social contributed to the work and what we think it will me for #preclinical in vivo studies and better #TranslationalResearch outcomes www.har.mrc.ac.uk/news/new-fra...
New Framework Aims to Eliminate Sex Bias in Preclinical Research
An important new resource for researchers, reviewers, and funders has been developed with major contributions from the Mary Lyon Centre. A group of researchers and policy leaders from organisations in...
har.mrc.ac.uk
NC3Rs@nc3rs.bsky.social · last yr.Using female and male animals in in vivo studies is important to produce reproducible, generalisable and meaningful results using the fewest number of animals. The Sex Inclusive Research Framework (SIRF) helps you check if sex has been fully considered in study design: nc3rs.org.uk/news/sex-inc...
Very full schedule at our #IMGCglasgow workshop last week, delivered by MitoCluster team @robpitceathly.bsky.social, Carlo Viscomi, @mitogene.bsky.social, and @jim-ca.bsky.social. A pleasure to attend, thanks for the invite @mrcmousenetwork.bsky.social & IMGS! 🧬 #mitochondria #MouseModels #ECR
Not a network talk but we really enjoyed this one by @davidashbrook.bsky.social on transgenic models of Alzheimer’s Disease on different genetic backgrounds. Loads of data and incredible imaging!
What a welcome by #Glasgow City Chambers! One of the highlights of this #IMGCGlasgow! @yannherault.bsky.social
This morning session is Network loaded, starting with Sevda Boyanova from the @ukdri.ac.uk talking about the standardised phenotyping pipelines established for Alzheimer’s and frontotemporal dementia mouse models at the @mrcharwell.bsky.social Great attendance despite the early start! #IMGCGlasgow
Our Director Owen Sansom describing decades long work that is now involving the Cancer Cluster to generate and characterise mouse models of colorectal cancer that more faithfully recapitulate human disease #IMGCGlasgow
And finally Claus Nerlow form the Haem Cluster describing models of acute leukaemia regulated by GATA2 mutations #IMGCGlasgow
Ageing Cluster member Nicholas Schaum presenting the cluster and the work he’s doing to advance our understanding of the ageing process and the possible intervention points for a healthier life using #mouse cohorts at different age points #IMGCGlasgow #AgeingResearch @mrcharwell.bsky.social
Kicking off the main sessions today with a welcome from IMGS president Yan Herault and Network Director Owen Sansom #IMGCGlasgow
Waiting for the delegates to come and start the science rolling. Trainee workshops and symposium today! #IMGCGlasgow
@lydiateboul.bsky.social and Michelle Stewart lend their decades long experience to highlight the need for rigorous documentation in in vivo studies #MouseGenetics #documentation #ScientificRigour
Mary Lyon Centre at MRC Harwell@mrcharwell.bsky.social · last yr.Parent-of-origin of alleles: an essential variable in in vivo experiments: A new paper from Lydia Teboul and Michelle Stewart highlights the essential role of systematic documentation of genetics and breeding patterns for ensuring reproducibility. www.nature.com/articles/s41...
Today we are delighted to host RYUSEI MAEDA from our long standing friend and collaborator Toru Takeo’s lab in Japan. It’s great to find out about his work and interest in science communication as he spends a bit of time in our labs. And it’sa full lecture room! #collaboration #ReproductiveBiology
