Summer @labsoap.bsky.social papers : all about cell deaths 1. LUBAC and pyroptosis @cp-iscience.bsky.social www.cell.com/iscience/ful... 2. CYLD and mitochondrial death @emboreports.org link.springer.com/article/10.1... 3. CK1a and cGAS/STING #CellDeathDiff www.nature.com/articles/s41...
Yanis Macé, Nicolas Bidère and co-workers show that CYLD is a target of #caspase -3. CASP3-induced cleavage of CYLD tempers inflammatory signaling and heps maintain #apoptosis silence. #inflammation #CellDeath #ubiquitin -> link.springer.com/article/10.1...
This week #JournalClub #ferroptosis #iron #lysosome @nature.com @institutcurie.bsky.social www.nature.com/articles/s41...
Activation of lysosomal iron triggers ferroptosis in cancer - Nature
Some cancer cells exhibit high loads of reactive iron in lysosomes, and this feature is exploited by using fentomycin-1, a newly developed small molecule, to induce ferroptosis.
nature.com
👏 Congratulations #YanisMace @nbidere.bsky.social @tiphainedouanne.bsky.social @insermgrandouest.bsky.social 🔍 CYLD cell death and more
@tiphainedouanne.bsky.social · 2y agoHappy to share our mini-review on CYLD, its role at the crossroads of life and death decisions, and its regulation through PTMs. @nbidere.bsky.social #YanisMace @labsoap.bsky.social @insermgrandouest.bsky.social www.frontiersin.org/journals/cel...
Important Fact: Higher Education and Research is the place where LGBTI+phobic assaults are most common. What can we do? - Continue to stay informed and educated - Include and make LGBTI+ people visible - Reject harmful behaviors Here is our SOAPainbow 🌈
This #JournalClub @labsoap.bsky.social #Lysosomes #CellDeath #Degradation @science.org @robzonculab.bsky.social www.science.org/doi/10.1126/....
Leucine aminopeptidase LyLAP enables lysosomal degradation of membrane proteins
Breakdown of every transmembrane protein trafficked to lysosomes requires proteolysis of their hydrophobic helical transmembrane domains. Combining lysosomal proteomics with functional genomic dataset...
science.org
This week @labsoap.bsky.social #JournalClub #bleb #extracellularvesicle @naturecellbiology.bsky.social www.nature.com/articles/s41...
Blebbisomes are large, organelle-rich extracellular vesicles with cell-like properties - Nature Cell Biology
Jeppesen, Sanchez et al. identify blebbisomes as large membrane-enclosed vesicles containing organelles and secreted by cells. Blebbisomes can both secrete and internalize exosomes and microvesicles.
nature.com
merci @ouest-france.fr pour la mise à lumière des travaux #recherche #cancer #cerveau #liguecontrelecancer @insermgrandouest.bsky.social @cnrsbiologie.bsky.social @sdcnantes.bsky.social www.ouest-france.fr/sante/cancer...
Cancer du cerveau : « On avance », dit la chercheuse nantaise
À l’occasion de la semaine du cerveau, focus sur Julie Gavard, qui encadre une équipe de chercheurs et de thésards qui planchent sur les tumeurs malignes du cerveau de l’adulte.
ouest-france.fr
👀 📝 Words of Advice #co-development #postdocs @febspress.bsky.social @tiphainedouanne.bsky.social @laisbfugio.bsky.social #JaneJardine #QuentinRoux @sararosinska.bsky.social in @labsoap.bsky.social @nbidere.bsky.social @insermgrandouest.bsky.social febs.onlinelibrary.wiley.com/doi/10.1111/...
FEBS Press
‘Who in their right mind would add another meeting to an already overflowing schedule?’ This thought crossed our minds when we first discussed the idea of a postdoc peer group meeting. We are five ea....
febs.onlinelibrary.wiley.com
Our #2025 SOAPbox @labsoap.bsky.social getting ready to celebrate our 10th year anniversary in #nantes 🎁🎂🎊
L’Inserm est solidaire du mouvement Stand Up For Science presse.inserm.fr/cest-dans-la... #StandUpForScience2025
À l’occasion de la Journée internationale des femmes et filles de science, testez vos connaissances sur les femmes scientifiques et l’égalité dans la recherche. 👉 mpdf.cnrs.fr/le-quiz-femm... #FemmesEnScience #WomenInScience
This week #JournalClub @labsoap.bsky.social on #microplastic #bloodbrainbarrier #plastifou in @science.org www.science.org/doi/10.1126/... 🧠🏭🍃
Microplastics in the bloodstream can induce cerebral thrombosis by causing cell obstruction and lead to neurobehavioral abnormalities
Microplastics get in the blood and are eaten by immune cells, leading to cell obstruction and cerebral thrombosis.
science.org
Thanks to #OTablo initiative #NantesUniversité we could draw @labsoap.bsky.social team recent work on #centriolarsatellites 🖼️🎨🖌️🧑🔬🔬 and its beautiful ! Kudos to all involved 🤗
please check our recent publication on #EV #extracellularvesicle #breastcancer #lipids @insermgrandouest.bsky.social #JExtracellBio isevjournals.onlinelibrary.wiley.com/doi/10.1002/... thanks to all involved including our funding agencies
Monitoring concentration and lipid signature of plasma extracellular vesicles from HR+ metastatic breast cancer patients under CDK4/6 inhibitors treatment
Extracellular vesicles (EVs) are cell-derived small membrane structures that transport various molecules. They have emerged as potential circulating biomarkers for monitoring responses to cancer ther...
isevjournals.onlinelibrary.wiley.com
@labsoap.bsky.social is proud to announce the 8th SOAPosium on the 12th of December, one more year of SOAP to enjoy together with our guest #VincentSauzeau #InstitutduThorax @insermgrandouest.bsky.social All we want is teamwork (and chocolate) 🎵
The RBR E3 ubiquitin ligase HOIL-1 can ubiquitinate diverse non-proteinaceous substrates in vitro https://www.biorxiv.org/content/10.1101/2024.11.29.626046v1
The RBR E3 ubiquitin ligase HOIL-1 can ubiquitinate diverse non-proteinaceous substrates in vitro https://www.biorxiv.org/content/10.1101/2024.11.29.626046v1
HOIL-1 is a RING-between-RING (RBR)-family E3 ubiquitin ligase and component of the linear ubiquitin
biorxiv.org
This week #JournalClub @labsoap.bsky.social #Cancer_Cell #P53 #STING #BH3mimetics www.cell.com/cancer-cell/...
Putting the STING back into BH3-mimetic drugs for TP53-mutant blood cancers
Diepstraten et al. demonstrate that p53 enforces apoptosis induced by BH3-mimetic drugs. To boost BH3-mimetic-induced apoptosis in TP53-mutant blood cancers, STING agonists were employed to induce pro...
cell.com
