What happens to a macrophage that is infected for a long time? Senescence! Once we clear those senescent cells with senolytics, the bacterial burden drops. This is a new way to tackle infections without using antibiotics. Link in comment! #ICSAPaperOfTheMonth @edoardoscarpanti.bsky.social

In the #ICSAPaperOfTheMonth, the Passos and @adamsbioaging.bsky.social lab reveal how mitochondrial metabolism controls the SASP through epigenetic regulation. Targeting mitochondrial citrate transport reduces inflammation and improves healthspan in aged mice. Link 👉 www.nature.com/articles/s41...

🏆 #ICSAPaperOfTheMonth Telomere shortening has long been considered a cause of cellular senescence. Fabrizio d'Adda and team now show telomeric DNA damage signalling is itself a causal driver of hematopoietic decline. www.nature.com/articles/s43... @nataging.nature.com

Senescence isn't just aging, it can be fast and functional. New work from Valdivieso & Rozmarič @lbitrauma.bsky.social shows "aged" cells coordinate wound healing within hours of injury, challenging the classic view. Interview with the authors: www.cellsenescence.info/post/copy-of...

PotM - June 2026

Transcription-independent induction of rapid-onset senescence is integral to healingValdivieso, K., Rozmaric, T., et al., Nature Cell Biology 2026Brief Summary:The study by Karla Valdivieso and Tomaž ...

cellsenescence.info

Join Amina Abdul-Aziz for the next @yicsac.bsky.social Webinar! From leukemia research to senescence biology 🧬 📅 Apr 17 | ⏰ 16:00 CEST 💻 Online 👉 Register us06web.zoom.us/meeting/regi... #yICSAWebinarSeries #senescence

The ICSA paper of the month is by @amor-lab.bsky.social & beyazlab ‼️ Anti-uPAR CAR T cells reverse and prevent aging-associated defects in intestinal regeneration and fitness. #ICSAPaperOfTheMonth @cshlnews.bsky.social 🔗 www.nature.com/articles/s43...

🎙️ We’re excited to start 2026 with our first @yicsac.bsky.social webinar featuring @oelsallabi.bsky.social , Postdoctoral Researcher at the University “G. d’Annunzio” 🇮🇹 🧬 Cellular senescence, ovarian aging & senotherapeutics 👉 Register: us06web.zoom.us/meeting/regi... #yICSAWebinarSeries #Senescence

🎙️ We’re thrilled to host @icsasenescence.bsky.social President Marco Demaria (ERIBA) for his seminar "From Cells to Systems: My Journey Through Senescence and Science." 📅 Join us online on 9 Dec at 16:00 CET! 🔗 Register here: us06web.zoom.us/meeting/regi...

The General Assembly closed #ICSA2025Rome with big announcements 🎉 ✨ New ICSA President, VP & Steering Committee ✨ yICSA updates for the year ahead ✨ Poster Prize winners celebrated 🏆

Exciting news from the General Assembly at #ICSA2025Rome: the next ICSA meeting will take place in Seoul, South Korea in 2026! Looking forward to seeing this community come together again.

Day 3 began with Session 7 at #ICSA2025Rome: exploring senescence pathways from mechanisms to therapeutic opportunities. A strong finish to the scientific program!

Closing Day 2 of #ICSA2025Rome with the Gala Dinner & Party 🎉

Session 6 at #ICSA2025Rome linked senescence to aging pathologies — from telomere biology to organ function, frailty, and cancer.

A memory from Session 5 at #ICSA2025Rome: senescence and cancer at the crossroads of biology and therapy which also featured dynamic Flash Talks.

Remembering Session 4 at #ICSA2025Rome: a deep dive into the cellular mechanisms of senescence — spanning metabolism, mitochondria, and immunity. A fascinating way to start Day 2!

It was great to be at #ICSA2025Rome grateful to present my research & connect with brilliant scientists. Thanks to MarcoDeMaria, @martakova.bsky.social & Fabrizio D’Adda di Fagagna for the outstanding organization! @icsasenescence.bsky.social @yicsac.bsky.social

Incredible conference the #icsarome2025!! Amamzing since and even better people, so lucky to have joined this community @icsasenescence.bsky.social.

@icsasenescence.bsky.social #icsarome2025. What a great meeting!! Thank you again for the organization, all the presentations and discussions!

Highlights from yICSA at #ICSA2025Rome 🌍✨ ✔️Networking Social Event 🤝 ✔️Special Session with career insights from @dimiccolab.bsky.social & @narita-lab.bsky.social 🙌 Thank you to everyone who joined us! #yICSA #Senescence #ECR

I had a great time presenting my work on mtDNA replication and senescence from the @wanrooij20.bsky.social lab @umeauniversitet.bsky.social today at the #ICSA2025Rome conference, with super exciting discussions. Thanks a lot @icsasenescence.bsky.social and @yicsac.bsky.social !

We are greatly enjoying the exciting science (and location) at ICSA 2025 Rome #ICSA2025Rome @icsasenescence.bsky.social

Final day @icsasenescence.bsky.social 2005 meeting #icsa2025 Great science exciting sessions outstanding scientists. Thanks to the organizers @marcodemaria.bsky.social @martakova.bsky.social @FdAdF66 and to #UPO #agingproject for the Viral Infections&senescence session @irvinlab.bsky.social

Day 1 of #ICSA2025Rome kicks off! 🌍 Opening remarks by @marcdema.bsky.social & Dot Bennett highlighting ICSA’s history and community. Excited for a full day on senescence!

Excited to dive into fascinating science on cellular senescence! @yicsac.bsky.social @icsasenescence.bsky.social #CellularSenescence #Aging #ICSA2025 #yICSA”

It was great having the chance to present some of the great work done by @victornzq.bsky.social in our lab at @cimususc.bsky.social within the fantastic #ICSA2025rome meeting. Thanks to @icsasenescence.bsky.social and the organizers, especially @martakova.bsky.social

So happy to be at the CNR in Rome hosting the 10th Annual @icsasenescence.bsky.social Meeting and the 2nd #PhaedonInstitute SenoTherapeutics Summit. It's finally time to sit back and enjoy the science 😎🥂 #ICSA2025Rome

I've just submitted my first UKRI fellowship application 🤞🎉meanwhile I've been out and about recently sharing early results of our research @nutritionsociety.bsky.social's SIG in Phytochemicals in Health @bsrageing.bsky.social and prepping for @icsasenescence.bsky.social Looking forward to it! 🔬🧪 🧬👩‍🔬

Registration is open! Join the II International SENESCEL Conference on Cellular Senescence in Health & Disease 🧬 📍 Nov 6–7, 2025 | PRBB, Barcelona 🌍 senescel2025.senescel.org Short talks & poster teasers for #ECRs! @senescel.org @vrodillab.bsky.social

The countdown is on — the @icsasenescence.bsky.social Meeting in Rome is almost here! 🎉 We’re looking forward to seeing you, with plenty of activities and updates to come. Stay tuned!

#ICSAPaperOfTheMonth. sin-lncRNA interacts with the TCA enzyme DLST to maintain metabolic balance during senescence. Depletion of sin-lncRNA causes DLST translocation to the nucleus triggering transcriptional changes that lead to metabolic reprogramming in senescence.