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Diorge Souza

@diorgeps.bsky.social

Structural biochemist and evolutionary microbiologist 🇺🇸 MIT / Brandeis University Formerly 🇬🇧 MRC LMB / University College London 🇧🇷 University of São Paulo / University of Brasília

26 Posts229 Follower360 Folgt
Diorge Souza@diorgeps.bsky.social · 3mo ago

How do bacteria avoid killing their own siblings while using contact-dependent weapons? In this work, a conserved DUF4189 protein (Xac2611/Tpf) blocks X-T4SS mediated killing, likely via interaction with VirB5. Great work led by my friend @okagu.bsky.social at the @chuckfarah.bsky.social lab

Gabriel Oka@okagu.bsky.social · 3mo ago

Happy to share our new bioRxiv preprint: “To Kill or not to Kill: A Conserved Trans-Intoxication Protection Factor Blocks X-T4SS-Mediated Fratricide through Interaction with VirB5” www.biorxiv.org/content/10.6...

Alex Bisson@archaeon-alex.bsky.social · 5mo ago

Another paper on a topic we never worked on before: a new ribosomal hibernation! Under the leadership of the super-postdoc Diorge, Davis Lab (ribo-cryoEM master), and @vikramalva.bsky.social (protein-evo whisperer), we identified AHA (not the song, but archaeal hibernation AMPKγ factor). (1/2)

Diorge Souza@diorgeps.bsky.social · 5mo ago

A new preprint from the @archaeon-alex.bsky.social and Joey Davis (MIT) labs! We solved the structure of the ribosome from the archaeon Haloferax volcanii and discovered a new highly conserved ribosome hibernation factor that we named AHA (AMPKγ–HPF from Archaea) 🧵⬇️ www.biorxiv.org/content/10.6...

Vikram Alva@vikramalva.bsky.social · 5mo ago

Very cool work led by @diorgeps.bsky.social from the labs of @archaeon-alex.bsky.social & Joey Davis (MIT)! They solved the Haloferax volcanii ribosome and characterize AHA, a conserved archaeal hibernation factor. With several recent related preprints, it’s an exciting moment for the field!

Diorge Souza@diorgeps.bsky.social · 5mo ago

A new preprint from the @archaeon-alex.bsky.social and Joey Davis (MIT) labs! We solved the structure of the ribosome from the archaeon Haloferax volcanii and discovered a new highly conserved ribosome hibernation factor that we named AHA (AMPKγ–HPF from Archaea) 🧵⬇️ www.biorxiv.org/content/10.6...

Diorge Souza@diorgeps.bsky.social · 8mo ago

So happy to see this come together! Huge congratulations to my friend @javierespadas.bsky.social and everyone involved. Amazing job!

Javier Espadas@javierespadas.bsky.social · 8mo ago

New preprint from the lab!!🎉 We show that Asgard archaea ESCRT-III proteins can trigger membrane fission and reveal its molecular mechanism, offering clues to how these cells may have built internal compartments. But do these organisms even have these compartments? www.biorxiv.org/content/10.1...

Buzz Baum@buzzbaum.bsky.social · 8mo ago

Javier has done beautiful work (following on from the study he did with Diorge Souza), showing how Asgard Escrt-III likely cut membranes. The answer: with Hofund.

Javier Espadas@javierespadas.bsky.social · 8mo ago

New preprint from the lab!!🎉 We show that Asgard archaea ESCRT-III proteins can trigger membrane fission and reveal its molecular mechanism, offering clues to how these cells may have built internal compartments. But do these organisms even have these compartments? www.biorxiv.org/content/10.1...

Roux Lab, Geneva@rouxlab.bsky.social · 8mo ago

Fantastic work from Javier @javierespadas.bsky.social in collaboration with @buzzbaum.bsky.social and @kaksonen.bsky.social labs, thank you Chris Toret, thank you Diorge @diorgeps.bsky.social!

Javier Espadas@javierespadas.bsky.social · 8mo ago

New preprint from the lab!!🎉 We show that Asgard archaea ESCRT-III proteins can trigger membrane fission and reveal its molecular mechanism, offering clues to how these cells may have built internal compartments. But do these organisms even have these compartments? www.biorxiv.org/content/10.1...

Javier Espadas@javierespadas.bsky.social · 8mo ago

New preprint from the lab!!🎉 We show that Asgard archaea ESCRT-III proteins can trigger membrane fission and reveal its molecular mechanism, offering clues to how these cells may have built internal compartments. But do these organisms even have these compartments? www.biorxiv.org/content/10.1...

Molecular basis for cellular compartmentalization by an ancient membrane fission mechanism

The emergence of cell compartmentalization depends on membrane fission to create the endomembrane compartments. In eukaryotes, membrane fission is commonly executed by ESCRT-III, a protein complex con...

biorxiv.org

Javier Espadas@javierespadas.bsky.social · last yr.

Extremely happy to see our work finally out!🎉 Great collaboration between @rouxlab.bsky.social @buzzbaum.bsky.social labs and a real pleasure to work and share co-first authorship with incredible scientists and friends @diorgeps.bsky.social @sami-c.bsky.social. Big thanks to the rest of the authors!

MRC Laboratory of Molecular Biology@mrclmb.ac.uk · last yr.

New research on ancient Asgard archaeal ESCRT-III proteins reveals evolutionary secrets of membrane remodelling. Diorge Souza, Javier Espadas and Sami Chaaban, investigated the ESCRT-III proteins with Buzz Baum and Aurelien Roux. Read more: www2.mrc-lmb.cam.ac.uk/asgard-archa... #LMBResearch (1/2)

Evolution, structure and membrane remodelling function of the ESCRT-III superfamily in eukaryotes and their closest relatives Asgard archaea. The two subfamilies, B-type and A-type, have distinct structural properties to perform sequential steps of the membrane remodelling pathway.