If I were an Early Career Researcher (#ECR) today, I wouldn’t join a lab that doesn’t #preprint (the PI agreed to keep paying me until my paper is finally published). It now takes ages to get papers through peer review, and without preprints you’re putting your future in someone else’s hands.

Lipids build the membranes of all cells, but identifying their precise functions is extremely challenging. Here’s our attempt to change that: How to find and understand lipid-protein interactions, by Katelyn Cook & company. www.biorxiv.org/content/10.6...

Very happy to see this #MechanoGolgi story out (and in full open access, thanks to @upf.edu). Thanks a lot to everyone who contributed and helped make this possible, and, hopefully, more to come! rupress.org/jcb/article/...

Felix Campelo@felixmendu.bsky.social · 11mo ago

🧵 I've been meaning to write a #Skytorial on our recently posted prepring in which we show evidence that the Golgi 🥞 is a mechanoresponsive organelle. Extracellular mechanical forces also tune Golgi export capacity! 👉 www.biorxiv.org/content/10.1...

Check it out! Lipid membrane asymmetries define the directionality of membrane remodeling by ESCRT-III proteins! Congrats @joshuatran.bsky.social and @rouxlab.bsky.social !!

Joshua Tran@joshuatran.bsky.social · 3w ago

💡New Preprint! How does a cell control which way a membrane bends? ESCRT-III has the remarkable ability to reshape membranes and drive reverse-topology fission, yet a fundamental question has remained: what determines the direction of membrane remodeling? www.biorxiv.org/content/10.6...

This story is now published in @natplants.nature.com ! 🎉🎩 Check out the final article here: nature.com/articles/s41477-026-02361-1 Very similar to the original bioRxiv preprint, with the addition of some cool polysome analysis (in the supplementals)! Thanks and congrats to everyone involved! 🙏

Chloroplast-encoded small subunit extensions reshape the Chlamydomonas chlororibosome - Nature Plants

Using in situ cryo-electron tomography, researchers found a unique ‘arm’ domain on the small subunit of Chlamydomonas chlororibosomes. This discovery suggests that chlororibosome structure is more evo...

nature.com

Florent Waltz@florentwaltz.bsky.social · 6mo ago

Long in the making, but happy to present the Chlamydomonas chlororibosome! Cryo-ET🔬reveals a large new domain on the small subunit, built from multiple extensions in conserved ribosomal proteins. bioRxiv 📖: shorturl.at/q44tG This suggests greater chlororibosome diversity than expected! 1/n 🧵

Exciting to see this study finally out!! Congrats Juan and everyone involved! 👏🏼

Juan Martin Serrano@juanmartin-serrano.bsky.social · last mo.

Very proud to see this paper out. This is an incredible collaboration with the labs of Wes Sundquist and Adam Frost. @uofubiochem.bsky.social @kingslsm.bsky.social www.nature.com/articles/s41...

Very proud to see this paper out. This is an incredible collaboration with the labs of Wes Sundquist and Adam Frost. @uofubiochem.bsky.social @kingslsm.bsky.social www.nature.com/articles/s41...

ESCRT-III assembles around mis-segregated DNA to protect genome stability - Nature Structural & Molecular Biology

The authors show that persistent ultrafine DNA bridges become coated by membranes and the ESCRT-III proteins CHMP1B and IST1, which protect the genome within from damage.

nature.com

Latest #CDlab paper: a review entitled 'Devising a divisome for synthetic cells' in Nature Reviews Chemistry www.nature.com/articles/s41... Here, 1st authors Joris Dommisse and Rafael Lira review current strategies to mimic division: symmetry breaking, constriction and abscission. Enjoy the read!

Hi #membrane folks! This is today, last talks to close this academic year's trafficking seminar season :) 👇

Ishier Raote@ishier.bsky.social · 2mo ago

Membrane Trafficking Seminar series returns with two talks on how membranes organise, move, and shape cellular life. Final session until September! Join @felixmendu.bsky.social @franbottanelli.bsky.social and me for an afternoon of cell biology at its best. felixcampelo.wixsite.com/membranetraf...

Glad to see the work of my PhD on the manchette microtubule now out in @embojournal.org: doi.org/10.1038/s443...

SPACA9 and MNMIP1 bridge the seam of spermatid manchette microtubules - The EMBO Journal

The manchette is a transient microtubule (MT)-based structure that is vital for the correct shaping of sperm during spermiogenesis. Throughout spermiogenesis, the manchette retains structural integrity for several days, raising the question of how its MTs are regulated. Here, using cryo-electron tomography of manchettes isolated from rat testes, we find that manchette MT ends are structurally diverse. We show that the MT-binding protein CLASP2 is present throughout the manchette and likely regulates both MT ends. Using cryo-electron microscopy single particle analysis and super-resolution microscopy, we reveal that SPACA9 and MNMIP1 (SH3D21) bind to the seam of manchette MTs from the luminal side. SPACA9 binds to both α- and β-tubulin of protofilament 1 but does not interact directly with protofilament 13, while MNMIP1 binds directly to protofilament 13. MNMIP1 further extends and threads through the MT lattice at the seam. Our study reveals a novel seam MT inner protein complex with a unique binding mode, providing a plausible explanation for MT regulation that maintains manchette integrity over an extended period.

doi.org

🧪🇦🇷 Excited to share our latest paper done together with Natalia Wilke, just out in Soft Matter! The take-home message: anchor lipids deserve to be treated as active membrane components when interpreting protein- and condensate-membrane interactions. doi.org/10.1039/D6SM...

NTA-Ni lipids affect membrane phase behavior and fluorescence of lipid-like dyes

The nitrilotriacetic acid group coordinated with nickel, NTA(Ni), is the standard chelator for purifying fusion proteins containing poly-histidine tags. The development of lipids with NTA(Ni) headgrou...

doi.org

@mhakala.bsky.social shows that HRS forms bidimensional condensates onto endosomal membranes to flatten clathrin/ESCRT-0, an observation unexplained since the 2000s. Thx to Kukulski lab, @stefvass.bsky.social @colomlab.bsky.social @kaksonen.bsky.social @mishakudryashev.bsky.social rdcu.be/fihKk

Very excited that our discovery of Sms1 as the #MAPK #scaffold of fission yeast mating has just been published in @natcomms.nature.com! @biology-unige.bsky.social www.nature.com/articles/s41...

With Eugene Koonin, we wrote a rather comprehensive review on the origin, evolution and organization of the #virosphere. We describe all 10 viral realms and the logic behind them, and so much more. Check it out! comptes-rendus.academie-sciences.fr/biologies/ar...

Check-out our last review about ER-contact sites and autophagosome biogenesis by @julianedagraca.bsky.social and @dobrawaamiri.bsky.social

Looking forward to sharing our latest work on the ESCRT-III complex in Asgard archaea! Hope to see many of you online!

Fran Bottanelli@franbottanelli.bsky.social · 4mo ago

#membrane seminars are back this week with @javierespadas.bsky.social from the @rouxlab.bsky.social and Chris Burd from @yalecellbiology.bsky.social! Looking forward to seeing everyone online!

New preprint! We asked a simple question: How do very different activating adaptors all activate dynein? Turns out: same architecture, wildly different implementations 🧵👇 doi.org/10.64898/202...

Huge thanks to all authors on this paper @sami-c.bsky.social @abidalilab.bsky.social and @leonmichalski.bsky.social . And to @carter-lab.bsky.social for support, guidance and the environment to do this work!

Plenty of opportunities for talks, especially for early career! Don't hesitate to send an abstract!

Raphaël Clément@raphclement.bsky.social · 4mo ago

The division Physics and Life of the French Physical Society (SFP) organizes its fourth annual meeting in Lyon, July 9th & 10th! Join us and register here: phys-life-2026.sciencesconf.org Abstract submission deadline: May 30th

The division Physics and Life of the French Physical Society (SFP) organizes its fourth annual meeting in Lyon, July 9th & 10th! Join us and register here: phys-life-2026.sciencesconf.org Abstract submission deadline: May 30th

A new family of rolling-circle replication endonucleases widespread in archaeal viruses and plasmids. This family is unrelated to the HUH superfamily Reps, but distantly related to the bacterial Rep_trans enzymes. @narjournal.bsky.social academic.oup.com/nar/article/...

Very nice work from colleagues on the nematic organization of cellular tissues👇 Great to see such a clear focus on how parameter choices influence the analysis and the conclusions we draw, together with a detailed look at defect behavior across cell types!

Claire Dessalles@clairedessalles.bsky.social · 4mo ago

All you ever wanted to know about how to analyse the nematic nature of cellular tissues is right here 👀👇🏼! Bonus #1: we did it for many cell types and uncovered unexpected defect behavior 🐌 Bonus #2: for theoreticians looking for parameter values for your simulation🧑🏼‍💻 tinyurl.com/2s399yen

European Union is that student who spends all of their time on experiments that will end up in supplements but never does the experiment that will make or break the project. 🇪🇸 is the postdoc that constantly reminds about that experiment at the lab meeting! Thank you 🇪🇸

All you ever wanted to know about how to analyse the nematic nature of cellular tissues is right here 👀👇🏼! Bonus #1: we did it for many cell types and uncovered unexpected defect behavior 🐌 Bonus #2: for theoreticians looking for parameter values for your simulation🧑🏼‍💻 tinyurl.com/2s399yen

Bridging the lipid divide: archaeal ESCRT-III binds phosphoinositol and polarises the cytokinetic membrane www.biorxiv.org/content/10.6...

Just published in @science.org 🚀 By controlling how cells align, we show that living nematic tissues can be programmed to generate forces and fold into predictable 3D shapes. A new platform for tissue engineering and the design of smart active materials! 🫆 www.science.org/doi/10.1126/...

Pau Guillamat@pauguillamat.bsky.social · last yr.

New preprint out! We show how cellular nematic order can be harnessed to program tissue-wide force fields and guide 3D shape transformations. The tissue morphogenesis logic, now engineered into living, programmable materials. www.biorxiv.org/content/10.1... #ActiveMatter #TissueEngineering

We offer a PostDoc position for a fully funded project on lipid-encoded #lipidtime protein quality-control checkpoints at the Golgi: great collaborators, excellent working & living conditions & benchspace with a view ;) Please share and repost!

Tardigrades resist heavy DNA damage by actively repairing such lesions & expressing DNA-protective proteins. Yet, they are not immortal. How & why do they die? @morielab.bsky.social now shows that their Achilles' heel is DNA replication: duplicating your DNA... will kill you doi.org/10.1111/febs...

FEBS Press

DNA damage in the tardigrade Hypsibius exemplaris elicits distinct cellular outcomes depending on replication status. While non-replicating cells tolerate genotoxic stress, constitutively replicating...

doi.org

I am excited to share our most recent work collaborating with @centriolelab.bsky.social and @stearnslab.bsky.social to look at the ciliary base of mammalian multiciliated cells w/ cryo-ET, XL/MS, and U-ExM www.biorxiv.org/content/10.6...

When DNA damage responders are not only that: @MorieLAB.bsky.social shows that, without ATM, one master kinase responding to DNA damage, the Golgi is markedly deployed. ATM phosphorylates Golgi substrates to limit Golgi extension, which matters for Golgi cargo maturation: doi.org/10.64898/202...