Alex Bisson
@archaeon-alex.bsky.social
🇧🇷🇺🇸Evolutionary Cell Mechanobiology of Archaea. Associate Professor at Indiana University. Standing tall on the shoulders of tiny (salty) bugs. Lab Website: bissonlab.com
Antibiotic resistance isn't just a genetic problem; it's ecological. New research from #HHMIInvestigator Harmit Malik & co shows that when a dangerous bacterium shares space w/a common fungus, it can be pushed toward resistance it wouldn't develop alone — but with a built-in weakness bit.ly/4g1jLnZ
Yet another myth collapses and joins Ethidium Bromide. Next one will be "having dedicated RNA bench and pipettes" journals.asm.org/doi/10.1128/...
As a component of aseptic technique, Bunsen burners do not universally decrease deposition of microbe-containing particles | Microbiology Spectrum
The ability to manipulate and control microbial presence in built environments is imperative to research and medicine. The lack of documented evidence relating Bunsen burner use and airborne contamina...
journals.asm.org
A call out to our former postdoc John Mallon (not in social media), who contributed to both device development and “biology” :). John evolved a salt-loving archaeon to love salt a bit less (2.6M down to 1.3M!). Cells recovered growth rate AND cell morphology. Congrats Phil, Sebastian, and John!
Sebastian S. Cocioba@atinygreencell.bsky.social · 3mo ago@breakliquid.bsky.social and I are delighted to say our OpenEVO preprint is finally live! An open source hand-made turbidostat that's modular, affordable, and made to be customized. Designed with love for the research community. Enjoy!!!💚 www.biorxiv.org/content/10.6...
"Curiosity-driven research is really the seed corn for the major breakthroughs and applications. But it’s also important in its own right, because discovery and the expansion of knowledge are virtues in themselves." Thanks @neilshubin.bsky.social (gift article) www.nytimes.com/2026/06/12/s...
Neil Shubin on Trusted Science in a ‘Deeply Partisan Age’
nytimes.com
So cool! I watched this 10x in a row.
Katrina Velle@katrinavelle.bsky.social · 4mo agoAfter a long hiatus, happy #MicroscopyMonday! Here are some amoebae squeezing themselves into narrow channels (part of a video for our preprint pubmed.ncbi.nlm.nih.gov/41377514/). Sound effects by Dillon (my 4 month old who may have had a little to do with the bluesky hiatus!)
Yes definitely! As a starting point, our lab had compiled a database of dynamics measurements for various TFs obtained through SMT, FRAP, FCS etc. (www.mir-lab.com/dynamics-dat...) and we want to continue to expand it.
Dynamics Database | Mustafa Mir Lab | United States
Compilation of protein dynamics data from literature
mir-lab.com
1/🧵 Can transcription factor condensate formation be explained without phase separation? Our new preprint introduces SPARK, a simulation tool that reproduces condensate behavior (clustering, fusion, FRAP) from diffusion & binding kinetics alone. Movie: 60 sec FRAP sim www.biorxiv.org/content/10.6...
Thank you, we hope people use it to think about condensates in various systems! SPARK isn’t sequence-based but rather works by modulating kinetic parameters (diffusion coeff, binding probability, residence time etc.) which does affect properties like brightness and persistence of condensates (Fig 1)
The Bisson Lab at IU (bissonlab.com) is hiring makers/builders/engineers across all career stages to join our team in one of the most exciting and crazy projects I've set to work on. Candidates can email us: saltylab@iu.edu More info in the thread [1/3]
Discussion Meeting of the VAAM special group "Microbial Cell Biology" October 5–7, 2026 | Marburg, Germany More information: mcb2026.eventbrite.com
I'm moving to Purdue University as a tenured professor this summer! Excited to hire postdocs there and get a lab up and running with @runxishen.bsky.social as co-lead. More details: www.linkedin.com/posts/anneca...
I'm thrilled to announce I'm joining Purdue University as a tenured professor this August! Purdue holds a special place in my heart: its undergraduate program prepared this Indiana farm girl…...
I'm thrilled to announce I'm joining Purdue University as a tenured professor this August! Purdue holds a special place in my heart: its undergraduate program prepared this Indiana farm girl remarkab...
linkedin.com
"Elsevier incurred costs of around £1.7 billion last year, which included investment to develop new technology and for improving services." Let that sink for a min. $1.7B expenses ($2.7B revenue and $1B profit) and they expect us to believe they're developing any sorts of technology.
Richard Sever@richardsever.bsky.social · 6mo agoElsevier costs were ~£1.7B in 2025 newsletter.journalology.com/p/elsevier-2... Compare that to arXiv 👇
We had covered the history of traction force microscopy (TFM) earlier: bsky.app/profile/epim... But what about applying TFM into more physiologically relevant systems, such as those in 3D? I am @barrasa-fano.bsky.social and I'll be your guide through this thread on #3DTractionForceMicroscopy.
HALOPHILES YESSSSSSSS
Diorge Souza@diorgeps.bsky.social · 7mo agoA new preprint from the @archaeon-alex.bsky.social and Joey Davis (MIT) labs! We solved the structure of the ribosome from the archaeon Haloferax volcanii and discovered a new highly conserved ribosome hibernation factor that we named AHA (AMPKγ–HPF from Archaea) 🧵⬇️ www.biorxiv.org/content/10.6...
Can't miss this amazing study on the ribosome structure of the Haloferax archaeon 👏🏼👏🏼👏🏼!! Congrats to my good friend @diorgeps.bsky.social and all the other ppl involved!!
Diorge Souza@diorgeps.bsky.social · 7mo agoA new preprint from the @archaeon-alex.bsky.social and Joey Davis (MIT) labs! We solved the structure of the ribosome from the archaeon Haloferax volcanii and discovered a new highly conserved ribosome hibernation factor that we named AHA (AMPKγ–HPF from Archaea) 🧵⬇️ www.biorxiv.org/content/10.6...
Another paper on a topic we never worked on before: a new ribosomal hibernation! Under the leadership of the super-postdoc Diorge, Davis Lab (ribo-cryoEM master), and @vikramalva.bsky.social (protein-evo whisperer), we identified AHA (not the song, but archaeal hibernation AMPKγ factor). (1/2)
Diorge Souza@diorgeps.bsky.social · 7mo agoA new preprint from the @archaeon-alex.bsky.social and Joey Davis (MIT) labs! We solved the structure of the ribosome from the archaeon Haloferax volcanii and discovered a new highly conserved ribosome hibernation factor that we named AHA (AMPKγ–HPF from Archaea) 🧵⬇️ www.biorxiv.org/content/10.6...
Very cool work led by @diorgeps.bsky.social from the labs of @archaeon-alex.bsky.social & Joey Davis (MIT)! They solved the Haloferax volcanii ribosome and characterize AHA, a conserved archaeal hibernation factor. With several recent related preprints, it’s an exciting moment for the field!
Diorge Souza@diorgeps.bsky.social · 7mo agoA new preprint from the @archaeon-alex.bsky.social and Joey Davis (MIT) labs! We solved the structure of the ribosome from the archaeon Haloferax volcanii and discovered a new highly conserved ribosome hibernation factor that we named AHA (AMPKγ–HPF from Archaea) 🧵⬇️ www.biorxiv.org/content/10.6...
Excited to share this new Preprint from our lab led by PhD Candidate Carl Stone (defending Tuesday). Here we present a framework for longitudinal rbTn-Seq and apply it to the Microbial extended growth curve to resolve the fitness seascape through growth, death, and long-term stationary phase!
bioRxiv Evolutionary Biology@biorxiv-evobio.bsky.social · 8mo agoBayesian analysis of longitudinal RB-TnSeq resolves the fitness seascape in fluctuating environments https://www.biorxiv.org/content/10.64898/2026.02.11.703069v1
🚨 Alarm!!! 🚨 AI/ML course for microscopy image analysis!!! 🧐 In 2026 at Janelia (@hhmijanelia.bsky.social), no tuition, housing and meals provided! Isn’t that borderline unbelievable?!? 20 students, ~14 TAs and lecturers 🗓️ June 4-18 2026 ✍️ Jan 15 2026 ✍️ 🔁 pls!! www.janelia.org/you-janelia/...
Deep Learning for Microscopy Image Analysis
Topics The following will be covered extensively during lectures, exercises, and project work: Image denoising and restoration (fully supervised and self-supervised) Image translation (e.g.,
janelia.org
Another #notTHECover unfortunately. But this gorgeous, Tron-like vibe, drawn by the amazing @munafomarzia.bsky.social for our recent #ExM work with @gautamdey.bsky.social & @centriolelab.bsky.social will still be printed out in the lab. Read here: www.cell.com/cell/fulltex...
I am beyond excited to announce that the Bisson Lab has a new home!!! Starting January 2026, I will join the Biology Department at Indiana University Bloomington as Associate Professor with tenure. I am actively recruiting scientists across all levels. More in our website: bissonlab.com/join [1/4]
I am (months) late, but you HAVE TO read @huepfkiesel.bsky.social (there is an update version). How can ParM "turned MreB” in cyanos? shorturl.at/JXMjy This will become a classic. Such a clear example of homology =/= function. We need more studies to collect larger sample sizes to test it.
Repurposing of a DNA segregation machinery into a cytoskeletal system controlling cell shape
Bacteria, like eukaryotes, use conserved cytoskeletal systems for intracellular organization. The plasmid-encoded ParMRC system forms actin-like filaments that segregate low-copy plasmids. In multicel...
shorturl.at
Episode 17 - perhaps my favorite yet. How do you write a forum.image.sc post that will get you the answers you need without revealing information you don't want to tell? @erinweisbart.bsky.social and I go through what the experts need to know to help you. Post your sci q's today on forum.image.sc !
How to Write a Great Post on the Image.sc Forum - AskErinDearBeth Episode 17
YouTube video by Ask Erin, Dear Beth
youtu.be
Beth Cimini 🔬💻📊@bethcimini.bsky.social · 12mo agoEpisode 16 - Learn more about the Cell Painting Gallery, a free repository of nearly a petabyte of images and imaging data, curated by the incredibly talented @erinweisbart.bsky.social . Truly a goldmine for big-data lovers everywhere!
I’ve been regularly volunteering at a food bank for about a year and please, if you want to help, consider donating cash. For $3, they can provide 15 meals and what they can do with the money you might spend on a few cans can be converted to vastly more in fresh fruit, vegetables, dairy, or meat.
"Electroboy" is my memoir about my battle with bipolar disorder and which is being made into a feature film with Timothee Chalamet. The book is out of print - I have h/c and p/b copies which I inscribe to you and ship overnight to you. The cost is $30 for a h/c and $20 for a p/c - send me a DM!
This is one of my fav bac cell div papers. It's remarkable how much we've learned about cytokinesis in the past decade, and how much we still don't know. This paper harmonizes many of the disagreements in the field, like what limits construction rates (1/4)
Ethan Garner@fleshball.bsky.social · last yr.I’m excited that the work by Diego Ramirez and Lei Yin is out, where they gained several key insights into what provides the force underlying bacterial cell division doi.org/10.1101/2025.... To divide, cells must first bend the membrane inward, a process that’s energetically expensive
It bears repeating that nearly the entire US enterprise in science and technology has been irreversibly gutted. This is shocking. All this loss has occurred without any real benefit to the average US citizen. Except we now have the biggest, best funded secret police force perhaps ever. Yay for us!
Collective cell motion has many forms, but rotation is the coolest of them all. I'm @onenimesa.bsky.social , and in this short🧵, I'll highlight some instances of global tissue rotation like this one from @BauschLab