Daniel Jost - Physical Biology of Chromatin group
@djost-physbiol.bsky.social
CNRS Research Professor - Group Leader at Laboratory of Biology and Modeling of the Cell, Ecole Normale Supérieure de Lyon. Physical biology of chromatin: modeling the spatio-temporal dynamics of eukaryotic genomes.
Great collaboration with Yvert's lab on the kinetic characterization of a light-inducible Cre recombinase. This is the basis of future exciting works. Stay tuned 😉 journals.biologists.com/bio/article/...
Kinetic properties of optogenetic site-specific DNA recombination by LiCre-loxP
Summary: We characterize the properties of LiCre, which, in response to blue light, can switch on or off whatever gene is close to a specific DNA sequence called LoxP.
journals.biologists.com
Happy to share our new review! Chromatin mechanics and regulatory protein function: insights from single-molecule force spectroscopy www.sciencedirect.com/science/arti...
Chromatin mechanics and regulatory protein function: insights from single-molecule force spectroscopy
Single-molecule force spectroscopy probes chromatin mechanics by resolving force-induced conformational transitions across multiple length scales. Rec…
sciencedirect.com
Happy to share our review of the past, recent, and future applications of synthetic genomics in studying the 3D functional organization of chromosomes, a set of approaches that are gaining momentum! www.sciencedirect.com/science/arti...
Synthetic chromosomes for 3D functional genomics: from principles to AI-guided design
The role of genome 3D organization for fundamental chromatin processes, such as long-range promoter-activator regulatory interactions, remains ambiguo…
sciencedirect.com
Our work on the interplay between loop extrusion and chromatin mechanics is finally out in @physrevresearch.bsky.social . Congrats @hosseinsalari.bsky.social for the hard work ! 👏 journals.aps.org/prresearch/a...
Active loop extrusion modulates the mechanical response of chromatin under tension
Chromosomes are complex biopolymers folded into dynamic loops via a loop-extrusion process and may experience various mechanical forces in vivo. We develop a force-dependent model of chromatin loop ex...
journals.aps.org
Daniel Jost - Physical Biology of Chromatin group@djost-physbiol.bsky.social · 10mo agoNew preprint from the lab !! Loop extrusion may provide mechanical robustness to chromatin. Great work by Hossein Salari. @cnrs.fr @lbmcinlyon.bsky.social www.biorxiv.org/content/10.1...
Happy to share our Current Opinion review on the key challenges in accurately predicting 3D distances between chromatin segments and computing their dynamics. Thanks to @djost-physbiol.bsky.social @lucagiorgetti.bsky.social for the invitation to write this review! @shuvadipdutta.bsky.social
Thanks also to @lucagiorgetti.bsky.social and @djost-physbiol.bsky.social for the invitation and for putting together a very interesting themed issue - the other reviews in the issue can be found here www.sciencedirect.com/special-issu...
Current Opinion in Genetics & Development | Genome Architecture and Expression (2026) | ScienceDirect.com by Elsevier
This collection summarizes key aspects of our current experimental and theoretical understanding of eukaryotic genome folding and its relationship with the molecular processes governing cell fate. Ove...
sciencedirect.com
🚨SUMOylation regulates the formation and function of Polycomb foci. New preprint from Cavalli lab where we performed modeling: SUMOylation regulates the PRC1 self-attractions mediating PcG condensate. Look at the preprint 👇https://www.biorxiv.org/content/10.64898/2026.02.05.704038v1
biorxiv.org
TSA treatment may induce cellular and structural memory !! Happy to have been part of this beautiful story, lead by @fpaldi.bsky.social in Giacomo Cavalli's lab. Now published in @natgenet.nature.com 👏. www.nature.com/articles/s41...
Transient histone deacetylase inhibition induces cellular memory of gene expression and 3D genome folding - Nature Genetics
Acute perturbation of histone acetylation induces changes in chromatin organization that are only partially reversed once the perturbation is removed and are associated with transcriptional memory eff...
nature.com
🚨 New preprint from the lab. Combining modeling and data analysis of SisterC data in yeast, we investigate cohesion of replicated chromosomes and show that sister chromatids are loosely and asymmetrically aligned in G2/M. Check the tweetorial below ⬇️ www.biorxiv.org/content/10.6...
biorxiv.org
SMC and recombination enthusiasts: we updated our work describing the loop extrusion properties of budding yeast condensin and its function in biasing donor usage for mating-type switching. Lots of cool new data, check it out! www.biorxiv.org/content/10.1...
Our Mini Review went online last night in Current Opinion in Genetics & Development "Block copolymer concepts of how transcription organizes the stem cell genome" doi.org/10.1016/j.gd... Fig. 1: Stem cell–typical organization of the genome and transcription, and the block copolymer sorting concept.
🚨Our work on the impact of DNA replication on 3D genome is out in Genome Biology: replication-dependent loop extrusion by sister-forks, wave of replication, no evidence for large-scale replication factory. Great collab with @aurelepiazza.bsky.social. More here: link.springer.com/article/10.1...
Genome-wide modeling of DNA replication in space and time confirms the emergence of replication specific patterns in vivo in eukaryotes - Genome Biology
Genome Biology - Although significant progress has been made in our understanding of DNA replication and spatial chromosome organization in eukaryotes, how they interplay remains elusive. In...
link.springer.com
Daniel Jost - Physical Biology of Chromatin group@djost-physbiol.bsky.social · last yr.🚨 new preprint from the lab. Combining modeling, new Hi-C data in yeast and data analysis, our study offers new insights into the spatial and dynamic organization of chromatin during replication in eukaryotes. Check the tweetorial below ⬇️ www.biorxiv.org/content/10.1...
BIG ANNOUNCEMENT📣: I haven’t been this excited to be part of something new in 15 years… Thrilled to reveal the passion project I’ve been working on for the past year and a half!🙀🥳 (thread 👇)
New preprint from the lab !! Loop extrusion may provide mechanical robustness to chromatin. Great work by Hossein Salari. @cnrs.fr @lbmcinlyon.bsky.social www.biorxiv.org/content/10.1...
Loop extrusion provides mechanical robustness to chromatin
Chromosomes are complex biopolymers folded into dynamic loops via a loop extrusion process and may experience various mechanical forces in vivo . We develop a force-dependent model of chromatin loop e...
biorxiv.org
"A la découverte des chromosomes", la conférence immersive imaginée par @djost-physbiol.bsky.social est en ligne sur la chaine Youtube du CNRS. www.youtube.com/watch?v=CHh_... @cnrsbiologie.bsky.social @cnrs-rhoneauvergne.bsky.social @ensdelyon.bsky.social
À la découverte des chromosomes | Conférence immersive | Les Échappées inattendues
YouTube video by CNRS
youtube.com
🚨 new preprint from the lab. Combining modeling, new Hi-C data in yeast and data analysis, our study offers new insights into the spatial and dynamic organization of chromatin during replication in eukaryotes. Check the tweetorial below ⬇️ www.biorxiv.org/content/10.1...
Genome-wide modeling of DNA replication in space and time confirms the emergence of replication specific patterns in vivo in eukaryotes
Although significant progress has been made on our understanding of DNA replication and spatial chromosome organization in eukaryotes, how they both interplay remains elusive. In particular, from the ...
biorxiv.org
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