Recombination enthusiasts, mark your calendar for this great conference held in Portugal next summer !

Fusion Conferences@fusionconf.bsky.social · last wk.

Delighted to announce #RecombMechanisms is back for its 3rd edition next July! This conference will bring together leaders in the fields of DNA recombination (mitotic & meiotic), repair, replication, transcription, epigenetics, and cancer biology. Sign up for updates now➡️https://bit.ly/4pFcLAq

We recently developed ssHiC, a broadly applicable technique to study contacts made by ssDNA in cells. Here we present ssHicstuff, an open-source package to design and analyze ssHiC data. Paper: academic.oup.com/bioinformati... GUI online: tinyurl.com/sshicstuff Github: github.com/Piazzalab/ss...

The new #Yeast issue of January-March 2026 (Volume 43, Number 1-2) is now out, with a review on the role of Rad9 in DNA repair, and three research articles spanning the isolation of yeast species from flowers and honeys, and the effects of furanic compounds. onlinelibrary.wiley.com/doi/10.1002/...

Issue Information

No abstract is available for this article.

onlinelibrary.wiley.com

How diverse is bacterial immunity ? We report in @science.org how language models allowed us to predict 2.4M antiphage proteins spanning >23K novel potential systems. 👏 @emordret.bsky.social, @alexhv.bsky.social & al doi.org/10.1126/scie... Explore them here defensefinder.mdmlab.fr/wiki/refseq_...

Ever wondered how a eukaryotic transcription factor finds its specific DNA motif in the vast genome? In this preprint, we directly measured the dynamics of this search process in living cells, revealing a cooperative mechanism mediated by disordered regions. 1/10 doi.org/10.64898/202...

Delighted to see our work now published at the EMBO Journal! Check also this concomitant paper by the Bai and Mirny labs with an orthogonal approach that aligns well with our measurements www.nature.com/articles/s41... Great system to study how SMCs facilitate/regulate target search in chromatin!

The EMBO Journal@embojournal.org · 5mo ago

Condensin loop extrusion properties, roadblocks, and role in homology search @aurelepiazza.bsky.social et al show yeast condensin unidirectionally extrudes long chromatin loops & contributes to biasing donor selection during recombinational DNA break repair link.springer.com/article/10.1...

Encouraging and full of hope: this study shows that even species on the brink of extinction can regain lost genetic diversity and recover over time. www.science.org/doi/10.1126/...

Escaping bottlenecks: The demographic path to genetic recovery in koalas (Phascolarctos cinereus)

Population bottlenecks can lead to evolutionary dead ends by eroding genetic diversity and intensifying inbreeding. Although theory predicts possible escape routes, direct observations of this process...

science.org

The Expanding Roles of Homologous Recombination Proteins in Genome Stability @labvincenzo.bsky.social review how RAD51 shields DNA from nucleolytic processing, promotes fork reversal, suppresses replicative DNA gaps, binds abasic sites to avert cytotoxic conversion link.springer.com/article/10.1...

📣 16th edition of the French 3R meeting “Replication, Recombination, Repair” - Registrations are open! 📆 May 18 to 21, 2026 📍 Belambra Club Presqu’île du Ponant in La Grande-Motte, France 🔗 www.2026.3r-meeting.fr/page/home/

Very excited to announce the FIRST symposium on epigenome editing! These tools are becoming widely used in mol bio, ag & therapy. It's time to bring leaders together to discuss this rapidly growing and exciting field. And why not in Paris! Please register & share! (1/2) ctrlepiedit.sciencesconf.org

We just published a short conceptual review together with @angela-taddei.bsky.social on the spatial controls of homology search in both bacteria and eukaryotes. We discuss an emerging framework for homology search in cells with two main phases. Check it out: authors.elsevier.com/c/1mjyh,LqAZ...

SMC and recombination enthusiasts: we updated our work describing the loop extrusion properties of budding yeast condensin and its function in biasing donor usage for mating-type switching. Lots of cool new data, check it out! www.biorxiv.org/content/10.1...

A cool genetic system to study site-pecific replication fork collapse and repair from the brilliant @winterhalterlab.bsky.social www.nature.com/articles/s41...

Rescuing the bacterial replisome at a nick requires recombinational repair and helicase reloading - Nature Communications

DNA damage can lead to cell death. Here, the authors show that a simple cut on either strand of DNA can inactivate bacterial chromosome replication. Surprisingly, only a core set of recombination prot...

nature.com

🚨Our work on the impact of DNA replication on 3D genome is out in Genome Biology: replication-dependent loop extrusion by sister-forks, wave of replication, no evidence for large-scale replication factory. Great collab with @aurelepiazza.bsky.social. More here: link.springer.com/article/10.1...

Genome-wide modeling of DNA replication in space and time confirms the emergence of replication specific patterns in vivo in eukaryotes - Genome Biology

Genome Biology - Although significant progress has been made in our understanding of DNA replication and spatial chromosome organization in eukaryotes, how they interplay remains elusive. In...

link.springer.com

Daniel Jost - Physical Biology of Chromatin group@djost-physbiol.bsky.social · last yr.

🚨 new preprint from the lab. Combining modeling, new Hi-C data in yeast and data analysis, our study offers new insights into the spatial and dynamic organization of chromatin during replication in eukaryotes. Check the tweetorial below ⬇️ www.biorxiv.org/content/10.1...

Thrilled to share that my postdoc research is published today in @science.org! We found that DNA repair uses cohesin complexes to build new chromatin loops that guide the homology search and boost accurate repair! 1/n www.science.org/doi/10.1126/...

Cohesin drives chromatin scanning during the RAD51-mediated homology search

Cohesin folds genomes into chromatin loops, the roles of which are under debate. We found that double-strand breaks (DSBs) induce de novo formation of chromatin loops in human cells, with the loop bas...

science.org

I am happy to share that my postdoctoral work in the @gerlichlab.bsky.social at @imbavienna.bsky.social is finally out 🎉! Our study reveals how cohesin guides focused and accurate homology search. Read more 👉 www.science.org/doi/10.1126/... Follow along for key insights and updates! 🧵

Cohesin guides homology search during DNA repair using loops and sister chromatid linkages

Accurate repair of DNA double-strand breaks (DSBs) is essential for genome stability, and defective repair underlies diseases such as cancer. Homologous recombination uses an intact homologous sequenc...

science.org

The 21st Course on Epigenetics which will take place from March 25th to April 1st, 2026 at the Institut Curie (Paris). The Course is open to M2 and PhD students. Application via the Advanced Training Office website before December 15th, 2025 at: minilien.curie.fr/3avv47

Nature research paper: From genotype to phenotype with 1,086 near telomere-to-telomere yeast genomes go.nature.com/4nVsl9z

From genotype to phenotype with 1,086 near telomere-to-telomere yeast genomes - Nature

A newly compiled atlas of species-wide structural variants and gene-based and graph pangenomes derived from highly complete assemblies of genomes from 1,086 natural isolates enable integrative genome-scale studies of Saccharomyces cerevisiae.

go.nature.com

excellent read. www.embopress.org/doi/full/10....

For the love of frontier research, or why Elon’s rockets keep blowing up | EMBO reports

EMBO Press is an editorially independent publishing platform for the development of EMBO scientific publications.

embopress.org

A three-year PhD position is available within the team, starting no later than October 2026, to decipher the molecular signatures of chromosomal instability in response to replication stress and how nuclear architecture shapes these signatures in yeast. Please RT. fr.scribd.com/document/934...

Offer PhD Position Team Lambert | PDF | Genetics | Life Sciences

3-year PhD offer in biology to mechanisms of complex rearrangements of the genome.

fr.scribd.com

Happy that the final version of our Lamassu work @yli18smc.bsky.social is now out: www.nature.com/articles/s41... Thanks again to our awesome collaborators @mblokesch.bsky.social and David and co and Mark Szczelkun and @steven-shaw.bsky.social and the DCI Lausanne @fbm-unil.bsky.social

Stephan Gruber@gruberlab.bsky.social · last yr.

Glad to share the work of @yli18smc.bsky.social and co on Lamassu, a bacterial defense system related to Rad50/Mre11 (RM). While RM carefully trims DNA ends for repair, Lamassu chops up the host chromosome. Our study reveals how it is regulated to minimize damage, activating only during infection.

New preprint from the lab !! Loop extrusion may provide mechanical robustness to chromatin. Great work by Hossein Salari. @cnrs.fr @lbmcinlyon.bsky.social www.biorxiv.org/content/10.1...

Loop extrusion provides mechanical robustness to chromatin

Chromosomes are complex biopolymers folded into dynamic loops via a loop extrusion process and may experience various mechanical forces in vivo . We develop a force-dependent model of chromatin loop e...

biorxiv.org

PREACH! www.nature.com/articles/s41...

Reaffirming the value of model organisms in training scientific minds - Nature Cell Biology

As biomedical research prioritizes human models and translational promise, classic model organisms are increasingly dismissed. Here we argue that they have a lasting value, both in enabling discovery and in cultivating scientific thinking, by training researchers in systems reasoning, integrative thinking and independent inquiry.

nature.com

A thought-provoking piece!

@Bernard-S-Lopez.bsky.social@bernard-s-lopez.bsky.social · 11mo ago

Plot twist: homologous recombination actually promotes the development of cancer! This discussion has been started in the hope that it will be useful, see the link: doi.org/10.1038/s413...

🍽️🧬 How do diet and gut microbes shape fertility across generations? 🪱🔬 Our Laboratory at #InstitutPasteur is recruiting a PhD student to study epigenetic inheritance of fertility using C. elegans. Fully funded via the International PPU program. Apply now! 🌍 #PhDposition #Epigenetics #Inheritance

Institut Pasteur | 130 years of biomedical research@pasteur.fr · 11mo ago

🎓 Applications for Institut Pasteur's PhD programs open Sept 1-Oct 20, 2025 for October 2026 entry. Apply to up to 4 projects across 6 programs: PPU, PPU-IMAGINE @institutimagine.bsky.social, PPU-@ox.ac.uk, PPU-EID @upcite.bsky.social & more 🧬 Register now ✍️ www.pasteur.fr/en/education...

Is euchromatin really “open”? Our new study @bioRxiv suggests otherwise. Using super-resolution imaging @shiori-iida.bsky.social‬ @masaashimazoe.bsky.social reveals: Euchromatin forms condensed domains in live cells. Cohesin constrains them and prevents domain mixing. www.biorxiv.org/cgi/content/...

Our paper is now out in Molecular Cell! Check the thread in this former post: www.cell.com/molecular-ce...

Chromatin architecture mapping by multiplex proximity tagging

Delamarre et al. develop a technology named PCP that can simultaneously map complex spatial relationships between millions of molecules. Using PCP, they investigate chromatin structure and describe si...

cell.com

Axel Delamarre@axeldelamarre.bsky.social · last yr.

Hi everyone! The latest method from the Whitehouse lab: PCP 
PCP uses a novel proximity barcoding strategy to simultaneously map 3D genome organization at various resolutions at the single molecule level: Out soon, check the updated BioRxiv – little thread: 1/11 www.biorxiv.org/content/10.1...

Transcription and recombination are two universal DNA-dependent processes, but how they are coordinated remains largely unknown. Here we characterized transcription-recombination priority rules in yeast. 🧵 www.embopress.org/doi/full/10....

Are you ready for the 2nd half of 2025? Social DNAing is ready. Check out the speaker list and schedule! Sign up at www.cancer.columbia.edu/research/pro...

1/ Super excited to share my first preprint from @andersshansen.bsky.social Lab! We used MINFLUX to track chromatin (H2B-Halo and Fbn2 locus) at an unprecedented 200 μs, then combined it with SPT to span μs-minutes (H2B) or SPT & Super-Res Live-Cell Imaging (SRLCI) to span μs-hours (Fbn2)