We are also conducting an open-area search for a tenure-track assistant professor in neuroscience. Please consider applying or forward to others who may be interested. psychology.uiowa.edu/about/job-op...

How does the brain represent the value of knowledge? In our paper--out now at Nature Neuroscience--we identify a representation of intrinsic information value within neural population structures in the orbitofrontal cortex in mice. www.nature.com/articles/s41593-026-02377-y #neuroskyence 🧠🧪 (1/8)

Representations of the intrinsic value of information in mouse orbitofrontal cortex - Nature Neuroscience

Mice are motivated to seek information of no extrinsic value. Recording neural activity in orbitofrontal cortex reveals a representation of the value of information that is distinct from the value of ...

nature.com

📣New paper! How does the sleeping brain help us to integrate new experiences while managing memories from the past? For his PhD work, @sabbaspoor.bsky.social recorded hippocampal ensembles in freely moving monkeys and found something unexpected. 🧵1/n www.nature.com/articles/s41... 🧪🧠📈👩‍🔬#OpenAccess

Experience reorganizes content-specific memory traces in macaques - Nature Neuroscience

In macaques, old memories, relative to new ones, are supported by more stable and interconnected cell assemblies. New-biased and old-biased assemblies reactivate during overnight sleep and can sometim...

nature.com

As promised (and only slightly late 😅): here's a figure-by-figure walk-through of our preprint "Random network structure stabilizes neural manifolds". This one is a bit more for the nerds. For an overview version 👉 bsky.app/profile/j-b-... Preprint: doi.org/10.64898/202... 1/8 🧠🧪

Random network structure stabilizes neural manifolds

Neuronal activity patterns change continuously over days and weeks, a phenomenon known as representational drift. Despite this, the geometric structure of population representations, namely the pairwise similarities between stimulus-evoked activity patterns, remains remarkably stable. How can ongoing changes in activity be consistent with stable representational similarity? We show that this is a generic consequence of random connectivity: in networks with random connectivity, output similarity is a monotonically increasing function of input similarity, independent of the specific connectivity pattern. Drift, whether driven by random synaptic turnover or Hebbian plasticity, merely transitions the network between random instantiations, leaving similarity intact. This extends to recurrent architectures and to deep neural networks, where continued training beyond performance saturation produces activity drift while preserving representational similarity. Although connectivity in the brain is not random, networks trained on high-dimensional inputs acquire connectivity that behaves statistically like a random projection, making these results broadly applicable to biological neural circuits. ### Competing Interest Statement The authors have declared no competing interest. Spanish Ministry of Science and Innovation, PCI2023-145967-2, PID2021-124702OB-I00 Spanish State Research Agency (AEI) – Severo Ochoa and María de Maeztu Program for Centers and Units of Excellence in R&D, CEX2020-001084-M German Research Foundation (DFG), FOR 5368 ARENA

doi.org

Jens-Bastian Eppler@j-b-eppler.bsky.social · 2mo ago

New preprint: Random network structure stabilizes neural manifolds We’re excited to share our new work on representational drift. doi.org/10.64898/202... Representational drift poses a puzzle. 👇 A short thread below. In the next days a figure by figure walk through will follow. 1/5 🧪🧠

My postdoc is coming to an end, so I'm looking for work! Let me know if you, or anyone you know, wants to hire a philosopher of biology/cognition with a knack for cross-disciplinary work, a focus on autonomy + agency, and experience writing for the broader public (10+ yrs in sci/tech journalism).

**Four** positions in AI/ML for biology at @dukemedschool.bsky.social, including in Neurobiology. @scottsoderling.bsky.social and David Page are leading a tremendous initiative in Discovery AI. Wonderful colleagues, wonderful place.

AI/ML for Biology - 4 tenure-track assistant professor positions - Durham, North Carolina job with Duke University - Biochemistry & Cell Biology | 12862109

Discovery AI Initiative and Departments of Biochemistry and Cell Biology, Integrative Immunobiology, Neurobiology, and Pharmacology & Cancer Biology

nature.com

Excited to finally share our new paper in @natcomms.nature.com: Hippocampal ripples initiate cortical dimensionality expansion for memory retrieval www.nature.com/articles/s41... With @s-michelmann.bsky.social and @doellerlab.bsky.social

Hippocampal ripples initiate cortical dimensionality expansion for memory retrieval - Nature Communications

How past experiences are reconstructed from memory remains unclear. Here the authors used intracranial EEG to show that hippocampal ripples reshape the geometry of cortical representations, supporting...

nature.com

Looking to work with a postdoc. Prior experience with fMRI and computational modeling required, interest in psychiatry desired. Fellowship provides three years salary plus independent travel/equipment funds. Send CV and 2-3 manuscripts (preprints OK).

From a great collaboration with @lorenzoposani.com, @shuqiw.bsky.social, Samuel Muscinelli, Liam Paninski, now in Nature: www.nature.com/articles/s41...

Rarely categorical, highly separable representations along the cortical hierarchy - Nature

Cortical circuits prioritize diversity over categorical structure, supporting a computational regime geared towards high-dimensional, highly separable neural representations.

nature.com

New preprint from the lab! “A number simplex in the human medial temporal lobe” led by @hanlin-zhu.bsky.social 🧵 www.biorxiv.org/content/10.6...

A number simplex in the human medial temporal lobe

Humans handle numbers nimbly, suggesting a richer neural manifold structure than the prevalent mental number line model. In populations of medial temporal lobe (MTL) neurons in humans performing two s...

biorxiv.org

Our reply: the framework systematizes empirical practice; it's not an account of the nature of representation. Whether a neural response represents a feature is settled by comparing hypotheses, not an absolute evidence threshold. And this holds independently of questions about consciousness. (3/3)

Grateful for the chance to clarify our framework: our reply to Overgaard & Kirkeby-Hinrup's "Boundary issues for multidimensional frameworks of representation" — a comment on our Perspective on the conceptual dimensions of representation, in Nature Reviews Neuroscience: rdcu.be/frSNr (1/3)

New lab paper ! "Shared neural geometries for bilingual semantic representations in human hippocampal neurons" led by @xinyuanyan.bsky.social. 🧵 www.sciencedirect.com/science/arti...

Shared neural geometries for bilingual semantic representations in human hippocampal neurons

The human brain has the remarkable ability to comprehend and express similar concepts in multiple languages. To understand how it does so, we examined…

sciencedirect.com

New results! A new method that analyzes brain waves and spike timing together. This lets us pinpoint exactly which rhythms neurons are locking to. BAYESIAN STATE-SPACE MODEL FOR JOINT INFERENCE OF OSCILLATORY DYNAMICS AND POINT-PROCESS COUPLING doi.org/10.64898/202... #neuroscience

BAYESIAN STATE-SPACE MODEL FOR JOINT INFERENCE OF OSCILLATORY DYNAMICS AND POINT-PROCESS COUPLING

Under a range of behavioral and physiological conditions, spike times and local field potential (LFP) oscillations exhibit phase coupling within specific frequency bands. Classical measures such as sp...

doi.org

It is out and OPEN ACCESS: "The Senses: Perception and Experience" (Cambridge University Press, Elements: Philosophy of Mind, ed. by @keithfrankish.com) #PhilSky #booksky #HPBio #philosophy #cogsci www.cambridge.org/core/element...

The Senses

Cambridge Core - Philosophy: General Interest - The Senses

cambridge.org

On March 26, 2026, during a debate on violence against women in Germany’s Bundestag, left-wing MP Kathrin Gebel was repeatedly interrupted by AfD MP Martin Reichardt. She responded: “Mr. Reichardt, the clitoris has 3,000 nerve endings, and you’re still more sensitive. That’s quite an achievement.”

Learning shapes neural geometry in the primate prefrontal cortex www.nature.com/articles/s41...

Learning shapes neural geometry in the primate prefrontal cortex - Nature Neuroscience

Learning transforms prefrontal cortex activity from flexible, high-dimensional representations into compact, task-relevant and abstract codes, enabling efficient generalization of learned rules to new...

nature.com

Really excited about this work with the awesome Will de Cothi & Sarah Shipley, just out in Nature Reviews Neuroscience. We propose acetylcholine is an analogue of dopamine — tracking not reward prediction errors but state-transition prediction errors. https://doi.org/10.1038/s41583-026-01058-w

Hey all—I’m at #MCLS2026 presenting my poster Thursday: the Ecology of Proof. A ~500K-attempt corpus of sentential & FOL proofs, analyzed from a foraging perspective—tracing movement flow through the directed graph of proofs. New direction for me, same foraging lens. Come check it out!

I now have multifold confirmation: mouse studies at Janelia will wind down to be replaced by studies of fish. Wow.

What happens in the frontotemporal cortex during language production? Turns out distinct neurons represent detailed grammatical relationships between words & others track the sentences’ higher-order syntactic structure, phrase transitions & sequence @nature.com 🧪 www.nature.com/articles/s41...

Mapping the neuronal building blocks of human language with language models - Nature

Wide-scale recordings reveal neurons in the human brain that encode fundamental components of language such as the grammatical relationships between words, their parts of speech and the...

nature.com

What does it mean for one part of the brain to 'sample' another? Or to 'search' another? I've said and so have many others--but how to understand that phrase without positing a little dude rummaging around?

If you work in phil science and never sent your paper to a generalist journal (because worry your readership isn’t there), Philosophy and Phenomenological Research intends to bring more Phil science to its pages, and I have just joined as one of the editors. onlinelibrary.wiley.com/page/journal...

Philosophy and Phenomenological Research

onlinelibrary.wiley.com

Computational models are a key part of science but discovering new ones is hard! DataDIVER discovers concise models from data, which surface new mechanistic ideas and clear predictions for future experiments From Google Deepmind Neuroscience Lab + collaborators www.biorxiv.org/content/10.6...

We had a great time at Purdue! Thanks to all organisers and funders for this opportunity to carry out a unique interdisciplinary project in animal color experiences, accompanied with the right training and support. Now to get working 🧠

SPAN@socphilneuro.bsky.social · 2mo ago

We're excited to welcome our ITRC groups to Purdue this weekend for our @danafoundation.bsky.social funded workshop, featuring a session w/ @ucpews.bsky.social! Part of SPAN's mission is to provide resources to help foster intelligibility between phil & neuro + foster public engagement with science.

Directional elements: the preprints are out! 1/n Congratulations to our amazing team: biorxiv.org/content/10.6... biorxiv.org/content/10.6... biorxiv.org/content/10.6... We screened for principles governing global brain dynamics by developing a set of new methods: 1) conformal immersion microscopy;

New preprint: Random network structure stabilizes neural manifolds We’re excited to share our new work on representational drift. doi.org/10.64898/202... Representational drift poses a puzzle. 👇 A short thread below. In the next days a figure by figure walk through will follow. 1/5 🧪🧠

We're excited to welcome our ITRC groups to Purdue this weekend for our @danafoundation.bsky.social funded workshop, featuring a session w/ @ucpews.bsky.social! Part of SPAN's mission is to provide resources to help foster intelligibility between phil & neuro + foster public engagement with science.

Visual attention relies on coordinated activity across brain areas. Computational neural dynamics of goal-directed visual attention in macaques doi.org/10.1126/scia... #neuroscience

Computational neural dynamics of goal-directed visual attention in macaques

Large-scale brain activity patterns coordinate goals, perception, and memory to guide efficient visual search.

doi.org

Roll up, roll up: @riadsala.bsky.social did some more thinking about our model of visual foraging: doi.org/10.1371/jour.... It now has some shiny new parameters (absolute direction!) and it's not bad at distinguishing individual differences in strategies too. #PsychSciSky #VisionScience

FoMo: A unifying theory of visual foraging

Author summary Foraging is an important behaviour for humans and other animals, helping them to find food, habitats, and mates. It can involve searching both through visual space (such as searching fo...

doi.org