Stop 4 on the Jeremy Knowles Lecture tour was Imperial today - thank you to @diantoniogroup.bsky.social for hosting @ucllifesciences.bsky.social
Di Antonio Research Group
@diantoniogroup.bsky.social
We are a Chemical-Biology group investigating DNA structures and dynamics based at Imperial College Chemistry. https://www.imperial.ac.uk/diantonio-research-group
⭐NAR Breakthrough! ⭐ 🧬 A synthetic RNA forms a #G-quadruplex without a G-rich sequence, using a complex 3D fold and GTP as a ligand. This suggests G-quadruplexes may be far more widespread in biologically important RNAs. Read more: doi.org/10.1093/nar/... #NARBreaktrhough #RNA #StructuralBiology
🔬 #Trypanosomes process their large rRNA in a highly unusual way-by cutting it into six pieces. A new study from @schneian.bsky.social lab identified two essential proteins, TbLrRP1 and TbLrRP2, that drive this process. Read more: doi.org/10.1093/nar/... #NARBreakthrough #RibosomeBiogenesis
Impressive number of Lister community members in @clarivate.com's Highly Cited Researchers 2025. Our first shoutout to current #ListerFellows 🥇 Marco di Antonio @diantoniogroup.bsky.social 🥇 Ravi Gupta Congrats on your highly influential research 👏 clarivate.com/highly-cited...
📣 Announcement 📣 We are delighted to announce that the 2025 Supramolecular Chemistry Award 🏆 goes to Prof Dr Job Boekhoven from TU Munich. Congratulations, Job! @boekhovenlab.bsky.social Thanks @cellpress.bsky.social for generously sponsoring the award! (1/3)
It was a pleasure @mcgalanlab.bsky.social and congratulations again to Nina for the lovely viva. Next time hopefully catch up in person!
MCGalan Lab@mcgalanlab.bsky.social · 9mo agoMany congratulations to @NinaMaiAllen @BristolChem @BCS_CDT on passing her PhD viva today. Many thanks to Chris @Willis_Group and Marco @diantoniogroup.bsky.social for examining 🥳
As promised, we run the town and gown 10k! In the photos are group members @rogerrubiosanchez.bsky.social Juliette Bucci, Brian Ng, Cathrine Fan, Sebastian Krauss and Lorenzo (the old one). Thanks to all who supported us with donations to @mdukcharity.bsky.social
Independent research fellowships leading to tenured positions at the John Innes Centre. Repost = nice. Thank you very much!!!
John Innes Centre@johninnescentre.bsky.social · 10mo agoShortlisted candidates will be invited to give a seminar at the Fellows Conference, which will be held on 10 March 2026. Candidates who win Fellowships will be offered a Tenure Track Group Leader position from the outset, initially for 5 years. Find out more: www.jic.ac.uk/training-car...
With motor neurone disease (MND, aka ALS) hitting the headlines, here's a story about how two #ListerFellows @patanilab.bsky.social and @diantoniogroup.bsky.social teamed up to investigate how RNA might start aggregations and trigger disease. lister-institute.org.uk/two-lister-f...
Hey! Some group members and I are running a 10k race in Cambridge this Sunday, and raining some funds for @mdukcharity.bsky.social Please donate and share! @ceb.cam.ac.uk @pembroke1347.bsky.social sportsgiving.co.uk/sponsorship/...
SportsGiving - Entry: Lorenzo Di Michele
Lorenzo Di Michele is fundraising for charity. Visit their fundraising page to sponsor them online now!
sportsgiving.co.uk
We are hiring! We are looking for a PDRA to study the epigenetics of breast cancer dormancy using chemical biology and genomics approaches. This is a 3-year position and is aimed at chemical biologists or biologists. Please share and apply using the link below 👇👇👇 www.imperial.ac.uk/jobs/search-...
Description
Please note that job descriptions are not exhaustive, and you may be asked to take on additional duties that align with the key responsibilities ment...
imperial.ac.uk
John Iredale kicking off our annual meeting. Auditorium is packed 😀 Record attendance!
Thank you @beckyneuro.bsky.social @therad-lab.bsky.social and @thav-lab.bsky.social for kicking off our annual meeting with such inspiring insights from your research. Impressive examples of career-long commitment to a cause, opportunistic curiosity and always aspiration for clinical application 👏
Marco Di Antonio - his fantastic science is always challenging dogma, but first a bit about Italy ❤️ 🤌🤌🤌 @diantoniogroup.bsky.social
Proud to share our latest research in #NatureCommunication on #Gquadruplexes in #M_Tuberculosis as a new defense mechanism against oxidation 🔗https://www.nature.com/articles/s41467-025-62485-4 🧬🦠All-female collaboration from #DMM_Unipd #SaraNRichter_ @irenezanin.bsky.social #Tuberculosis
CUT&Tag reveals unconventional G-quadruplex landscape in Mycobacterium tuberculosis in response to oxidative stress - Nature Communications
In this study, the authors demonstrate that cleavage under targets and tagmentation (CUT&Tag) can be employed to map G-quadruplexes (G4s) in Mycobacterium tuberculosis, which may serve as pot...
nature.com
Please share - this year's #ListerPrize is open for applications for another month! 🔎 Read about what winning it mean to some of our former Fellows like Dr Stineke Van Houte here: lister-institute.org.uk/what-it-mean... 🙋 Find out more about how to apply: lister-institute.org.uk/how-to-apply/
⭐NAR Breakthrough!⭐ 🧬 Sun et al. just dropped a high-throughput method to track all #tRNA #modifications across cells & tissues using #massspec. Read the full article here: doi.org/10.1093/nar/... #NARBreakthrough #RNA #tRNA #epitranscriptomics #systemsbiology #therapeuticdiscovery.
tRNA modification profiling reveals epitranscriptome regulatory networks in Pseudomonas aeruginosa
Abstract. Transfer RNA (tRNA) modifications have emerged as critical post-transcriptional regulators of gene expression affecting diverse biological and di
doi.org
🧪Move over CUT&Tag, there’s a new #TranscriptionFactor mapping method in town. Our newly developed DynaTag is faster, cleaner, more sensitive than #ChIPseq, #CUT&RUN and #CUT&Tag. 🔗 Our @natcomms.nature.com paper: www.nature.com/articles/s41... 🧵Let’s break down what makes DynaTag so powerful (1/7)
Happy to share our latest preprint describing the first genome-wide mapping of G4s in T.Brucei, led by the amazing Ludovica Monti. We found that G4s accumulate in coding regions of the parasite, causing transcriptional perturbation upon treatment with G4-ligands. www.biorxiv.org/content/10.1...
Genome-wide mapping of DNA G-quadruplexes in Trypanosoma brucei chromatin reveals enrichment in coding regions
G-quadruplexes (G4s) are non-canonical DNA structures formed in guanine-rich sequences that are proposed to act as regulatory elements in trypanosomatid parasites, including Trypanosoma brucei, the ca...
biorxiv.org
BBC News - Babies made using three people's DNA are born free of hereditary disease www.bbc.com/news/article...
Babies from three people's DNA prevents heriditary disease
The method was pioneered by UK scientists to overcome devastating, sometimes fatal inherited diseases.
bbc.com
Congratulations to all the prize winners from the Nucleic Acids Forum 2025! An amazing selection of talks and posters to choose from! Thank you to our prize sponsors Chemgenes and RSC Chemical Biology! @rscchembio.rsc.org @mikeboothlab.bsky.social
📣NAR Breakthrough Article!📣 ✂️ Removal of a single tRNA^Gly gene copy in Staphylococcus aureus via CRISPR weakens the cell wall, biofilm formation and increases antibiotic susceptibility💊 📖 doi.org/10.1093/nar/... #Microbiology #CRISPR #tRNA #AntibioticResearch #BacterialGenetics
Outstanding work, well done Mike it was an amazing day!
Michael Booth@drmikebooth.bsky.social · last yr.It was a privilege to organise the 2025 RSC Nucleic Acids Forum at Burlington House last week - @rscnucleicacids.bsky.social! The NAF has been my favourite event every year, so it was amazing to run it myself! Full crowd, fantastic talks and posters, and a wonderful community 🧬❤️
Thank you for your constant support! @thelisterinstitute.bsky.social
The Lister Institute of Preventive Medicine@thelisterinstitute.bsky.social · last yr.Great paper from #ListerFellow Marco Di Antonio et al. G-quadruplex DNA appears to help ovarian cancer cells activate genes that shield them from chemotherapy. Drugs targeted to these structures re-sensitised the resistant cells to standard therapies. Super work @diantoniogroup.bsky.social 🫶
Very pleased to see that The Observer has written a piece to cover our recent work in Genome Biology applied to ovarian cancer chemoresistance. Link below 👇👇👇 @theobserveruk.bsky.social @imperialcollegeldn.bsky.social @imperialchemistry.bsky.social observer.co.uk/news/nationa...
observer.co.uk
Ready for super-G4s? We have identified clusters of G4s in intergenic regions that act as super-enhancers in ovarian cancer cells, hence the name super-G4! These are de novo super-enhancers that are not underpinned by canonical epigenetic marks, supporting the epigenetic role of G4s rdcu.be/evXtf
Starting off our NAF 2025 meeting with an introduction of the RSC Nucleic Acids Group's new chair, Marco Di Antonio! An exciting new era for our group begins! 🧬 @diantoniogroup.bsky.social
A big thank you to Mike Booth for organising this meeting! We have a great line-up for a very exciting day! Once again we would like to thank our sponsors for their support! @drmikebooth.bsky.social
Our final speaker of the day is Thomas Maher from Imperial College London, presenting his work on the “Interrogation of the nuclear G quadruplex interactome through SG4directed proximity labelling“
