Ishier Raote

@ishier.bsky.social

Institut Jacques Monod, Paris @ijmonod.bsky.social https://www.ijm.fr/raote-lab/ Collagen secretion, membrane trafficking Formerly @crg.eu

Very happy to see this #MechanoGolgi story out (and in full open access, thanks to @upf.edu). Thanks a lot to everyone who contributed and helped make this possible, and, hopefully, more to come! rupress.org/jcb/article/...

Mechanical forces stimulate Golgi export

Bhaskar Naidu and Vera Lillo et al. show that extracellular mechanical forces reciprocally regulate Golgi function. By linking cell adhesion and spreading,

rupress.org

Felix Campelo@felixmendu.bsky.social · 11mo ago

🧵 I've been meaning to write a #Skytorial on our recently posted prepring in which we show evidence that the Golgi 🥞 is a mechanoresponsive organelle. Extracellular mechanical forces also tune Golgi export capacity! 👉 www.biorxiv.org/content/10.1...

Save the date! Club Exocytose-Endocytose half-day scientific meeting is planned 📅 1 Dec 2026, 2 pm 📍 Centre Broca Nouvelle-Aquitaine, Bordeaux Neurocampus 🎤 ~8 talks 💻 Hybrid: in person or online Registration & abstract submission open in September. Stay tuned !!

Latest work from the team driven by our fantastic post-doc Maribel Arjona. Using cytoplasm extract fractions and active rheology, we adress how endomembranes, that pack the cell interior, influence the mechanics of the cytoplasm! @ijmonod.bsky.social @cnrsbiologie.bsky.social

bioRxiv Biophysics@biorxiv-biophys.bsky.social · 2w ago

A Composite Endomembrane Suspension Governs Cytoplasm Rheology https://www.biorxiv.org/content/10.64898/2026.07.20.739612v1

1/ Mitochondrial Na⁺ links metabolism, Ca2+ signaling and disease. We know how it gets in, how it gets out, and proteins that use it. But: we've never actually seen Na⁺ in single mitochondria in live cells. We started with an unusual observation, went down a rabbit hole & found some cool biology .

A mitochondrion showing Ca2+ entering through the MCU, exchanged for Na+ by NCLX, Complex I acting as a Na+/H+ exchanger, and various transporters that use Na+ to move their substrates in and out of the mitochondria

Happy to share our review of seipin as a lipid rheostat, not just a #lipiddroplet biogenesis factor. Its flexible structure, with cofactors and ligands, integrates metabolic cues at organelle contacts, coordinating lipid storage, membrane synthesis, and signaling. rupress.org/jcb/article/...

Seipin: A central lipid rheostat

Thiam and Carpentier review seipin as a conformationally dynamic lipid rheostat that steers lipid fate and preserves cellular metabolic balance.

rupress.org