Interested in how age related immune dysfunction might impact stroke risk and outcomes? Check out our systematic review led by Vanda Wen Teng Ho at the National University of Singapore www.frontiersin.org/journals/agi...

Frontiers | Immunosenescence and its impact on ischemic stroke risk and outcomes in older adults: a systematic review

BackgroundAge is a major risk factor for ischemic stroke (IS), with immunosenescence–age-related immune system dysfunction - contributing to worse outcomes. ...

frontiersin.org

Nice summary of our recent publications in the articles below

Institute for Regeneration and Repair@edinuni-irr.bsky.social · 8mo ago

Two new papers from the McCulloch lab reveal how the body changes after experiencing a stroke. 1. Stroke and “fight-or-flight” response weakens the immune system > edin.ac/4a166dD 2. Long term changes to the intestinal microbiome seen after stroke > edin.ac/4jR2LBl

We have a second paper to share this week, this time investigating the gut-brain axis in stroke. Here we show that stroke is associated with persistent gut structural and microbiome changes, however these changes are distinct in acute and chronic recovery. journals.sagepub.com/doi/10.1177/...

Dynamic changes to the intestinal environment occur throughout recovery from experimental ischaemic stroke - Rachel M L Martin, Isobel C Mouat, Robert J Whelan, Lizi M Hegarty, Lizzie F R Blunt, Chris...

Stroke survivors can experience a plethora of complications throughout their recovery that impair quality of life and impact neurological outcomes. Intestinal d...

journals.sagepub.com

Great team-work behind our paper just published on stroke-induced immune cell changes, involving groups across @edinunineuro.bsky.social @edinuni-irr.bsky.social @ukdri.ac.uk @lydiabeckeriii.bsky.social. A pandemic in midst of study not anticipated at outset!

Dr Laura McCulloch@dr-l-mcculloch.bsky.social · 8mo ago

I’m excited to start 2026 with our new collaborative research paper examining circulating B cell populations in acute ischemic stroke patients, which is particularly exciting as we see translation of our previous data from animal models into patients. www.sciencedirect.com/science/arti...

I’m excited to start 2026 with our new collaborative research paper examining circulating B cell populations in acute ischemic stroke patients, which is particularly exciting as we see translation of our previous data from animal models into patients. www.sciencedirect.com/science/arti...

Acute ischaemic stroke alters the composition and function of circulating B cells

Distinct B cell populations are found in circulation, including those with innate-like properties, that have varied functions in pathogen protection, …

sciencedirect.com

We have a further exciting PhD opportunity in the lab investigating the impact of systemic infection on the recovering brain after stroke and its link to small vessel disease and cognitive decline. Details in the link below www.findaphd.com/phds/project...

VIDA DTC - Understanding the impact of post-stroke infection on neuroinflammation and small vessel disease in stroke recovery at University of Edinburgh on FindAPhD.com

PhD Project - VIDA DTC - Understanding the impact of post-stroke infection on neuroinflammation and small vessel disease in stroke recovery at University of Edinburgh, listed on FindAPhD.com

findaphd.com

🧠🛡️ Don’t miss Neuroimmunology Across the Body, exploring brain–immune–nerve crosstalk in infection, pain and gut–brain health. Proudly sponsored by the UK GIBA Network. #Neuroimmunology #BSI2025

Not long to go until #BSI25 For neuroimmunology enthusiasts, please come to our double session "Neuroimmunology across the body" on Wed 3rd jointly hosted by the Neuroimmunology Affinity Group and Wessex Immunology Group

New paper out from the lab, led by Maddy Hurry. We investigate how stroke leads to peripheral complications in the gut through dysregulation of IgA mediated host-commensal crosstalk. @lydiabeckeriii.bsky.social @diiirm.bsky.social www.sciencedirect.com/science/arti...

Cerebral ischaemic stroke results in altered mucosal antibody responses and host-commensal microbiota interactions

Stroke is a devastating neurological event with a high risk of mortality that results in long-term sequalae that extend beyond the central nervous sys…

sciencedirect.com

I am pleased to offer another PhD opportunity supervised by myself and @joyedwardshicks.bsky.social Here we will investigate how neural signals regulate adaptive immune responses www.findaphd.com/phds/project...

EASTBIO - Investigating how neural signalling regulates adaptive immune responses at University of Edinburgh on FindAPhD.com

PhD Project - EASTBIO - Investigating how neural signalling regulates adaptive immune responses at University of Edinburgh, listed on FindAPhD.com

findaphd.com

We are looking for a PhD. student to work with us on our investigation into immune suppression and infection vulnerability after stroke. This project will focus on the lung immune environment and therapeutic interventions to improve infection clearance. www.findaphd.com/phds/project...

Understanding pneumonia vulnerability in stroke recovery at University of Edinburgh on FindAPhD.com

PhD Project - Understanding pneumonia vulnerability in stroke recovery at University of Edinburgh, listed on FindAPhD.com

findaphd.com

Join the Dyer Lab (Dr @douglaspdyer.bsky.social) as a Research Associate in Neuro-Immunology & Extracellular Matrix Biology (ImmunoMatrix). 🔬 Focus: chemokines, glycocalyx & inflammatory disease 📍 Cutting-edge biochem, biophysics & in vivo biology Apply now 👉 shorturl.at/jEQ6G

🚨 The Menon lab is hiring a postdoc! Interested in mucosal immunology? Come join our team to study lung-infiltrating B cell dynamics in COPD & other chronic lung diseases @ukri.org @lydiabeckeriii.bsky.social Please help spread the word #ImmunoSky www.jobs.manchester.ac.uk/Job/JobDetai...

Research Associate in Mucosal Immunology :Manchester

jobs.manchester.ac.uk

Explore new research on #Neuroimmunology & #Neurodegeneration, incl. macular degeneration, the role of #microglia, β-amyloid transport, CNS #autoimmunity, and the sympathetic control of cancer progression 👉 rupress.org/jem/collecti... #ksneuroimmune25 #ksneurodegen25 @keystonesymposia.bsky.social‬

Please join us for the summer EIG mini symposium on Tuesday 17th of June. The session starts at 13:30 in @edinuni-irr.bsky.social IRR South seminar room 1.05 with talks by Prof Simon Graham, Dr Kate Sutton and Prof Christoph Scheiermann. See you there!

Now online! Macrophages direct location-dependent recall of B cell memory to vaccination

Macrophages direct location-dependent recall of B cell memory to vaccination

Subcapsular sinus macrophages in the draining lymph node help retain resident memory B cells in the subcapsular niche and promote their re-entry into secondary germinal centers. Boosting vaccines in the same arm leads to more rapid secretion of broadly neutralizing antibodies.

dlvr.it

🚨New preprint alert 🚨 www.biorxiv.org/content/10.1... Delighted to share our recent study looking at chronic changes to the intestine and intestinal microbiome after stroke

The spring EIG session is coming this Thursday on 1st of May. Please join us from 13:30 in @edinuni-irr.bsky.social IRR South seminar room 1.05 for fantastic talks by Dr. Elizabeth Mann, Dr. Tovah Shaw and Prof. Hamida Hammad. See you there!

So excited to share our first neuro focused paper from the lab, we show that CXCL4 (PF4) is transported into the brain by proteoglycans within the endothelial glycocalyx and that GAG binding also mediates the pro neurogenesis effects of CXCL4. www.biorxiv.org/content/10.1...

blog.sciencemuseum.org.uk/the-most-com...

The most complete map of a brain is unveiled today - Science Museum Blog

Roger Highfield, Science Director, reports on the latest milestone in what is billed as the most complicated neuroscience experiment ever.

blog.sciencemuseum.org.uk

'The results show that mitochondria, which generate the energy that powers cells, differ in type and density in different parts of the brain. For example, the evolutionarily oldest brain regions have a lower density of mitochondria than newer regions.' www.nature.com/articles/d41...

First map of human brain mitochondria is ‘groundbreaking’ achievement

Hundreds of cubes of human brain tissue help scientists to chart the energy-making capabilities of various brain regions.

nature.com

Heart-brain-spleen axis that induces adaptive cardiac remodeling in response to pressure overload www.cell.com/immunity/ful... preview @cp-immunity.bsky.social www.cell.com/immunity/ful...

Organ-specific sympathetic innervation defines visceral functions www.nature.com/articles/s41...

Organ-specific sympathetic innervation defines visceral functions - Nature

Multi-modal transcriptomic analyses of the sympathetic nervous system reveal organ-specific neural innervation and modular regulation of visceral functions.

nature.com

Stoler-Barak, @zivshulman.bsky.social et al. show that SMARCA5-mediated #chromatin remodeling is required for germinal center formation rupress.org/jem/article/... 📘 In Multifaceted B Cell Functions & Dysfunctions: rupress.org/jem/collecti... #KSBCells25

Our new collection highlights recent advances in B lymphocyte biology from homeostasis to inflammation & dysfunction leading to lymphoma development. Read new research accompanying @keystonesymposia.bsky.social on Multifaceted B Cell Functions & Dysfunctions: https://buff.ly/3CX1Y0O #KSBCells25

🚨 We have TWO exciting open positions in our lab! 🚨 We are looking for talented, highly motivated, and collaborative individuals to join our dynamic team as: 🔬 Research Assistant www.kennedy.ox.ac.uk/jobs/researc... 💻 Bioinformatics Postdoc www.kennedy.ox.ac.uk/jobs/bioinfo... 📢 Please share!

Research Assistant (177885)

We are looking for a Research Assistant with a background in immunology/neurobiology to join the interdisciplinary laboratory of Dr Fränze Progatzky at the Kennedy Institute.

kennedy.ox.ac.uk

Our new publication on BCR sequencing in ME/CFS, adding to the evidence of an increased usage of IGHV3-30. Much more immunological research is needed to understand the many lines of evidence indicating immune-mediated or autoimmune components to the disease. www.frontiersin.org/journals/imm...

Frontiers | Deep sequencing of BCR heavy chain repertoires in myalgic encephalomyelitis/chronic fatigue syndrome

frontiersin.org

First Post on blue-sky. We are hiring! Post-doctoral position available in the neuroimmunology of stroke. Please check out link below and share elxw.fa.em3.oraclecloud.com/hcmUI/Candid...