Dylan Thompson

@drdylanthompson.bsky.social

Professor at the University of Bath, UK https://researchportal.bath.ac.uk/en/persons/dylan-thompson. Co-Director of the Centre for Nutrition, Exercise and Metabolism https://www.bath.ac.uk/research-centres/centre-for-nutrition-exercise-and-metabolism/

Exercise without Weight Loss Prevents Seasonal Decline in Vitamin D Metabolites: The VitaDEx Randomized Controlled Trial

Exercise without Weight Loss Prevents Seasonal Decline in Vitamin D Metabolites: The VitaDEx Randomized Controlled Trial

In people with overweight or obesity, regular exercise even without weight loss or vitamin D supplementation completely prevents the usual winter decline in the vitamin D metabolite that maintains health at a cellular level, 1,25(OH) 2 D 3 , and ameliorates the decline in the vitamin D status marker 25(OH)D. Abstract Many adults become vitamin D deficient or insufficient during winter at northerly latitudes when cutaneous vitamin D synthesis does not occur. Vitamin D accumulates in adipose tissue and people with overweight or obesity are more likely to have low systemic vitamin D. This randomized controlled trial demonstrates that regular exercise completely maintains serum concentrations of the active vitamin D metabolite 1,25(OH) 2 D 3 over winter and may ameliorate the decline in 25(OH)D status in overweight men and women, even without weight loss. The binding of 1,25(OH) 2 D 3 to the vitamin D receptor mediates the crucial role for vitamin D in the healthy function of multiple organ systems and vitamin D supplementation does not impact circulating 1,25(OH) 2 D 3 . Thus, the VitaDEx study provides causal evidence that exercise plays an important role in vitamin D metabolism that is distinct from the effects of oral supplementation.

advanced.onlinelibrary.wiley.com

This piece is based on our paper, sciencedirect.com/science/arti..., which is well worth a read to see how statistics informs physiological inferences. The study of a very important physiological hypothesis being compromised by correlating X with Y-X and getting excited about a -ve slope.

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Dylan Thompson@drdylanthompson.bsky.social · 2y ago

Are you being bombarded with messages telling you that physical activity won’t increase energy expenditure because it is constrained? Here is our little piece on this topic for The Conversation. @uk.theconversation.com theconversation.com/exercise-doe...