Excited to share that my abstract was accepted to #ESID2026 in #Maastricht! Looking forward to sharing my research, exchanging ideas, and learning about the latest developments in #IEI. Join us before 13 July to enjoy the best rates! 👉 invt.io/1bxbenkmqdq

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In a new study from Tan, Kergaravat, @petterbrodin.bsky.social et al., longitudinal profiling of 136 newborns shows thymic output peaks at 3–4 mo, correlating with plasma RANKL, lymphotoxin-α, and the TCRD variant rs2204985. rupress.org/jhi/article/...

Excited to share our work showing that patients with inborn errors of immunity generate immune memory after COVID-19 vaccination, even when neutralizing antibodies are absent. This challenges how we measure vaccine success, & the need to look beyond antibodies. authors.elsevier.com/a/1mwz8Ks2xP...

Excited to share our work showing that patients with inborn errors of immunity generate immune memory after COVID-19 vaccination, even when neutralizing antibodies are absent. This challenges how we measure vaccine success, & the need to look beyond antibodies. authors.elsevier.com/a/1mwz8Ks2xP...

Congrats Todd & team @bruskolab.bsky.social Large-scale TCR repertoire profiling from peripheral blood reveals type 1 diabetes signatures linked to high-risk HLA alleles www.science.org/doi/10.1126/...

Single cell mapping identifies a distinct platelet-phenotype in psoriatic type III inflammation @natcomms.nature.com www.nature.com/articles/s41...

One mechanism is Ddx3x support of Brwd1 expression at pre B cell stage and support of efficient cell cycle arrest as well as light chain rearrangement (resulting in skewed kappa/lambda usage)

We are all mosaics: vast genetic diversity found between cells in a single person @nature.com www.nature.com/articles/d41... @biorxivpreprint.bsky.social ⁦@mayoclinic.org @harvardmed.bsky.social @timcoorens.bsky.social @emblebi.bsky.social www.biorxiv.org/content/10.1...

Single-Cell Multi-Omics Dissects Transcript Isoform and Immune Repertoire Dynamics in Human Immunosenescence https://www.biorxiv.org/content/10.1101/2025.11.21.689731v1

A PIK3delta inhibitor for ALPS: Leniolisib reduced lymphoproliferative disease in murine autoimmune lymphoproliferative syndrome url: rupress.org/jhi/article/...

Data-driven forecasting of Flu, RSV, and COVID-19 related outcomes in the United States and Canada via Hankel dynamic mode decomposition https://www.medrxiv.org/content/10.1101/2025.11.12.25339917v1

Predicting long-term waning of anti-spike antibody-dependent protection against COVID-19 across diverse SARS-CoV-2 immune histories https://www.medrxiv.org/content/10.1101/2025.11.14.25340279v1

Circulating biomarkers of bronchoalveolar injury help predict the need for mechanical ventilation in patients with moderate to severe COVID-19 pneumonia: a prospective cohort study https://www.medrxiv.org/content/10.1101/2025.11.16.25340358v1

@jengommerman.bsky.social lab investigate an animal model of progressive #MultipleSclerosis & uncover a population of anti-CD20–resistant dural B cells that remain in the brain parenchyma at disease remission rupress.org/jem/article/... 📘 In #Neuroscience 2025: rupress.org/jem/collecti... #SfN25

🗨️ Just published in Nature Biotechnology: Our CellWhisperer AI enables chat-based analysis of single-cell sequencing data. You can talk to your cells & figure out the biology without writing any computer code. Paper here: www.nature.com/articles/s41.... Annotated walkthrough in a thread below (1/11)

Proud to share our new preprint revealing how patients with inborn errors of immunity respond to 3 doses of COVID-19 vaccination. A fantastic collaboration between clinicians & scientists. Monash University, Alfred Health, Monash Health, Burnet Institute, BD, Erasmus MC medrxiv.org/cgi/content/...

Third dose COVID-19 vaccination elicits immune memory in patients with inborn errors of immunity even in absence of neutralizing antibodies

Background: Immunocompromised people, including those with Inborn Errors of Immunity (IEI), are at increased risk of severe disease from viral infections. Therefore, regular booster vaccinations are r...

medrxiv.org

Active learning framework leveraging transcriptomics identifies modulators of disease phenotypes @science.org @shaleklab.bsky.social www.science.org/doi/10.1126/...

I’m excited to share our newly published paper. Only the second report of Spleen Tyrosine Kinase (SYK) gain-of-function. We detail the clinical, immunological, and genetic features of an adult with primary immunodeficiency and autoinflammation in the Journal of Clinical Immunology: 🔗 rdcu.be/eLWFr

Proud to be talking at this webinar on the 8th of October alongside Ig therapy manufacturers, patients receiving therapy, clinicians and SCIg nurses. #patientawareness

AusPIPS Inc. @auspips.bsky.social · 11mo ago

Join us on 8th October in our webinar with Immune Deficiency Foundation of Australia (IDFA). Our Vice President @dremmye.bsky.social talk about what Ig is, and how this treatment aims to protect from infection. Alongside presentations on the benefits of Ig therapy! Register here: lnkd.in/dwUj3Mec

New content online:

Genetic regulation of cell type–specific chromatin accessibility shapes immune function and disease risk @medrxivpreprint.bsky.social @anglixue.bsky.social @drjosephpowell.bsky.social www.medrxiv.org/content/10.1...

Shared Immune and Epigenetic Pathways in Systemic Lupus Erythematosus and Melanoma Immunotherapy: A Cross-Disease Analysis with Prognostic and Therapeutic Implications https://www.biorxiv.org/content/10.1101/2025.08.19.671053v1

From lab bench to Parliament House, a few weeks ago, I was proud to bring the voices of patient advocacy and rare disease research to advocate for equitable and fair access to vaccination and blood products. With this dual lens, I added evidence-based insights to strengthen the case for change.

Amazing new paper from @krishaurum.bsky.social and colleagues, designing novel pMHC-binders (synthetic TCRs) in silico: www.science.org/doi/10.1126/...

De novo-designed pMHC binders facilitate T cell–mediated cytotoxicity toward cancer cells

The recognition of intracellular antigens by CD8+ T cells through T cell receptors (TCRs) is central for adaptive immunity against infections and cancer. However, the identification of TCRs from patie...

science.org

Scalable screening of ternary-code DNA methylation dynamics associated with human traits www.cell.com/cell-genomic...

Differences in immune cell profiles around the time of islet autoimmunity seroconversion in children with and without type 1 diabetes https://www.biorxiv.org/content/10.1101/2025.06.23.661117v1

An excellent preprint offering valuable insights into the impact of CMV infection on the immune system. Three insights are important as CMV is a herpesvirus, to which over 70% of the population has been exposed.

bioRxiv Immunology@biorxiv-immuno.bsky.social · last yr.

CMV reshapes lymphoid immunity in aging: a single-cell atlas with predictive modeling https://www.biorxiv.org/content/10.1101/2025.06.24.661167v1

Topical JAK inhibitor for refractory skin #inflammation in STAT1 GOF. New report from Valentina Guarnieri, Tiphaine Arlabosse, Claire Booth, and Gabriela Petrof @greatormondst.bsky.social: rupress.org/jhi/article/... #Therapeutics #InbornErrorsOfImmunity

So fabulous to see this paper out! Prof Lucy Wedderburn is a close collaborator of many researchers in our dept and this paper makes an important contribution to continued efforts to understand better ways to predict treatment response in patients with autoimmune conditions 🧬 read more below 👇

UCL News@uclnews.bsky.social · last yr.

Researchers at @ucl.ac.uk's Great Ormond Street Institute for Child Health and @greatormondst.bsky.social including Professor Lucy Wedderburn have identified a set of genes which could help predict children's response to an arthritis treatment @uclpophealthsci.bsky.social

Proud to be a recipient of a seed grant from the Victorian Critical Vaccinees Collection, to investigate memory B cells in elderly individuals receiving the COVID-19 vaccine, and finding parallels with responses in immunocompromised lnkd.in/g2FxQX5q @MonashSTM @ErasmusMC