A right-handed helix in the Cambridge skyline.

My first post here - so let‘s start with a bang! Last week the major part of my MD-PhD work at the @biomedizin.unibas.ch was published @emboreports.org. I want to thank my supervisors and amazing collaborators for their efforts and contributions to this story. So let‘s talk about what we found!

A conserved VPS34-PIKfyve-TRPML1-myosin II axis regulates the speed of amoeboid cell migration - EMBO Reports

Amoeboid cell migration is key to efficient T cell immunity. Spatial polarization of organelles within cells, including endo-lysosomes, is a prerequisite of migration. However, how ultrastructural pol...

link.springer.com

Not just another kinase: I've edited a special issue on the many roles for PI3Kδ in adaptive immunity for the Journal of Immunology. Many thanks to Bart Vanhaesebroeck, Pam Schwartzberg, Elissa Deenick and colleagues for their excellent and timely contributions. academic.oup.com/jimmunol/iss...

Volume 215 Issue 5 | The Journal of Immunology | Oxford Academic

The JI publishes peer-reviewed manuscripts describing novel findings in all areas of experimental immunology, including both basic and clinical studies.

academic.oup.com

Editorial @jimmunol.bsky.social @klausokken.bsky.social Not just another kinase: the many roles of PI3K-δ in adaptive immunity academic.oup.com/jimmunol/art...

Not just another kinase: the many roles of PI3K-δ in adaptive immunity

PI3K transmit signals from receptors by phosphorylating phosphoinositides on the inner leaflet of the plasma membrane. PI3K enzymatic activity was first de

academic.oup.com

Time to retire? www.nature.com/articles/s41... "We present The AI Scientist, which creates research ideas, writes code, runs experiments, plots and analyses data, writes the entire scientific manuscript, and performs its own peer review".

Towards end-to-end automation of AI research - Nature

An artificial intelligence system can produce research papers with minimal human involvement, even passing the first round of peer review for the workshop of a main machine learning conference.

nature.com

Our latest review is out, a comprehensive synthesis of #tissue #Tregs. It has been a decade since @annualreviews.bsky.social #immunology last reviewed #TissueTregs, and there have been enormous advances and conceptual leaps forward in the field www.annualreviews.org/content/jour...

Tissue Regulatory T Cells

FOXP3+ regulatory T cells (Tregs) have well-defined roles in limiting systemic immune responses against diverse stimuli. However, the observation that a subset of Tregs also enter nonlymphoid tissues,...

annualreviews.org

These are not a ranking lists we should be topping... royalsociety.org/-/media/poli...

The Royal Society@royalsociety.org · 10mo ago

Today we have published a new analysis of UK immigration costs, comparing the 2025 costs of skilled worker, researcher and student visas in the UK and 17 other leading science nations. This updates previous analysis from 2019, 2021 and 2024: royalsociety.org/news-resourc...

Wonderful to see the seminal discoveries of Shimon Sakaguchi, Mary E. Brunkow & Fred Ramsdell recognised with the Nobel Prize. From Sakaguchi’s discovery of Treg cells to the identification of Foxp3, their research opened a new chapter in immunology, viewed from the prism of dominant tolerance.

A small primer on the #NobelPrize awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi today. This prize was for combining two separate fields of immunology research - genetic research on IPEX and immunology research of regulatory T cells (#Tregs), with enormous impact on biology/medicine

Nobel prize for Tregs! www.nobelprize.org/prizes/medic...

Nobel Prize in Physiology or Medicine 2025

The Nobel Prize in Physiology or Medicine 2025 was awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi “for their discoveries concerning peripheral immune tolerance.”

nobelprize.org

Great to welcome former PhD student, now Assistant Professor @krishaurum.bsky.social of the DTU back to the Department of Pathology. Excellent presentation on TIL TCRs, peptide-MHC complexes and his recent paper on AI-designed pMHC binders (artificial TCRs).

Listen to James Edgar @campathology.bsky.social discuss cosmetic use of exosomes on BBC Radio 4 Inside Health: www.bbc.co.uk/sounds/play/... (Spoiler alert: he does not approve).

Inside Health - Exosomes: Is cosmetics' biggest trend a health risk? - BBC Sounds

James finds out why there are fears over new skincare products, plus physio goes digital.

bbc.co.uk

Amazing new paper from @krishaurum.bsky.social and colleagues, designing novel pMHC-binders (synthetic TCRs) in silico: www.science.org/doi/10.1126/...

De novo-designed pMHC binders facilitate T cell–mediated cytotoxicity toward cancer cells

The recognition of intracellular antigens by CD8+ T cells through T cell receptors (TCRs) is central for adaptive immunity against infections and cancer. However, the identification of TCRs from patie...

science.org

We're recruiting a postdoc to join my lab at @oncology.ox.ac.uk & @oxcio.bsky.social to understand immune regulation in cancer and develop new approaches for cancer prevention and metastasis. Deadline: 11 August 2025 my.corehr.com/pls/uoxrecru... Lab info: www.oncology.ox.ac.uk/team/jie-yang

I've been incredibly lucky to be supported by the @erc.europa.eu with a Start, Consolidator and now Advanced grant! Each of these awards enabled 'blue skies' research into the immune system, as well as resulting in direct translational impact on patients and via commercialisation. 🥰

European Research Council (ERC)@erc.europa.eu · last yr.

📣 Good news: 281 top researchers have just won ERC Advanced Grants! The new funding, worth nearly €721 million, is part of the 🇪🇺 EU’s #HorizonEurope programme. Find out more 👉 europa.eu/!JYKxkD #ERCAdG #FrontierResearch @ec.europa.eu

I am delighted to see that Len Stephens, my colleague and PI3K pioneer, has been awarded the 2026 Biochemical Society Morton Lecture for outstanding contributions to lipid biochemistry! www.babraham.ac.uk/news/2025/04...

New research article from the lab led by the amazing @amydashwood.bsky.social ! In collaboration with @vib-switch-lab.bsky.social @cbdresearch.bsky.social we engineered variants of #IL2 designed for therapeutic use. 1/11 www.sciencedirect.com/science/arti...

Directed disruption of IL2 aggregation and receptor binding sites produces designer biologics with enhanced specificity and improved production capacity

The pleotropic nature of interleukin-2 (IL2) has allowed it to be used as both a pro-inflammatory and anti-inflammatory therapeutic agent, through pro…

sciencedirect.com

Last few days to apply for this:

Brian Ferguson@viropractor.bsky.social · 2y ago

There is a Postdoc job available in my lab to study fundamental mechanisms of antiviral immunity, specifically in the context of viral nucleic acid sensing. Please take a look here and contact me if interested: #immunosky #virology 🧪 www.jobs.cam.ac.uk/job/50254/

Thrilled to share new work led by @jieyang437.bsky.social in the lab published today in @Nature. We find that Aspirin prevents metastasis by releasing T cells from immune suppression by platelet TXA2. @Cambridge_Uni @CRUKCamCentre rdcu.be/eci1U

Brilliant new paper from Jie Yang @jieyang437.bsky.social and Rahul Roychoudhuri @roychoudhurilab.bsky.social linking aspirin to immune-mediated prevention of cancer metastasis. www.nature.com/articles/s41...

Aspirin prevents metastasis by limiting platelet TXA2 suppression of T cell immunity - Nature

Inhibition of cyclooxygenase 1 releases T cells from immunosuppression by platelet-derived thromboxane A2, thereby enhancing the immune response against metastasis.

nature.com

📢 Calling all Signallers! Join us for this celebratory smorgasbord of signalling research on 1-2 May with sessions on #proteostasis, #PI3K, #autophagy, #redox biology and #nuclear signalling. 🧪 Latest Institute research with special guests ⤵️ www.eventbrite.co.uk/e/cellular-s...

Cellular signals for health & disease

A symposium marking the contributions of Len Stephens and Phillip Hawkins

eventbrite.co.uk

📢 New position! We are recruiting an Associate Professor / Professor of Infection and/or Immunity to join our innovative research community! Find out more about the position and apply: https://buff.ly/40m1udb

Many congratulations to Prof Ashley Moffett on this honour! This is in recognition of her long and impactful research on the genetics and immunology of maternal and foetal health, especially as related to pre-eclampsia and and the role of NK cells in the development and function of the placenta.

Pathology at Cambridge@campathology.bsky.social · 2y ago

Our very own Professor Ashley Moffett of Reproductive Immunology was awarded the prestigious CMP for Women’s Reproductive Health. The foremost international authority on the immunology of human reproduction, her work has helped explain high rates of pre-eclampsia and maternal mortality in Africa.

A very rare position for an immunology professorship at Cambridge. Something to think about! www.jobs.cam.ac.uk/job/49381/

I've added a PI3K starter pack. Please help me populate it by replying to this post. #PI3K #PTEN #AKT #mTOR #FOXO go.bsky.app/7p2g5eN

A starter pack for PhD students and Postdocs in Immunology to connect 🔽 Drop a 🧬 and I'll add you to the list. Let's build the upcoming immuno community! #ImmunoSky 🧪 go.bsky.app/RABVXY4

Professorship in Immunity and Infection at the University of Cambridge: www.jobs.cam.ac.uk/job/49381/ Check out the cross-departmental infection and immunity theme for the grand challenges we want to address: www.bio.cam.ac.uk/research/inf... Application deadline: Jan 26th, 2025.

"The FDA has approved Genentech’s inavolisib (Itovebi) in combination with the CDK4/6 inhibitor palbociclib and the oestrogen-receptor antagonist fulvestrant for endocrine-resistant, PIK3CA-mutated, hormone receptor-positive, HER2-negative breast cancer." #PI3K www.nature.com/articles/d41...

Our latest paper reveals an intriguing and essential role for the class III #PI3K VPS34 in Treg homeostasis and function. Selective deletion of VPS34 in Treg led to a scurfy-like phenotype, suggesting an essential role for VPS34 in Treg-suppression. doi.org/10.3389/fimm... #immunosky

The freshly cooked video summarizing the Art project developed in the frame of our PIPgen MSCA DN: “PIPgenerating ART: Where Art meet Science “. A collaborative activitys between our students and the Cambridge School of Visual Performing Arts. www.youtube.com/watch?v=tQxA...

PIPgenerating ART: Where Art meet Science

YouTube video by PIPgen

youtube.com