I had the pleasure of speaking with the Doctor's Kitchen (not on BlueSky) about mould. Was a great conversation and as always the simple questions are the hardiest to answer. You can watch it on YouTube if you're interested: youtu.be/n3XSUDrKT54?...

Why mould harms your health and how to protect yourself with Dr Peter Cook PhD

YouTube video by The Doctor's Kitchen

youtu.be

Its my great pleasure to say the latest paper from our group is now out: www.mucosalimmunology.org/article/S193... Check it out! We found that immune cell activation in the sputum identifies severe asthma patients. Massive thanks to the patients for agreeing to give sputum and blood samples.

Activation status of airway immune cells is a defining feature of severe asthma, regardless of fungal sensitisation

Global estimates of asthma prevalence are rising, with an estimated 262 million affected individuals in 2019.1 Purported reasons for this rapid rise include urbanisation of lower- and middle-income co...

mucosalimmunology.org

Check out our latest preprint, tracking fungal spores we were able to make some fascinating insights on how dendritic cells cause #fungal allergy. #immunosky. Huge thanks to our awesome collaborators who helped with this study! www.biorxiv.org/content/10.1...

Mgl2+ cDC2 triggering of fungal allergic inflammation depends on a spore induced glycolytic shift fuelled by local availability of glucose

Fungal spores are a major cause of severe asthmatic disease. However, the precise events that cause individuals to become sensitised to spores are poorly understood. Mgl2+ type 2 conventional dendriti...

biorxiv.org

Thanks to new funding from @wellcometrust.bsky.social we will soon be advertising two postdoc positions! Interested? Please get in touch in the first instance and I'll provide more info on the projects. You can also learn more on our lab website www.theradlab.co.uk #immunosky 🧪

After a period of silence, delighted to share our latest work has come out as a pre print. Check it out. Huge thanks to the amazing efforts of co-authors and most importantly the generosity of the patients in providing samples. www.medrxiv.org/content/10.1...

Activation status of immune cells in the airway is a defining feature of severe fungal asthma.

Airborne fungi are potent inducers of respiratory disease and cause the debilitating conditions severe asthma with fungal sensitisation (SAFS) and allergic bronchopulmonary aspergillosis (ABPA). Howev...

medrxiv.org

The past several weeks have taken a toll on all of us. We wrote this before the thick fog fell over science, out now, highlighting the exciting collective progress in the area of #microbiota and #IBD. Hoping reason prevails—for the sake of all and the collective progress of #science

Nature Reviews Microbiology@natrevmicro.nature.com · last yr.

New online! Microbiota in inflammatory bowel disease: mechanisms of disease and therapeutic opportunities

Excited to see this finally out!! We found IL-2 made by CD301b+ DCs critical for the Th2 fate decision of CD4T cells and skewing them away from the Tfh fate. They also seem to use their own CD25 to direct IL-2 to the cognate clone. www.nature.com/articles/s41...

CD301b+ dendritic cell-derived IL-2 dictates CD4+ T helper cell differentiation - Nature Communications

A subset of migratory type 2 conventional dendritic cells marked by CD301b expression (CD301b+DC), are required specifically for the development of Th2 cells. Here authors show that at the mechanistic...

nature.com

Out today - a new role for MAIT cells. We've shown MAIT cells are antibacterial; antiviral; and promote tissue repair. In this paper from our group we show MAIT cells are recruited and activated to protect tissues in sterile lung injury, and potentially in IPF - enjoy! doi.org/10.1016/j.ce...

*PhD project available funded by BBSRC WoH DLP,*. Are you interested in viral and fungal immunity? Keen to use learn the latest cutting edge technologies to address this working with partners at UKHSA? If yes then please reach out. Further details at: www.surrey.ac.uk/bbsrc-wessex...

Completely agree @profandrewmac.bsky.social! A pleasure to work with wonderful colleagues at several institutions including @mrccmm.bsky.social, @lydiabeckeriii.bsky.social and @uoe-eid.bsky.social. Fungi are major causes of asthma but why our immune cells do this is poorly understood.

Andrew S. MacDonald @profandrewmac.bsky.social · 2y ago

Delighted to see our study on #DendriticCell control of #fungal #allergic airway #inflammation finally out in the wild! Spearheaded by @drpetercook.bsky.social, with so many fantastic collaborators - thanks to all! #ImmunoSky 🧪 rdcu.be/d68MU @lydiabeckeriii.bsky.social @edinburgh-uni.bsky.social

Maternal type 2 immunity promotes a microchimeric transfer of systemic type 2 immunity to offspring. https://www.biorxiv.org/content/10.1101/2025.01.03.631175v1

🌟 Join #RTI2025 in Glasgow, Feb 3-5, 2025! Prof. Cilloniz will dive into CAP & Pneumococcal Disease: • Evolving CAP trends • Streptococcus pneumoniae & viruses • Vaccination strategies 🎁 30% discount: use RTIXMAS25 (first 20 only) 👉 rti-forum.org/2025 #Vaccination #CAP #RespiratoryTractInfections

So chuffed with how many people were in the room for our Exeter Respiratory Research meeting last week!! Ready for an exciting set of talks in the New Year 🫁🤙 Special thanks to our theme reps Adilia (@adilia12.bsky.social), Michael, Chris and Owen for presenting this time around.

Join the Sutherland Lab in Aberdeen! We have a research fellow opening to explore IL-13 regulation of hyaluronan extracellular matrices drug lung injury, repair and chronic pathology with funding from @wellcometrust.bsky.social www.abdn.ac.uk/research/job...

A pleasure to congratulate Dr Daniel Conn (not on here yet) from the group who successfully passed his PhD viva today. What a fanatastic journey it’s been @mrccmm.bsky.social Huge thanks to the awesome examiners @billhorsnell.bsky.social, @lloydlab.bsky.social and Mark Ramsdale.

First 🦋 post (great to join everyone here) about our paper that's been published in JACI: www.jacionline.org/article/S009... Check it out if you have ever wondered how fungal spore growth controls how dendritic cells (clearly THE best immune cell) trigger inflammation that causes asthma...