Very happy to announce that I will be starting my own lab as an assistant professor in the College of Pharmacy at the @umich.edu! I'm very excited to be joining the BioInnovations in Brain Cancer program, and really looking forward to contributing to the incredible work being done there.

The last paddle board of the season. 🍁🇨🇭

Phil and Penny Knight announced today a record-breaking $2 billion gift to the Oregon Health & Science University’s Knight Cancer Institute to transform the future of cancer care and set a new standard globally. Thank you to Phil and Penny Knight for their incredible generosity. #GiveCancerHell

🎉 New paper alert. We benchmarked Visium, GeoMx, and Chromium for FFPE tumor analysis. Thanks @estellayixingdong.bsky.social for pushing this forward, & MOSAIC collaborators! 📄 www.nature.com/articles/s41... #SpatialTranscriptomics #CancerResearch cc: @owkin.bsky.social @10xgenomics.bsky.social

Transcriptome analysis of archived tumors by Visium, GeoMx DSP, and Chromium reveals patient heterogeneity - Nature Communications

Currently, there is an urgent need to evaluate the strengths and limitations of various probe-based full transcriptome methods for formalin-fixed paraffin-embedded tumor tissues. Here, the authors ana...

nature.com

And wonderful photos by our in-house photographers/ drone specialists 📷👏 @drspencerwatson.bsky.social @dolfibastien.bsky.social 🙏 This group photo was captured by drone - a J for Joyce lab 😉 My thanks again to ~50 alumni & current lab members who joined over the 3 days of this truly unique event!!

Great to see this paper finally out. We've been using it for a while, a really great resource for omics in glioblastoma! doi.org/10.1093/neuo...

Charting the Single-Cell and Spatial Landscape of IDH-Wildtype Glioblastoma with GBmap

AbstractBackground. Glioblastoma (GB), particularly IDH-wildtype, is the most aggressive brain malignancy with a dismal prognosis. Despite advances in mole

doi.org

Thank you @naturemethods.bsky.social for highlighting our recent paper on "Spatial Mechano-Transcriptomics" in your April Issue: www.nature.com/articles/s41... www.nature.com/articles/s41...

A computational pipeline for spatial mechano-transcriptomics - Nature Methods

The authors present a computational framework that leverages mechanical force inference and spatial transcriptomics to enable analyses of the interplay between the transcriptomic and mechanical state.

nature.com

Nature Methods@natmethods.nature.com · 2y ago

Our April issue is live! 🌧️🌷 nature.com/nmeth/volume... On the cover, Spotiphy projects scRNA-seq and histological image data onto the spatial transcriptome. Artwork by Jiyuan Yang @stjuderesearch.bsky.social. Paper: www.nature.com/articles/s41...

Thrilled to announce our doctoral network for spatial oncology as been funded by Marie Skłodowska-Curie Actions! This combines some of the best immuno-oncology and computational labs across Europe to create a multi-disciplinary PhD program for spatial-omics cancer research. More details soon!

Please also check out the News & Views highlighting this cool work! www.nature.com/articles/s41...

Marrying mechanics with spatial transcriptomics - Nature Methods

A method infers tension from spatial transcriptomic data on single cells in tissue context.

nature.com

Nature Methods@natmethods.nature.com · 2y ago

A computational framework links transcriptomic analyses with mechanical signatures to study the interplay between cell mechanical forces and gene expression. www.nature.com/articles/s41...

What's better than spatial metabolomics? Spatial metabolomics in 3D! New from Ramon Sun and colleagues, a 3D map of the brain metabolome using AI, with an interactive database to explore. www.nature.com/articles/s42...

AI-driven framework to map the brain metabolome in three dimensions - Nature Metabolism

This study presents MetaVision3D, a pipeline to integrate mass spectrometry imaging sections into 3D reconstructions of metabolomic maps. The authors also provide a comprehensive 3D metabolome atlas o...

nature.com

Morning in Haute-Nendaz 🇨🇭

OMG, I feel so seen!

Kaia Mattioli@kaiamattioli.bsky.social · 2y ago

born too late to get a two Western blot Nature paper, born too early to be a science TikTokker, born just in time to start a postdoc during a global pandemic and look for faculty positions during a historic hiring freeze

Also, what’s this big orange thing in the sky over London? Never seen that here before.

Fantastic scientific advisory board meeting for @braintumourcharity.bsky.social Some great applications I’m excited to see funded. Thanks again for everything the Charity does to support cutting edge brain cancer research!

Check out this amazing visualization of SNSF funding by Colas Droin! Really highlights how Switzerland has become such a scientific leader through intelligent investments in research. colasdroin.github.io/snsf-dataviz/

Unbelievable news. Pancreatic is one of the deadliest cancers. New paper shows personalized mRNA vaccines can induce durable T cells that attack pancreatic cancer, with 75% of patients cancer free at three years—far, far better than standard of care. www.nature.com/articles/s41...

Evening in Lutry Switzerland

After a long journey, Segment Anything for Microscopy is now published in Nature Methods! We significantly improve SAM for interactive and automatic segmentation in light and electron microscopy and build a user-friendly tool. www.nature.com/articles/s41...

Exciting to see these approaches reach clinical trials.

Nature Biotechnology@natbiotech.nature.com · 2y ago

An AI-generated small-molecule inhibitor treats fibrosis in vivo and in phase I clinical trials go.nature.com/3IvPOuI rdcu.be/d8EOQ

It’s great to see these progressive changes by @ethzurich.bsky.social. It’s hard enough getting and starting an assistant professorship, removing barriers will be a huge gain for early career scientists and academic research in Switzerland. #EduSky #AcademicSky

RUNX2 promotes fibrosis via an alveolar-to-pathological fibroblast transition @nature.com www.nature.com/articles/s41...

RUNX2 promotes fibrosis via an alveolar-to-pathological fibroblast transition - Nature

The use of two mouse models of pulmonary fibrosis helped the identification of the transcription factor RUNX2 as a regulator of the transition of alveolar fibroblasts to pathological fibroblasts.

nature.com

I’m at the AI Moonshot Hackathon for glioblastoma in Paris, put on by Owkin and Servier. We have 15 teams working with spatial transcriptimics to develop new analyses for GBM. Excited to see what they come up with. #ScienceSky #CanSky #MedSky

In Paris today speaking at the Brain Tumor Microenvironment Symposium. It’s a very impressive lineup, really looking forward to it. It’s also my first time in Paris so would love some recommendations on what to do after the symposium. #CanSky #ScienceSky #MedSky curamus-cancer.fr/wp-content/u...

Spatial multi-omics has just gone to the next level! www.nature.com/articles/s41... www.nature.com/articles/s41... —Integration of 5 omic modalities w/ spatial resolution at 20 -50 μm —"a new era for characterizing tissue & cellular heterogeneity that single-modality studies alone could not reveal"

In London to speak at the British Neuropathological Society symposium. We'll be discussing how we can apply spatial-omics approaches to improve immunotherapies for glioblastoma patients. #CanSky #ScienceSky #MedSky www.bns.org.uk/126th-bns-me...

Deleted all FB/Insta/Meta accounts. Now I don’t have anywhere else to post cute pet pics. So for now on I’ll be posting about cutting edge cancer research, and random stuff my dog does. #ScienceSky #CanSky #AcademicSky

A new mechanism for cancer-induced immune evasion. We knew about cancer cells hijacking mitochondria. Now we learn about how their mitochondrial transfer to T cells impairs the tumor immune response. www.nature.com/articles/s41... www.nature.com/articles/d41...

Making space for spatial biology in the clinic Spatial transcriptomics methods have been slow to move into clinical practice, but spatial proteomics are cheaper and more scalable, and could progress faster go.nature.com/3PoWPkz

You cannot underestimate all the positive and long-term benefits of having a supportive #mentor One could argue this is at least as important as the research topic 🧪 Do choose wisely.. #MentoringMonth

Thrilled to share that our paper www.nature.com/articles/s41... is featured in a fantastic Nature News & Views piece by thomastueting.bsky.social! 🎉 Grateful for the spotlight on our research and its impact on understanding cancer immunology. www.nature.com/articles/d41... 👀👉 rdcu.be/d3cRz

A lipid made by tumour cells reprograms immune cells

Insights into how cancer cells become unresponsive to therapy.

nature.com