A stool transplant delivers billions of microbes into a sick gut. Almost none move in for good. We followed donor-recipient pairs from whole communities down to single nucleotides, and found the gut runs a ruthless strain-level filter. Out now in Cell Reports 🧵 www.cell.com/cell-reports...

Strain-level ecological filtering governs microbial colonization of the human gut

Baertschi et al. demonstrate that microbiota transplantation functions as a selective ecological filter. Although donor species frequently appear, only specific lineages achieve stable strain integrat...

cell.com

Universität Bern@unibe.ch · 3d ago

A strict “gatekeeper” decides whether a #fecaltransplant is effective: sohub.io/wruy. This is shown by a new study led by @bahtiyil.bsky.social from #unibern & @inselgruppe.bsky.social @dbmr-unibe.bsky.social

Obituary: Susumu Tonegawa, Japan’s first Nobel prizewinner in physiology or medicine www.nature.com/articles/d41...

Obituary: Susumu Tonegawa, Japan’s first Nobel prizewinner in physiology or medicine

Fearless molecular biologist who revealed the workings of antibodies and memories.

nature.com

Highly recommend 👇👇👇

Iannacone Lab@iannaconelab.bsky.social · 2w ago

🔬 Recruiting a Physician Scientist PhD student (San Raffaele, Milan) via AIRC-Cariplo-SEMM-UniMi program. Project: reprogramming tumor endothelium to restore anti-tumor immunity in liver cancer. Keep 20% clinical work. Deadline Sept 16. Apply: tinyurl.com/3vcp27dp #AIRC

🧬 Big news: our team at @gimminstitute.bsky.social and I have been awarded a €2.5M ERC Advanced Grant (#ERCAdG) for a project we couldn't resist naming KILLBILL. Yes, like the Tarantino film. Bear with me — the analogy runs deeper than the title. 🧵 ⚔️

An American leader who believes in science.

🧬 New findings from our lab @gimminstitute.bsky.social, out in iScience, led by PhD student Miguel Mesquita who defends his thesis very soon! We define a bilirubin threshold for malaria protection using catalytically deficient BVRA mouse mutants. 🔗 doi.org/10.1016/j.isci.2026.115958

🎟️Do you want to be part of a dynamic platform for dialogue and discovery? Register your Early Bird acess for GIMM Festival 2026, taking place 17–19 September in Lisbon, and hear from Charles Rice, Yasmine Belkaid and many others speakers. 🔗Register now: linktr.ee/gimm_institute

Red blood cells don't always make their own heme - under stress, they scavange it from neighbors. Our new paper in @ScienceMagazine reveals a cell-nonautonomous heme acquisition pathway essential for erythroid hemoglobinization. #heme #erythropoiesis #anemia www.science.org/doi/10.1126/...

A cell-nonautonomous heme acquisition pathway enables erythroid hemoglobinization under stress

Heme, an iron-containing cofactor, is synthesized in mitochondria by an eight-enzyme pathway. Although cells were thought to manage heme autonomously, more than 1000 proteins contribute to its product...

science.org

Applications are open for the Master in Biomedical Research (MIB)! Hands-on training at GIMM & FMUL. Cancer Biology, Neurosciences, Cardiovascular, Infection & Immunity. English-taught. Deadline: May 31. (@gimminstitute.bsky.social) Please share! medicina.ulisboa.pt/en/biomedical-research

Biomedical Research

We offer a multidisciplinary, transversal and integrated Master training from the bench to the bedside grounded on the four major areas of biomedical research: cell biology and cancer, neurosciences, ...

medicina.ulisboa.pt

This is the front cover of the new edition of @thelancet.com (thanks to @profstevegriffin.bsky.social for sharing) #HealthPolicy #Science 🧪🧵

Honoring immigrants in research: The Vilcek Prizes in Biomedical Science | Science | AAAS www.science.org/content/arti...

Honoring immigrants in research: The Vilcek Prizes in Biomedical Science

Diverse voices overcome scientific challenges

science.org

The biggest science breakthroughs in 2025 | Science | AAAS www.science.org/content/arti...

The biggest science breakthroughs in 2025

From supercharged cancer cells to the first personalized gene-editing therapy, last year was full of scientific advances

science.org

@elmiguelche.bsky.social from GIMM and Daniel Costa Gomes from ULSSM and FMUL are leading a project aimed at developing a multi-omics atlas for sepsis patients to identify cellular mechanisms that lead to organ failure.

Two days of scientific discussion and networking will be followed by a day open to the public — reinforcing our commitment to sharing research with society. Secure your ticket! 🔗 Get your ticket: fest.gimm.pt 🎟️ Early bird special rates

GIMM Fest returns September 17–19 with three days dedicated to the future of science and health, this year focusing on microbes. 🦠 Join researchers and innovators for a programme designed to promote scientific exchange and collaboration.

The great Ruslan Medzhitov strikes again!

On the balance of knowledge

Nature Reviews Immunology - Ruslan Medzhitov shares his thoughts on the balance between generating data and developing theories in immunology, with a focus on exploring the rules that govern...

nature.com

Join us for the 2026 GRC Immunochemistry and Immunobiology "Immune Circuitry and Molecular Pathways in Tissue Homeostasis, Infection, and Disease" in beautiful Barcelona. June 28 - July 3, 2026. Great lineup of speakers! www.grc.org/immunochemis...

Incredible science at the CAML-GIMM PhD Meeting 2026! So proud of the outstanding presentations from our GIMM students across both campuses. 🧬 The meeting showcased "home made" cutting-edge research! Congratulations to Sonia Trikha, Madalena Pereira and Miguel Mesquita! @gimmfoundation.bsky.social

#DirtyIsBetter! @rmedzhitov.bsky.social, Erickson &co show @nature.com that pet shop mice are protected from #allergy thanks to cross reactive type I (or tolerogenic) immune memory that prevents type II allergen-driven responses! doi.org/10.1038/s415...

Environmentally driven immune imprinting protects against allergy - Nature

In a mouse model, environmental immunostimulation in early life led to cross-reactive adaptive immune memory and reduced type II immune responses to allergens, indicating a mechanistic relationship be...

doi.org

Ageing rewires the body’s tolerance to infection www.nature.com/articles/d41...

Ageing rewires the body’s tolerance to infection

In life-threatening sepsis, the same signalling pathway that protects young mice from succumbing to organ dysfunction exacerbates damage and lethality in older animals.

nature.com

#WeekendRead! #SameSameButDifferent! #FirstLove! Its discovery changed our understanding of the functioning of innate immunity and of the immune response in general, but actually not all TLR4s are equal, check this out @jimmunol.bsky.social 👇👇👇 academic.oup.com/jimmunol/art...

TLR4al senses heme as a key damage/danger-associated molecular pattern to activate immune responses in lower vertebrates

Abstract. Toll-like receptor 4 (TLR4), a critical pattern recognition receptor, detects microbe- and damage/danger-associated molecular patterns to trigger

academic.oup.com

This is not an anomaly. It is a method. Correction becomes harassment Public discourse becomes “stalking” Expertise becomes abuse Evidence is replaced by narrative Sex and victimhood are instrumentalised Reputation damage is the objective

Disinformation: When falsehoods become a political identity

How storytelling is used as "investigation".

marcveldhoen.substack.com

New research led by @karinaxavierlab.bsky.social at 🇵🇹 @gimmfoundation.bsky.social demonstrates that a harmless strain of 🦠 #Klebsiella – discovered by chance in 🧫 laboratory experiments – can eliminate #infections and reduce gut inflammation in mouse models of inflammatory bowel disease. #IBD

Klebsiella strain to protect against IBD gut infections

A team of researchers led by Karina Xavier has uncovered a promising new live biotherapeutic agent that may redefine how the medical field approaches microbiota-based therapies.

healthcare-in-europe.com

1/10 🧵NEW PREPRINT: How does jaundice protect against malaria? We show it's ALL about biliverdin reductase (BVRA) catalytic activity and found the bilirubin threshold needed for protection. www.biorxiv.org/content/10.6...

Biliverdin Reductase Catalytic Activity Is Essential for Malaria Resistance

Jaundice, a condition characterized by elevated levels of circulating bilirubin, is an adaptive response to malaria sustained through bilirubin production by biliverdin reductase A (BVRA). Beyond its ...

biorxiv.org

@EMBO Practical Course Pipetting scRNA-seq data into computational cells 18 – 23 May 2026 | Oeiras/Lisbon, Portugal @gimmfoundation.bsky.social Registration open!

Pipetting scRNA-seq data into computational cells

Single-cell transcriptomics is transforming biology, uncovering hidden cell states, dynamic transitions, and intricate interactions across systems from immunity to cancer. Yet as these technologies s…

meetings.embo.org

Homeostatic control of energy metabolism by monocyte-derived macrophages @elmiguelche.bsky.social and colleagues show that macrophages sense dysregulated iron metabolism in parenchymal cells and respond by sustaining mitochondrial function in affected cells www.embopress.org/doi/full/10....

🧵 Thrilled to share our new work in @embojournal! Over a century after Metchnikoff recognized macrophages as central to organismal homeostasis, we reveal how they act as metabolic guardians through an unexpected mechanism. www.embopress.org/doi/full/10.... (1/9)

Homeostatic control of energy metabolism by monocyte-derived macrophages | The EMBO Journal

imageimageMacrophages play critical roles in the homeostatic control systems that maintain vital parameters within physiological ranges. This study characterizes how mouse monocyte-derived macrophages...

embopress.org

of the influenza vaccine is low (against infection). What is forgotten is the protection from non-communicable diseases. What if you could reduce your risk to heart disease by 40%? What is you could reduce you risk to dementia by at least 10%? That is what vaccines do! 3/10

Food for thought from: ‪@lferreiramoita.bsky.social‬ in JCI - Biological and clinical implications of a model of surveillance immunity www.jci.org/articles/vie...

At Folha de São Paulo: folha.com/38iy72bz @gimmfoundation.bsky.social

Bilirrubina, pigmento amarelado natural do corpo, pode combater a malária

Substância controla doença de várias maneiras; pesquisador espera que, no futuro, seja possível usar descoberta em terapias

folha.com