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Emmanuelle Bignon

@emmabignon.bsky.social

Computational biochemistry, histone PTM, DNA damage, nucleosomes... fun stuff! | Young PI @ LPCT lab, Nancy, France | She/her

4 Posts163 Follower203 Folgt
FragileNucleosome@fnucleosome.bsky.social · 2y ago

Our speaker application is still open! Fill out the survey to come share your research with the Fragile Nucleosome community!

FragileNucleosome@fnucleosome.bsky.social · 2y ago

Do you have a new and exciting chromatin/transcription story that you'd like to share with an enthusiastic audience? If so, you should apply to give a talk in the 2025 Fragile Nucleosome seminar series: forms.gle/fwMYPFDf4az3...! We're open to scientists at all stages of their careers!

Siavash@siavashk.bsky.social · last yr.

Ever wondered what the lonely histone H3C110 does? We found that it’s lost in many fungi. Adding it back boosts histone H3 copper reductase activity, rescues iron defects and modulates lifespan, suggesting an evolutionary tradeoff between these effects. www.science.org/doi/10.1126/...

Histone H3 cysteine 110 enhances iron metabolism and modulates replicative life span in Saccharomyces cerevisiae

Histone H3 cysteine 110 enhances iron metabolism and modulates replicative life span in yeast.

science.org

Jon Markert@jonmarkert.bsky.social · last yr.

Take a look at our new collaboration project with the Phil Cole lab, we demonstrate how SIRT6 can recognize and remove a variety of different Histone acylations!

Lucas Farnung@lucas.farnunglab.com · last yr.

🚨New paper🚨Our new study with the lab of Phil Cole uncovers how SIRT6 dynamically adapts structurally and enzymatically to target diverse histone acylations (e.g., H3K27ac) within nucleosomes. @jonmarkert.bsky.social doi.org/10.1016/j.jb... #Chromatin #SIRT6 #CryoEM

Emmanuelle Bignon@emmabignon.bsky.social · 2y ago

It is still possible to apply to this postdoc position in my group if you are motivated by using your QM/MM and MD skills to study the fascinating histone post-translational modifications! 🥳 Deadline is the 1st of March #job #compchem #histones #DNA Apply on the CNRS website : lnkd.in/eNxR-TPH

Emmanuelle Bignon@emmabignon.bsky.social · 2y ago

First post here, how exciting!! 🥳 📣💻[JOB OFFER] I am looking for a postdoc with experience in QM/MM, MD and biosystems, and who would be motivated to study the formation mechanisms of oxydative histone modifications. Please share! #compchem #histones #PTM #redox www.linkedin.com/posts/activi...

Tyler Weaver@tmweaver.bsky.social · 2y ago

My lab is looking to hire a Postdoc to study mechanisms of DNA repair in chromatin using biochemical, biophysical, and structural biology approaches! Feel free to share with anyone you think may be interested. jobs.virginia.edu/us/en/job/R0...

Postdoctoral Research Associate in Biochemistry and Molecular Genetics – Weaver Lab in Charlottesville, Virginia, United States of America | Research at University of Virginia

Apply for Postdoctoral Research Associate in Biochemistry and Molecular Genetics – Weaver Lab job with University of Virginia in Charlottesville, Virginia, United States of America. Research at Univer...

jobs.virginia.edu

Nogales Lab@nogaleslab.bsky.social · 2y ago

Work led by graduate student @trinitycookis.bsky.social and coauthors Alexandria Lydecker, @paulsauer.bsky.social, and @kasinath-lab.bsky.social is out today where we looked at the inhibition of PRC2 by histone PTMs associated with regions of active transcription. www.nature.com/articles/s41...

Structural basis for the inhibition of PRC2 by active transcription histone posttranslational modifications - Nature Structural & Molecular Biology

Structures reveal that histone H3K36me3 and H3K4me3 modifications reduce Polycomb repressive complex 2 (PRC2) function through the inhibition of histone tail engagement and antagonistic binding to the...

nature.com

Marcelo Bonini, Ph.D.@mbonini.bsky.social · 2y ago

2024 - the year when we showed that chromatin structure is responsive to ROS regulation because of redox sensitive histone variants - more #redoxepigenetics in 2025 folks - thanks 2024 looking forward to an awesome 2025 www.cell.com/cell-reports...

Histone H3.1 is a chromatin-embedded redox sensor triggered by tumor cells developing adaptive phenotypic plasticity and multidrug resistance

Palma et al. report that H3.1Cys96 oxidation is a functional posttranslational modification involved in the regulation of gene expression. In breast cancer, H3.1Cys96 oxidation promotes resistance to first-line chemotherapeutic drugs and stimulates metastasis. They also show that suppressing H3.1Cys96 oxidation inhibits metastasis while resensitizing cancer cells to chemotherapy.

cell.com

@paulschanda.bsky.social · 2y ago

Open #PhDposition: decipher the mechanisms underlying allostery. What allows a protein to communicate over many nanometers to regulate its function? How did it evolve? What is the link to protein dynamics? Join us to study exciting mechanisms by NMR & more. More info attached. phd.pages.ista.ac.at

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Emmanuelle Bignon@emmabignon.bsky.social · 2y ago

First post here, how exciting!! 🥳 📣💻[JOB OFFER] I am looking for a postdoc with experience in QM/MM, MD and biosystems, and who would be motivated to study the formation mechanisms of oxydative histone modifications. Please share! #compchem #histones #PTM #redox www.linkedin.com/posts/activi...

Emmanuelle Bignon on LinkedIn: Job offer - pdoc CHROM

📢🧬I have a postdoc position open for people with experience using QM/MM on biosystems! Do not hesitate to apply if you're interested in investigating the…

linkedin.com