🚨 New from our lab: Here we explored how aging contributes to harmful protein aggregation in diseases like Huntington’s & ALS. The culprit? An overlooked aging factor — EPS8 and RAC signaling. #Aging #Longevity #Proteostasis #ALSResearch 🧵 www.nature.com/articles/s43...

The aging factor EPS8 induces disease-related protein aggregation through RAC signaling hyperactivation - Nature Aging

Aging is a risk factor for neurodegenerative diseases associated with protein aggregation. Here the authors identify age-related hyperactivation of EPS8/RAC signaling in C. elegans as a driver of path...

nature.com

New work from the lab! C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules - Bilican - FEBS Letters - Wiley Online Library febs.onlinelibrary.wiley.com/doi/10.1002/...

FEBS Press

Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient-derived neurons and C. elegans models, w...

febs.onlinelibrary.wiley.com

I am beyond excited and incredibly proud to share that our work is now out in @nature.com This discovery was made possible thanks to the first author Kostas kelepouras, my fantastic lab , and the unique research environment here in Cologne in collaboration with the Hospital bambino Gesu in Rome.

Congratulations Debora, fantastic news!

Trentini Lab@trentini-lab.bsky.social · last yr.

🚨 Happy to share our first pre-print 🎉 on the causes of ribosome-associated degradation of CFTR and other transmembrane proteins. We explore how protein folding, ER insertion, and elongation dynamics influence translation arrests in this new class of RQC targets.👇 www.biorxiv.org/content/10.1...

DynaTag for efficient mapping of transcription factors in low-input samples and at single-cell resolution @natcomms.nature.com @epistrucstab.bsky.social www.nature.com/articles/s41...

DynaTag for efficient mapping of transcription factors in low-input samples and at single-cell resolution - Nature Communications

Transcription factors shape cell identity, but mapping their genomic targets remains challenging. Here the authors present DynaTag, a modified CUT&Tag method for profiling TF occupancy in bulk and...

nature.com

A great skeetorial on a new and much improved method for mapping transcription factor landscapes, with a beautiful image by our own Gloria Fuentes @gloglita.bsky.social from Life Science Editors @lifescienceeditors.bsky.social

Robert Hänsel-Hertsch@epistrucstab.bsky.social · last yr.

🧪Move over CUT&Tag, there’s a new #TranscriptionFactor mapping method in town. Our newly developed DynaTag is faster, cleaner, more sensitive than #ChIPseq, #CUT&RUN and #CUT&Tag. 🔗 Our @natcomms.nature.com paper: www.nature.com/articles/s41... 🧵Let’s break down what makes DynaTag so powerful (1/7)

🚀Big news from CRC 1678! Robert Hänsel-Hertsch @epistrucstab.bsky.social and team unveil DynaTag—a single-cell method to map protein-DNA binding with stunning precision. Outshines ChIP-seq & CUT&RUN. 🧬Cancer research & gene regulation just got a major upgrade. #Genomics #DynaTag #PrecisionMedicine

Robert Hänsel-Hertsch@epistrucstab.bsky.social · last yr.

🧪Move over CUT&Tag, there’s a new #TranscriptionFactor mapping method in town. Our newly developed DynaTag is faster, cleaner, more sensitive than #ChIPseq, #CUT&RUN and #CUT&Tag. 🔗 Our @natcomms.nature.com paper: www.nature.com/articles/s41... 🧵Let’s break down what makes DynaTag so powerful (1/7)

🔬 DynaTag by CRC 1678 project leader Robert Hänsel-Hertsch @epistrucstab.bsky.social maps protein-DNA binding at single-cell level—boosting precision in cancer & gene research. #CRC1678 #DynaTag #UniCologne

Universität zu Köln@unicologne.bsky.social · last yr.

🔬 New: Method for mapping protein-DNA interactions developed 💡 @epistrucstab.bsky.social #UniCologne has developed DynaTag, a method that detects the binding of proteins to DNA even in a single cell. This is crucial for gene regulation and the development of diseases like cancer. 🧬👇 uni.koeln/LXJQE

🧪New method for anyone interested in protein-DNA interactions and TF mapping, from the lab of @epistrucstab.bsky.social at @unicologne.bsky.social!👇

Robert Hänsel-Hertsch@epistrucstab.bsky.social · last yr.

🧪Move over CUT&Tag, there’s a new #TranscriptionFactor mapping method in town. Our newly developed DynaTag is faster, cleaner, more sensitive than #ChIPseq, #CUT&RUN and #CUT&Tag. 🔗 Our @natcomms.nature.com paper: www.nature.com/articles/s41... 🧵Let’s break down what makes DynaTag so powerful (1/7)

Highly recommended read for everyone interested in interactions of proteins and DNA: Impressive new method on single cell level introduced by @epistrucstab.bsky.social from @unicologne.bsky.social!

Universität zu Köln@unicologne.bsky.social · last yr.

🔬 New: Method for mapping protein-DNA interactions developed 💡 @epistrucstab.bsky.social #UniCologne has developed DynaTag, a method that detects the binding of proteins to DNA even in a single cell. This is crucial for gene regulation and the development of diseases like cancer. 🧬👇 uni.koeln/LXJQE

Die neue Methode übertrifft bestehende Methoden wie #ChIP-seq und #CUT&RUN in Bezug auf Sensitivität und Auflösung der Ergebnisse. 📈 Die Studie wurde in ‪@natcomms.nature.com‬ veröffentlicht👇 www.nature.com/articles/s41...

DynaTag for efficient mapping of transcription factors in low-input samples and at single-cell resolution - Nature Communications

Transcription factors shape cell identity, but mapping their genomic targets remains challenging. Here the authors present DynaTag, a modified CUT&Tag method for profiling TF occupancy in bulk and...

nature.com

🔬Neue Methode zur Kartierung von Proteinbindung an DNA entwickelt💡 @epistrucstab.bsky.social #UniKöln hat DynaTag entwickelt, eine Methode, die die Bindung von Proteinen an die DNA sogar in einer einzelnen Zelle nachweist 🧬👇https://uni.koeln/SCLU6

Neue Methode zur Kartierung von Proteinbindung an DNA entwickelt

Ein Forschungsteam der Universität zu Köln hat eine Methode mit dem Namen DynaTag entwickelt, die die Bindung von Proteinen an die DNA sogar in einer einzelnen Zelle nachweist. Interaktionen von Prote...

uni.koeln

🧪Move over CUT&Tag, there’s a new #TranscriptionFactor mapping method in town. Our newly developed DynaTag is faster, cleaner, more sensitive than #ChIPseq, #CUT&RUN and #CUT&Tag. 🔗 Our @natcomms.nature.com paper: www.nature.com/articles/s41... 🧵Let’s break down what makes DynaTag so powerful (1/7)

Very proud of Dalya Hiluf being among the poster prize winners at the recent EMBO | EMBL Symposium 'The ageing genome'. Great stuff and congratulations!

🧬🖥️ SARS-CoV-2 mRNA vaccination induces persistent H3K27 acetylation at macrophage promoters; especially those in guanine-rich DNA regions. Adds to my understanding of "immune training". Work by Jan Rybniker, @epistrucstab.bsky.social & teams in @molsystbiol.org www.embopress.org/do... 🧪

Very nice paper showing that mRNA vaccines not merely elicit adaptive responses, but also epigenetically train innate immunity, too. 👇🏻👇🏻

New research by Jan Rybniker and @epistrucstab.bsky.social reveals that the SARS-CoV-2 mRNA vaccine triggers innate immune memory by establishing persistent H3K27ac epigenetic marks in human macrophages. Two consecutive doses are needed for this persistence ➡️ www.embopress.org/doi/full/10....

Something positive on a topic that influenced us in so many ways. Happy that Jan and his team approached me to be a part of this endeavour. I‘m grateful to all my supporters, my lab, and funders. @crc1678.bsky.social #crc1399 #RU5504 #CMMC @cecad.bsky.social @dfg.de #Fritz_Thyssen_Foundation

Universität zu Köln@unicologne.bsky.social · last yr.

🧬💡 #mRNA vaccines against COVID-19 not only trigger classical #immuneresponses, but also have a persistent effect on the innate #immunesystem📚 That shows a study by the team of Jan Rybniker and @epistrucstab.bsky.social #UniCologne in Molecular Systems Biology @embopress.org🦠👇 uni.koeln/43N7Y #covid

Something positive on a topic that influenced us in so many ways. Happy that Jan and his team approached me to be a part of this endeavour. I‘m grateful to all my supporters, my lab, and funders. @crc1678.bsky.social #crc1399 #RU5504 #CMMC @cecad.bsky.social @dfg.de #Fritz_Thyssen_Foundation

Universität zu Köln@unicologne.bsky.social · last yr.

🧬💡 mRNA-Impfstoffe gegen COVID-19 rufen nicht nur klassische Immunantworten hervor, sondern prägen langfristig auch das angeborene #Immunsystem. 💉 Das zeigt ein Team um Jan Rybniker und @epistrucstab.bsky.social der #UniKöln und @uniklinikkoeln.bsky.social 🦠 👇 uni.koeln/EXDKG #mrna #Impfung #covid