Daniel Friedrich
@friedrichlab.bsky.social
Research Group Leader and Head of #NMR Facility @chemunicologne.bsky.social at @unicologne.bsky.social | We are interested in structural analysis of proteins, peptides and nucleic acids. https://friedrichlab.uni-koeln.de/
Love these starter-packs! 👇
Magnetic Resonance News@nmr900.bsky.social · 8mo agoBlueSky Magnetic Resonance Starter Packs #NMRchat #NMR #MRI #EPR #ESR 🧲 Magnetic Resonance bsky.app/starter-pack... NMRchat bsky.app/starter-pack... MagRes bsky.app/starter-pack... EPR-ESR Spectroscopy bsky.app/starter-pack...
We are very happy to share our new publication in the European Journal of Medicinal Chemistry on #antiviralpeptides against SARS-CoV-2 and their #NMR-based structural characterisation: www.sciencedirect.com/science/arti...
Aromatic π-Stacking Stabilizes an α-Helical SARS-CoV-2 MPER Peptide that Mimics the Post-Fusion Spike and Enables Potent Antiviral Activity
Membrane fusion between SARS-CoV-2 and host cells is mediated by the spike protein and involves the membrane-proximal external region (MPER), a trypto…
sciencedirect.com
Many thanks again for the great collaboration @gabriellapetti.bsky.social and @teamthomma.bsky.social!
Team Thomma@teamthomma.bsky.social · 2mo ago📣Last week another @biorxivpreprint.bsky.social dropped: "A fungal pathogen effector that shapes host plant microbiota kills bacteria through lipoteichoic acid binding and membrane disruption" a joint effort by @nicksnelders.bsky.social & @gabriellapetti.bsky.social www.biorxiv.org/content/10.6...
Congratulations @gabriellapetti.bsky.social and @teamthomma.bsky.social on this fantastic study! It has been a pleasure collaborating with you, and we are very happy to have contributed with #NMR to such an exciting project. We truly enjoyed working together with you!
Gabriella Petti@gabriellapetti.bsky.social · 2mo agoExcited to share our latest study with @nicksnelders.bsky.social and @teamthomma.bsky.social! We uncover the mode of action of the V. dahliae antimicrobial effector Ave1 and show that it binds LTA and disrupts bacterial membranes 🦠 www.biorxiv.org/cgi/content/...
Excited to share our latest study with @nicksnelders.bsky.social and @teamthomma.bsky.social! We uncover the mode of action of the V. dahliae antimicrobial effector Ave1 and show that it binds LTA and disrupts bacterial membranes 🦠 www.biorxiv.org/cgi/content/...
biorxiv.org
Really happy with the relaunch of the University of Cologne website by @unicologne.bsky.social! We also updated the webpage of our NMR research group at @chemunicologne.bsky.social – feel free to check it out: friedrichlab.uni-koeln.de @friedrichlab.bsky.social
Friedrich Lab
friedrichlab.uni-koeln.de
Making invisible excited-state structures of pro-interleukin-18 visible by combining NMR and machine learning @PNAS.org
Making invisible excited-state structures of pro-interleukin-18 visible by combining NMR and machine learning
Proceedings of the National Academy of Sciences, Volume 123, Issue 16, April 2026. SignificanceIn many cases accurate models of the low energy, most populated form of a protein’s three-dimensional structure can be rapidly determined using machine learning (ML) programs, such as AlphaFold. However, biomolecular function is often ...
dlvr.it
Excited to share a new preprint from our group @chemunicologne.bsky.social @unicologne.bsky.social! chemrxiv.org/doi/full/10.... Big thanks to our collaborators at University of Florence! #NMR #StructuralBiology #AntiviralResearch #Peptides #SARSCoV2 #DrugDesign #Biophysics #Collaboration
Aromatic π-Stacking Stabilizes an α-Helical SARS-CoV-2 MPER Peptide that Mimics the Post-Fusion Spike and Enables Potent Antiviral Activity | ChemRxiv
Membrane fusion between SARS-CoV-2 and host cells is mediated by the spike protein and involves the membrane-proximal external region (MPER), a tryptophan-rich sequence implicated in viral entry. Here, we investigated the feasibility of MPER-derived ...
chemrxiv.org
📢 New preprint alert! How do proteins enter mitochondria? We uncovered a surprising mechanism at the mitochondrial entry gate—using #NMR, in vivo single-particle tracking, yeast experiments, and MD simulations to crack the code. www.biorxiv.org/content/10.6... #StructuralBiology #Mitochondria 🧵 1/8
A dynamic displacement mechanism drives protein import into mitochondria
Most mitochondrial proteins are produced in the cytosol and imported through the translocase of the outer mitochondrial membrane (TOM) to reach their final destination. Although this protein entry gat...
biorxiv.org
#EMA_award 🎖️ Nominations wanted for the 2026 #EMA Young Scientist Award by January 31, 2026! The Young Scientist Award is awarded annually to a young scientist for work in the field of magnetism, mainly carried out in Europe. All details and nomination forms are available here buff.ly/M2ADnNe
@jacs.acspublications.org (open) Hyperpolarized NMR Reveals Low-Populated Folding Intermediates in DNA, Milan Zachrdla, Ertan Turhan, Michala Bučková, Robert Hänsel-Hertsch, Lukáš Trantírek* @ceitec.eu Dennis Kurzbach* @univie.ac.at pubs.acs.org/doi/10.1021/... #NMRchat 🧲
Hyperpolarized NMR Reveals Low-Populated Folding Intermediates in DNA
Nuclear magnetic resonance (NMR) spectroscopy is the only biophysical technique capable of characterizing nucleic acid structures at atomic resolution under near-physiological liquid-state conditions. Still, it is fundamentally limited by intrinsically low sensitivity, particularly when analyzing high-molecular-weight, low-abundance, or polymorphic targets, such as DNAs (DNA). In this study, we demonstrate that hyperpolarized aqueous buffers generated via dissolution dynamic nuclear polarization (dDNP) significantly enhance the 1H NMR signals of multiple DNA motifs. The resonances of labile imino and amino protons of DNAs dissolved in hyperpolarized buffers are enhanced up to ∼200-fold and ∼370-fold, respectively. These intense signals serve a 2-fold purpose: (i) as structural fingerprints of DNA folding topologies and (ii) they enable the direct observation of low-populated folding intermediates in DNA polymorphs, such as G-quadruplexes (G4) and i-motifs (iM), which remain undetectable by standard methods. Thus, our findings establish hyperpolarized NMR as a high-sensitivity method for probing DNA structures and folding intermediates across a wide range of motifs, opening possible avenues in liquid biopsy applications and cell-free DNA.
pubs.acs.org
@instruct-eric.bsky.social webinar: Structure Meets Function! Explore the power of #NMR spectroscopy and its impactful applications in #structuralbiology, #drugdiscovery, and #metabolomics here at CERM/CIRMMP! Register now! events.teams.microsoft.com/event/d9ac1b...
New publication alert 🎉 Our latest paper explores how small molecules can bind SARS-CoV-2 RNA, combining in silico screening with NMR experiments to uncover promising RNA-targeting candidates. full text: chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/... #RNA #NMR #screening #drugtargeting
Integrative In Silico and In Vitro Screening of Low Molecular Weight Compounds Targeting SARS‐CoV‐2 RNA Elements
A combined virtual and nuclear magnetic resonance (NMR)-based screening approach identifies small molecules that bind conserved SARS-CoV-2 RNA structures. Diverse compound libraries are screened usin...
chemistry-europe.onlinelibrary.wiley.com
Happy Thanksgiving! It’s been indeed a fantastic event and I’m grateful to join the inspiring Fulbright-Cottrell scholars and this great community. I’m looking forward to work together on innovative concepts in combining teaching and research!
guenther@thielelabs.bsky.social · 8mo agoGreat Thanksgiving 🦃 and networking 🕸️ event with an amazingly productive and creative Work-Brunch. Always fun to get together with the gang, and congrats to the new awardees @lisavondung.bsky.social @friedrichlab.bsky.social. with @hellmichgroup.bsky.social but missing @esteslab.bsky.social
#research #hydrogenbonding NMR spectroscopy studies of hydrogen bonding (Dračínský) – Coord. Chem. Rev.: doi.org/10.1016/j.cc... @iocbprague.bsky.social @czechacademy.bsky.social
Josef Zwanziger, @aaronrossini.bsky.social, and I published a rebuttal of a recent Nature Commun. paper claiming that enantiomers produce large differences in J coupling constants. doi.org/10.1038/s414...
DFT calculations and theory do not support enantiospecificity in NMR J-coupling constants - Nature Communications
Nature Communications - DFT calculations and theory do not support enantiospecificity in NMR J-coupling constants
doi.org
Very nice article from @lek-lab.bsky.social including @roesslph.bsky.social, A. Sever and R. Ahmed, enjoyed reading it! #NMR
Magnetic Resonance News@nmr900.bsky.social · 9mo agoSolution NMR goes big: Atomic resolution studies of protein components of molecular machines and phase-separated condensates, Alexander I.M. Sever, Rashik Ahmed, Philip Rößler, Lewis E. Kay* @lek-lab.bsky.social @utoronto.ca www.sciencedirect.com/science/arti... #NMRchat 🧲
Fantastic opportunity to work on exciting projects with a great team @etzkornlab.bsky.social!
Etzkorn Lab@etzkornlab.bsky.social · 9mo agoWe are hiring! The Etzkorn Lab is looking for up to 7 highly motivated PostDocs and 1-2 PhD candidates to support our endeavour to translate the DNAzyme technology into therapeutic applications. For more information see: www.ipb.hhu.de/fileadmin/re... Please repost. #Postdoc, @hhu.de
Our work on DNA G4 interactions with Zuo1 in collaboration with @paeschkelab.bsky.social and the Penedo lab is out in @narjournal.bsky.social 😍 Full text: academic.oup.com/nar/article/... #G4 #G-Quadruplex #NMR #smFRET #ChIP-qPCR
The Zuo1 C-terminal domain stabilizes DNA guanosine quadruplex (G4) structures located on Chromosome IX in Saccharomyces cerevisiae
Abstract. Deoxyguanosine quadruplexes (G4s) form stable non-B-DNA structures that can affect transcription, replication, and genome stability. Depending on
academic.oup.com
📢 Open Call! The Max Perutz Labs invite applications for a Full Professorship in Integrative Structure Biology with a focus on in situ structural biology using cryo-electron tomography (cryo-ET) and related methods. More details ➡️ tinyurl.com/brswbymu
Darja combines organic-chemistry synthesis (with our great collaborator Roman Lichtenecker) of specifically isotope-labeled amino acids with protein NMR in solution and solids. 👉 Synthesis and proof of principle is here: chemistry-europe.onlinelibrary.wiley.com/doi/full/10.... 2/n
Synthesis of Selectively 13C/2H/15N‐ Labeled Arginine to Probe Protein Conformation and Interaction by NMR Spectroscopy
We offer a new labeling approach to introduce isolated 15N−13C−1H spin systems to the side chains of arginine residues. The labeling scheme delivers high-resolution NMR spectra to study large protein....
chemistry-europe.onlinelibrary.wiley.com
Really interesting to see some basic science research coming out of Apple Inc. SimpleFold: Folding Proteins is Simpler than You Think arxiv.org/abs/2509.184... tldr: Apple used flow matching models to more efficiently predict protein folding structures. More of this, please... from ALL big tech.
SimpleFold: Folding Proteins is Simpler than You Think
Protein folding models have achieved groundbreaking results typically via a combination of integrating domain knowledge into the architectural blocks and training pipelines. Nonetheless, given the suc...
arxiv.org
Congratulations to the Behrmann and Schwarz labs at Institute of Biochemistry @chemunicologne.bsky.social for this fantastic work! 🎉 #StructuralBiology in Cologne is on fire 💥
Universität zu Köln@unicologne.bsky.social · 11mo ago🧠 How Synapses Hold Together 🤝 This #discovery was made by a research team @bccologne.bsky.social studying the molecular architecture of #synapses. The study shows that the protein #gephrin forms flexible filaments in the brain, serving as an important building block of inhibitory synapses.
I enjoyed the talk by Harald Schwalbe @schwalbe-lab.bsky.social very much, especially the #NMR work on #RNA structure and dynamics! #FGMR #GDCh
Schwalbe Lab@schwalbe-lab.bsky.social · 11mo agoAt the 2025 meeting of the German focus group of Magnetic Resonance (FGMR, EPR/NMR), Harald Schwalbe, Instruct-director, introduced access possibilities and highlighted the recent installation of the German Instruct centre. @instruct-eric.bsky.social @gdch.de #NMR #EPR #FGMR #GDCh #InstructERIC
Postdoctoral position in viral protein NMR, Prof Anja Böckmann, The protein solid-state NMR laboratory within the Molecular Microbiology and Structural Biochemistry (MMSB) unit in the Lyon Gerland Bioscience Campus mmsb.cnrs.fr/en/ emploi.cnrs.fr/Offres/CDD/U... #NMRjobs #NMRchat 🧲
Portail Emploi CNRS - Offre d'emploi - Postdoctoral position in viral protein NMR (M/F)
emploi.cnrs.fr
Very nice work by the Wöhnert group, determining an intersting RNA structure using #NMR!
Schwalbe Lab@schwalbe-lab.bsky.social · 11mo agoExciting work from Duchardt-Ferner et al. in NAR: high-res. NMR structure of a tobramycin-responsive riboswitch. Shows a novel aminoglycoside-binding RNA motif with unique RNA-RNA contacts, explaining its exceptional switching efficiency in eukaryotic translation. academic.oup.com/nar/article/...
Exciting work from Duchardt-Ferner et al. in NAR: high-res. NMR structure of a tobramycin-responsive riboswitch. Shows a novel aminoglycoside-binding RNA motif with unique RNA-RNA contacts, explaining its exceptional switching efficiency in eukaryotic translation. academic.oup.com/nar/article/...
Structural basis for ligand recognition in the tobramycin riboswitch
Abstract. Recently, a novel tobramycin-responsive riboswitch was developed by a combination of Capture-SELEX and in vivo screening. This riboswitch regulat
academic.oup.com
New publication: Arginine dynamics probed by magic-angle spinning NMR with a specific isotope-labeling scheme Our selective arginine labeling yields well-resolved 1H-detected spectra in solids (and solution). We apply it to study dynamics in crystalline ubiquitin and a >130 kDa large enzyme 1/2
Very interesting #NMR work on disordered proteins by the lab of @millessigrid.bsky.social at @fmp-berlin.de! Enjoyed reading it, congrats to this study!
Sigrid Milles@millessigrid.bsky.social · 12mo agoI am happy to share our new article on dynamic Eps15 and Dab2 networks in endocytosis studied by #NMR, and forming #LLPS. Research was done at @fmp-berlin.de and at the Institut de Biologie Structurale (IBS). www.nature.com/articles/s41...
