David Vilchez
@thevilchezlab.bsky.social
Biologist, Professor at CECAD, University of Cologne. We study aging, age-related diseases, stem cell biology and proteostasis. http://www.davidvilchezlab.com/
Bridging omics and physiology to build multimodal clocks of human aging: Cell www.cell.com/cell/fulltex...
Bridging omics and physiology to build multimodal clocks of human aging
Human aging is a heterogeneous, multi-system process that spans molecular, tissue, and physiological decline. In this issue of Cell, Li et al. integrate clinical data, multi-omics, and organ-associate...
cell.com
RESEARCH | PX Chen, Y Tian et al. (CAS) Mitochondrial superoxide production preserves nuclear envelope integrity by controlling lipid peroxidation, with impact on ageing in C. elegans 🧪
Mitochondrial superoxide regulates nuclear envelope integrity and ageing via redox-mediated lipid metabolism - Nature Metabolism
Mitochondrial superoxide production is shown to preserve nuclear envelope integrity by controlling lipid peroxidation, with impact on nuclear and organismal ageing in C. elegans.
dlvr.it
👩🔬 Today is International Day of Women and Girls in Science! Meet Dunja Petrovic, postdoctoral researcher in the group of @thevilchezlab.bsky.social at the @unicologne.bsky.social
Our new review on proteostasis of organelles in aging & disease is now online in The FEBS Journal! We discuss recent insights on how #proteostasis safeguards organelle integrity and function across the cell in #aging and disease doi.org/10.1111/febs...
FEBS Press
Cells rely on regulated proteostasis mechanisms to keep their internal compartments functioning properly. When these mechanisms fail, damaged proteins accumulate, disrupting organelles, such as the n....
doi.org
Saygin’s new ALS paper — showing nucleoporin alterations — just made the journal front cover @febsletters.bsky.social febs.onlinelibrary.wiley.com/doi/10.1002/... febs.onlinelibrary.wiley.com/doi/10.1002/...
FEBS Press
Cover illustration Stress granules in iPSCs treated with arsenite (G3BP1 (green) / NUP107 (red) / Hoechst (nucleus)). Image credit: Saygin Bilican. The image refers to Bilican et al., “C9orf72 ALS-ca....
febs.onlinelibrary.wiley.com
🚨Check out this new study from our Research Unit member @bjornschumacher.bsky.social on gene expression patterns linked to age deceleration and rejuvenation during Dauer Diapause. Congratulations! 🎉
Björn Schumacher@bjornschumacher.bsky.social · 10mo ago🚀 🚀 🚀 Our latest paper is out now: Age Deceleration and Reversal Gene Patterns in Dauer Diapause. We can learn from nature how aging of a whole organism with completely differentiated tissues can be slowed and how that organism can be completely rejuvenated. onlinelibrary.wiley.com/doi/10.1111/...
www.cell.com/cell/abstrac... A host organelle (in sea slugs) integrates stolen chloroplasts for animal photosynthesis
A host organelle integrates stolen chloroplasts for animal photosynthesis
Sea slugs steal foreign chloroplasts and store them in specialized organelles that facilitate photosynthesis and eventual digestion to mediate starvation resistance.
cell.com
🧓Wie das Altern neurodegenerative Krankheiten treibt 🧠 @thevilchezlab.bsky.social @cecad.bsky.social hat einen direkten molekularen Zusammenhang zwischen Altern und neurodegenerativen Krankheiten identifiziert.
🧓How aging drives neurodegenerative diseases🧠 @thevilchezlab.bsky.social @cecad.bsky.social has identified a direct molecular link between aging and neurodegeneration by investigating how age-related changes in cell signalling contribute to toxic protein aggregation.
🚨 New from our lab: Here we explored how aging contributes to harmful protein aggregation in diseases like Huntington’s & ALS. The culprit? An overlooked aging factor — EPS8 and RAC signaling. #Aging #Longevity #Proteostasis #ALSResearch 🧵 www.nature.com/articles/s43...
The aging factor EPS8 induces disease-related protein aggregation through RAC signaling hyperactivation - Nature Aging
Aging is a risk factor for neurodegenerative diseases associated with protein aggregation. Here the authors identify age-related hyperactivation of EPS8/RAC signaling in C. elegans as a driver of path...
nature.com
New work from the lab! C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules - Bilican - FEBS Letters - Wiley Online Library febs.onlinelibrary.wiley.com/doi/10.1002/...
FEBS Press
Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient-derived neurons and C. elegans models, w...
febs.onlinelibrary.wiley.com
Shuttle and stabilize: H1.2-FUS complex in amyotrophic lateral sclerosis pathogenesis journals.lww.com/nrronline/ci...
Shuttle and stabilize: H1.2-FUS complex in amyotrophic... : Neural Regeneration Research
An abstract is unavailable. This article is available as a PDF only.
journals.lww.com
💫NEW: @annaleder.bsky.social et al. show that the chaperones PDIA6, Hsp70 BiP, ERdj3, PDIA1 and Hsp90 form co-condensates within the endoplasmic reticulum, enhancing folding and preventing misfolding of client proteins. @masgu.bsky.social @hillerlab.bsky.social bit.ly/47b3Mjk
A multichaperone condensate enhances protein folding in the endoplasmic reticulum - Nature Cell Biology
Leder et al. show that the chaperones PDIA6, Hsp70 BiP, ERdj3, PDIA1 and Hsp90 form co-condensates within the endoplasmic reticulum, enhancing folding and preventing misfolding of client proteins.
bit.ly
Franziska Hommen did an excellent job in her thesis defense — we have a new PhD in the building! @cecad.bsky.social @cga-age.bsky.social
We have a 4-year postdoc position open in our Research Unit on proteostasis! The project explores inter-tissue regulation using advanced proteomics approaches. Collaborative & interdisciplinary environment. More details & application here: jobs-uk-koeln.onlyfy.jobs/job/pktg6ivj...
Postdoc Position (f/m/x)
We are looking to support our rapidly growing team as soon as possible:
jobs-uk-koeln.onlyfy.jobs
🧪#Celegans - I am very excited to announce the publication of our latest finding in transgenerational epigenetic inheritance (TEI) of learned pathogen avoidance - • C. elegans transgenerational avoidance of P. fluorescens is mediated by the Pfs1 sRNA and vab-1 www.science.org/doi/10.1126/...
C. elegans transgenerational avoidance of P. fluorescens is mediated by the Pfs1 sRNA and vab-1
C. elegans’ TEI of learned pathogen avoidance is induced by a third bacterial small RNA, Pfs1, from P. fluorescens 15.
science.org
Online now - a tribute to the memory of Prof. Joan J. Guinovart from Jordi Duran and Matthew Gentry. Prof. Guinovart was a renowned biochemist in the field of glycogen metabolism and known for his leadership in science. (1/4)
Thrilled to announce that our DFG Research Unit on cell-autonomous regulation of proteostasis has been approved for funding!
CECAD Scientists Receive DFG Funding for Proteostasis Research
A new DFG-funded research group investigates how proteostasis is regulated at the organismal level and its impact on aging and disease.
cecad.uni-koeln.de
CECAD Cologne@cecad.bsky.social · last yr.Congratulations to #CECAD Prof. David Vilchez @thevilchezlab.bsky.social on securing #DFG funding for a new research group on organismal proteostasis! This project, involving also Prof. Hoppe, will explore how proteostasis regulates #aging and #disease. @dfg.de #Proteostasis uni.koeln/ZCFFX
Excited to share our latest work! We asked if and how TDP-43 regulates RNA transport in neurons and if this is misregulated in ALS. We found that it works to keep RNAs *out* of neurites, and that loss of TDP-43 activity results in specific RNAs aberrantly accumulating there.
#NCB2024 In October, @toettch.bsky.social, McNamara & co reported that, in #gastruloids, cell sorting rearranges patchy domains of Wnt activity into a single pole, which defines the anterior–posterior axis. rdcu.be/d4vk5 www.nature.com/articles/s41...
Recording morphogen signals reveals mechanisms underlying gastruloid symmetry breaking
Nature Cell Biology - Toettcher, McNamara and colleagues use synthetic ‘signal-recording’ gene circuits on mouse gastruloids and find that cell sorting rearranges patchy domains of Wnt...
rdcu.be
I have no words to express how much I owe to Joan for his mentorship and advice. I became a professor thanks to his unwavering support. For instance, he insisted that I take English courses—and even paid for them—because I didn’t speak English while pursuing my PhD. I will miss you tons 😢😢
IRB Barcelona@irbbarcelona.org · 2y agoWith great sadness, we announce the passing of Dr. Joan Guinovart, founder, former scientist, director, and Emeritus Professor of IRB Barcelona. Our deepest condolences to his loved ones and the IRB Barcelona community. You will always be remembered, Captain.
Here is a brief summary of academic journals and news account. Please help me add more accounts to this list! go.bsky.app/hCfhqn
If your are having issues receiving strains from the CGC in Europe, this can really help,…Launch of the European Hub for CGC strain distribution community.alliancegenome.org/t/european-s...
European Shipping Hub
We are glad to announce the launch of the European Hub for CGC strain distribution. Since the pandemic, CGC shipments have become increasingly difficult to manage with higher costs, longer transit ti...
community.alliancegenome.org
We strongly suggest that academic publishers and other platforms that host research rapidly implement a Share to Bluesky button for their articles. Here's how: docs.bsky.app/docs/advance... #AcademicSky #HigherEd #Altmetrics
Action Intent Links | Bluesky
Authors, websites, and apps can use action intent links to implement "Share on Bluesky" buttons, or similar in-app actions. Logged-in users will be directed to the corresponding action view in the Blu...
docs.bsky.app
Bioart: a cool freeware alternative to Biorender bioart.niaid.nih.gov from the NIH
Bioart
bioart.niaid.nih.gov
New paper from the lab! ALS-FUS mutations cause abnormal PARylation and histone H1.2 interaction, leading to pathological changes: cell.com/cell-reports... #ALS
ALS-FUS mutations cause abnormal PARylation and histone H1.2 interaction, leading to pathological changes
Alirzayeva et al. find that ALS-related mutant FUS gains interaction with PARP1 and histone H1.2. Reducing either PARP1 activity or H1.2 levels prevents pathological changes in human motor neurons and...
cell.com
We’re happy to share our latest work by Gautier Langin on how the “ER-anchored protein sorting controls the fate of two proteasome activators for intracellular organelle communication during proteotoxic stress” #proteostasis ♻️ 🌱☀️ #PlantScience 🧵 (1/18) 🧵 www.biorxiv.org/content/10.1...
