Deeply honored to be elected as an EMBO member. This would not have been possible without the incredible past and present members of my lab - thank you for your dedication, creativity and total lack of fear over the years 🔬🪰🧪

MRC Laboratory of Molecular Biology@mrclmb.ac.uk · last mo.

Congratulations to LMB Group Leaders Emmanuel Derivery, Kelly Nguyen and Julian Sale, who have all been elected members of @EMBO.org! Read more about their research at the LMB here: mrclmb.ac.uk/news-events/... #LMBNews @deriverylab.bsky.social @kellythd-nguyen.bsky.social @juliansalelab.bsky.social

I am honoured to have received the Otto Hahn Medal! Thank you Jan @brugueslab.bsky.social, @ursa-ursic.bsky.social, Michael Staddon, @mpi-cbg.de, and @poldresden.bsky.social for your support during this scientific journey!

Brugues Lab@brugueslab.bsky.social · 2mo ago

It was an honor to introduce @alisonkickuth.bsky.social during the Otto Hahn medal ceremony from the @maxplanck.de in recognition for her amazing PhD, where she discovered a new mechanism for unilateral cytokinesis (www.nature.com/articles/s41...)

It was an absolute honour to win the #BSCB poster prize at #DynamicCellVI ! Its my first ever dynamic cell and I already can't wait for the next one! Make sure to come to our other talk today on using this tech to study endosomal dynamics?

Check out this preprint from the @simonbullock11.bsky.social lab, amazing work led by @lucas-albacete-x2.bsky.social ! 🔬

Simon Bullock@simonbullock11.bsky.social · 5mo ago

Delighted to announce the posting of our latest preprint, which links stress-induced relocalisation of multiple organelles by dynein to adaptive changes in gene expression in the nucleus (1/n) 🧵 www.biorxiv.org/content/10.6...

🚨🚨🚨Check out this new preprint from the Löwe lab proposing that microtubule architecture and dynamics evolved in Asgard archaea prior to eukaryogenesis! Happy to have had a little contribution by showing that Asgard tubulin displays a key hallmark of eukaryotic tubulins: dynamic instability! 🚨🚨🚨

Thijs J. G. Ettema 🦠🔬🇳🇱🇸🇪🇪🇺@ettema.bsky.social · 6mo ago

Our latest preprint: Together with the team of Jan Löwe, @danieltamarit.bsky.social and many others we discovered and characterized several Asgard tubulin genes and propose that microtubule architecture and dynamics evolved in Asgard archaea prior to eukaryogenesis www.biorxiv.org/content/10.6...

Steven has joined us as an RA to assist in the design, production and characterization of a panel of binders to be used as biosensors to image sorting of endogenous cargos in cells using multispectral microscopy, or as modulators of activities of sorting machineries! Welcome to the lab, Steven!

There’s just ONE WEEK left to apply to join our amazing PhD programme next year! Visit our website for more information: www2.mrc-lmb.cam.ac.uk/students/int... Applications close on 2nd DEC 2025

We present a simple method to easily increase the imageable depth of an expansion microscopy gel on a typical inverted microscope ten-fold, using some carefully placed FEP film and a water dipping objective lens:

bioRxiv Biophysics@biorxiv-biophys.bsky.social · 11mo ago

Maximising imaging volumes of expanded tissues for inverted fluorescence microscopy https://www.biorxiv.org/content/10.1101/2025.09.12.675899v1

The final version of our multispectral microscopy manuscript is now online at Nature Photonics: www.nature.com/articles/s41... The main additions are some further comparisons to yet more unmixing algorithms, in which we find that our algorithm is still the most accurate.

Multispectral live-cell imaging with uncompromised spatiotemporal resolution - Nature Photonics

A tree-like arrangement of dichroic mirrors and multiple cameras coupled with an iterative spectral unmixing algorithm enables multispectral imaging of live cells in up to eight spectral channels with...

nature.com

James Manton@jamesdmanton.bsky.social · 2y ago

We've recently updated our multispectral microscopy manuscript to clarify a few points (particularly regarding SNR) and add eight supplementary figures. Courtesy of Sjoerd Stallinga, we now also have a derivation of the appropriate Cramér–Rao lower bound! www.biorxiv.org/content/10.1...

We are very happy that the amazing PhD work of our previous PhD student, @akaashkumar.bsky.social is out in Nature Photonics!

Akaash Kumar@akaashkumar.bsky.social · 11mo ago

🚨Publication alert🚨 My first, first-author paper is now out in @natphoton.nature.com! Our paper describes an iterative spectral unmixing algorithm and eight-channel camera-based hardware we developed enabling unmixing of low SNR live-cell data at video rates. www.nature.com/articles/s41...

Great opportunity for a Research Support Officer to join @cellbiol-mrclmb.bsky.social, supporting @deriverylab.bsky.social in their studies of the molecular mechanisms behind receptor sorting in endosomes. More info: www.nature.com/naturecareer... Apply by 10 JUL #ScienceJobs

🚨 JOB ALERT 🚨 We're hiring a Research Assistant – no PhD needed! Join us to explore the molecular mechanisms of receptor sorting in endosomes. Experience in protein expression/purification, cloning & cell culture desired 🧫🔬 Apply now 👉 www.nature.com/naturecareer... #STEMCareers #ResearchJobs

Emmanuel Derivery (@deriverylab.bsky.social in @cellbiol-mrclmb.bsky.social) speaks to @jcellsci.bsky.social about the motivations behind his career, the exciting field of protein design & advice for new Group Leaders. Full interview: journals.biologists.com/jcs/article/... #LMBintheNews

In our latest interview, we hear from the 2024 @bscb-official.bsky.social Hooke Medal winner Emmanuel Derivery @deriverylab.bsky.social. Emmanuel tells us about his research, what winning the Hooke Medal means to him & his advice on building a successful lab. journals.biologists.com/jcs/article/...

😊 Very happy to see this out! A real group effort from the Hyslop lab (@thecimr.bsky.social) including brilliant collaborations with @knowleslab.bsky.social, Vendruscolo lab, @michael-e-ward.bsky.social lab, @deriverylab.bsky.social lab, @profmarciniak.bsky.social lab 🎉🎉🎉

ANXA11 biomolecular condensates facilitate protein-lipid phase coupling on lysosomal membranes - Nature Communications

Nixon-Abell et al. show that ANXA11 condensation on lysosomal membranes causes a coupled phase transition of the underlying lipids and mechanical stiffening of the overall ensemble involved in RNP gra...

nature.com

Are you an undergraduate student considering a career in academic research? Don’t miss the opportunity to gain hands-on experience at the LMB with our Student Placement Scheme – open now for applications! Apply by 30th March. More info: www2.mrc-lmb.cam.ac.uk/students/stu...

We are super proud of @lara-kruger.bsky.social who is leaving to start her own lab at @institutcurie.bsky.social - you're going to be missed in the Derivery lab!

MRC Laboratory of Molecular Biology@mrclmb.ac.uk · last yr.

Congratulations to @lara-kruger.bsky.social, postdoc in @deriverylab.bsky.social in @cellbiol-mrclmb.bsky.social, who is leaving the LMB to establish her own research group at @institutcurie.bsky.social in Paris! Best of luck to you Lara! #LMBAlumni

Our automatic parameter-free deconvolution code is now 2–3× faster while still producing exactly the same results as before. If you want to try it out, we have a Google Notebook implementation available at beryl.mrc-lmb.cam.ac.uk/rlgc_notebook/. Manuscript WIP.

Congrats to @juliemiesch.bsky.social who was awarded a Postdoc Mobility grant by @snf-ch.bsky.social to support her research for two years. Her postdoc research will focus on the biophysical regulation of water buffering in the cell.

How does tRNA-modifier #Elongator stabilize microtubules during asymmetric cell division? Vicente Planelles Herrero @deriverylab.bsky.social et al find subcomplexes binding to microtubule ends & tubulin dimers, & enriching microtubules with polyglutamylated tubulin www.embopress.org/doi/full/10....

🚨 Paper Alert 🚨 Our preprint describing Elongator as a selective microtubule polymerase that rewrites PTMs on microtubules is now published! Check it out: www.embopress.org/doi/full/10....

Elongator is a microtubule polymerase selective for polyglutamylated tubulin | The EMBO Journal

imageimageElongator, an established tRNA-modifying complex, can also stabilize microtubules during asymmetric cell division. This study shows that Elongator subcomplexes achieve this by binding to mic...

embopress.org

Congrats to @akaashkumar.bsky.social who has won the PhD Award from the Cambridge Centre for Physical Biology for his work developing a novel microscopy system with @deriverylab.bsky.social & @jamesdmanton.bsky.social in @cellbiol-mrclmb.bsky.social. www.physbiol.cam.ac.uk/akaash-kumar #LMBintheNews

Congrats to @akaashkumar.bsky.social , a postdoc in the lab, for winning the PhD Award from the Cambridge Centre for Physical Biology. His PhD research worked on the development of a multispectral imaging system to image up to 8 fluorophores similtaneously for tackling complex biological questions!

Catching the blue-world up with the last 6 months of Derivery group shenanigans: First up: in April Manu was the recipient of the 2024 Hooke Medal from BSCB!

We are excited to be over here on BlueSky! @DeriveryLab on the other app.

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ALT: a white cat is laying on its back on the floor and says `` hello . hello ... ''

media.tenor.com