Eric Denovellis

@eric-denovellis.bsky.social

Computational Neuroscience Research Scientist @UCSF Frank Lab https://www.edenovellis.com/ https://github.com/edeno

New Annual Review with @nathanieldaw.bsky.social: “Planning in the Brain: It's Not What You Think It Is.” We argue that the brain's 'planning' machinery is mostly used for learning from simulated experience, and that thinking prospectively at decision time is just one special case of this process.

Planning in the Brain: It's Not What You Think It Is

The neuroscience of planning has long been analogized to search algorithms in artificial intelligence (AI), which simulate future actions to guide immediate choices. We argue that advances in both neu...

annualreviews.org

Great papers in spatial neuro this week. Csicsvari's group: hippocampal place fields stabilise during learning while mPFC stays flexible. Giocomo's lab: CA1-subiculum topography actively shapes boundary coding & corner cells. doi.org/10.64898/2026.03.27.714523 doi.org/10.64898/2026.03.24.714092

The hippocampal map has its own attentional control signal! Our new study reveals that theta #sweeps can be instantly biased towards behaviourally relevant locations. See 📹 in post 4/6 and preprint here 👉 www.biorxiv.org/content/10.6... 🧵(1/6)

Attention-like regulation of theta sweeps in the brain's spatial navigation circuit

Spatial attention supports navigation by prioritizing information from selected locations. A candidate neural mechanism is provided by theta-paced sweeps in grid- and place-cell population activity, which sample nearby space in a left-right-alternating pattern coordinated by parasubicular direction signals. During exploration, this alternation promotes uniform spatial coverage, but whether sweeps can be flexibly tuned to locations of particular interest remains unclear. Using large-scale Neuropixels recordings in freely-behaving rats, we show that sweeps and direction signals are rapidly and dynamically modulated: they track moving targets during pursuit, precede orienting responses during immobility, and reverse during backward locomotion — without prior spatial learning. Similar modulation occurs during REM sleep. Canonical head-direction signals remain head-aligned. These findings identify sweeps as a flexible, attention-like mechanism for selectively sampling allocentric cognitive maps. ### Competing Interest Statement The authors have declared no competing interest. European Research Council, Synergy Grant 951319 (EIM) The Research Council of Norway, Centre of Neural Computation 223262 (EIM, MBM), Centre for Algorithms in the Cortex 332640 (EIM, MBM), National Infrastructure grant (NORBRAIN, 295721 and 350201) The Kavli Foundation, https://ror.org/00kztt736 Ministry of Science and Education, Norway (EIM, MBM) Faculty of Medicine and Health Sciences; NTNU, Norway (AZV)

biorxiv.org

Alex Pretti was already restrained when federal agents shot and killed him in Minneapolis, a New York Times analysis of video shows. The footage contradicts the Department of Homeland Security’s account of the shooting.

Timeline: How the Shooting of Alex Jeffrey Pretti Unfolded

A moment-by-moment analysis of video from the scene shows that Mr. Pretti was already restrained when fatal shots were fired, which appears to contradict the federal government’s account of the event.

trib.al

Introducing a new scientific computing library: syntropy. Syntropy is a comprehensive package for information theory, aimed at both theoreticians and data analysts working on discrete, continuous, and mixed data. 1/N github.com/thosvarley/s...

GitHub - thosvarley/syntropy: A python package for information-theoretic analysis of discrete and continuous data.

A python package for information-theoretic analysis of discrete and continuous data. - thosvarley/syntropy

github.com

📣 Pre-COSYNE Brainhack 2026 – Join Us in Lisbon! 🧠✨ March 10–11, 2026 • Lisbon, Portugal pre-cosyne-brainhack.github.io/hackathon2026 Kick off COSYNE week with two days of hands-on, team-based hacking around real electrophysiology data! ✅ Apply now via the event website (limited spots).

🎉 NeuroConv 0.9.0 is out! This release brings: ✅ Redesigned TIFF converter for multi-file & volumetric data ✅ Enhanced Miniscope support with auto-aggregation ✅ NWB file repacking for better compression ✅ New behavioral data documentation Read more: catalystneuro.com/blog/neuroco...

CatalystNeuro - Neurophysiology Data & Software Solutions

CatalystNeuro empowers neuroscience labs with data standardization, NWB conversions, spike sorting pipelines, and open-source software tools.

catalystneuro.com

Check out our new perspective paper in eNeuro! We explore recent advancements and future prospects in open neuroscience, and discuss how open science practices, data sharing, and structural changes can create a more collaborative and transparent scientific ecosystem www.eneuro.org/content/12/1...

Open Data In Neurophysiology: Advancements, Solutions & Challenges

Ongoing efforts over the last 50 years have made data and methods more reproducible and transparent across the life sciences. This openness has led to transformative insights and vastly accelerated sc...

eneuro.org