Erica Dinatale
@ericadinatale.bsky.social
Doctoral researcher @mpi-bio-fml.bsky.social and curious human being De-coding brown algae 🍙
DIAMOND DeepClust: an ultrafast clustering method for organizing the protein universe of life. www.nature.com/articles/s41...
Clustering the protein universe of life using DIAMOND DeepClust - Nature Methods
DIAMOND DeepClust provides an ultra-fast clustering method for organizing the protein universe of life at low sequence identity, enabling large-scale dimensionality reduction and improving downstream ...
nature.com
Out now in @newphyt.bsky.social with @joannarifkin.bsky.social, @jotlovell.bsky.social, @spicybotrytis.bsky.social & more! Our high-quality pennycress pangenome is a striking example of genome architecture shaping different kinds of genomic variation, including some surprising centromeric movement
Structure and sequence evolution in the pennycress (Thlaspi arvense) pangenome
Eukaryotic genomes harbor many forms of variation, including nucleotide diversity and structural polymorphisms, which experience natural selection and contribute to genome evolution and biodiversity...
doi.org
A good read on a large virus... Extensive array of endogenous giant viral elements in a polar alga shows dynamic transcriptional response to abiotic stress: Current Biology www.cell.com/current-biol...
Extensive array of endogenous giant viral elements in a polar alga shows dynamic transcriptional response to abiotic stress
Schultz et al. show that polar algae harbor extensive endogenous giant virus elements that are transcriptionally active, stress responsive, and integrated into host regulatory networks, highlighting v...
cell.com
Now out! We show that TEs can be horizontally transferred between fungal species via Starships. Once transferred, these TEs can become active, changing the genome organization and affecting the lifestyle of the recipient fungus. www.nature.com/articles/s41... @oggenfussursula.bsky.social #TEsky
Transposable elements hitchhike on Starships across fungal genomes - Nature Communications
Large mobile genetic elements known as Starships act as vehicles for transferring transposable elements (TEs) between fungi. Here, Griem-Krey et al. show that these ‘hitchhiking’ TEs can drive rapid e...
nature.com
Happy to share the results of a long-haul post-doc project, now online @science.org, aiming at understanding the rules of transgeneration epigenetic inheritance over TEs in plants and its extent and impact in nature. More below! doi.org/10.1126/scie...
Transposable elements are vectors of recurrent transgenerational epigenetic inheritance
DNA methylation loss at transposable elements (TEs) can affect neighboring genes and be epigenetically inherited in plants, yet the determinants and significance of this additional system of inheritan...
doi.org
TEs aren’t just genomic parasites, they’re also engines of genomic novelty. Our new study with ~2,000 Z. tritici genomes shows repeated TE mobilization waves during global expansion. With @danielcroll.bsky.social & @guidopuccetti.bsky.social 🧬 www.nature.com/articles/s41... #TEworldwide
Historic transposon mobilisation waves create distinct pools of adaptive variants in a major crop pathogen - Nature Communications
In this study, the authors analysed a large genomic dataset to trace how jumping genes shaped the global spread of a major wheat pathogen and reveal bursts of activity over decades that drove adaptati...
nature.com
Out today, our take on 6-methyladenine #6mA evolution in Eukaryotes @natgenet.nature.com. We asked a simple question, is really DNA 6mA common across the eukaryotes? The answer is "yes" if you're a unicellular eukaryote 🦠, not so if you're multicellular 🐝🌱🍄. www.nature.com/articles/s41... 1/9
Adenine DNA methylation associated with transcriptionally permissive chromatin is widespread across eukaryotes - Nature Genetics
Long-read sequencing in 18 unicellular eukaryotes reveals that 6mA is widespread across eukaryotes and is enriched at transcriptionally permissive regions, which are also marked by H3K4me3.
nature.com
Our work on chromatin evolution in brown algae is finally out! This is also my first "co-first author" paper!! I’m excited to share what we found 👇
Nature Ecology & Evolution@natecoevo.nature.com · 4mo agoChromatin plays a central role in gene regulation, but chromatin systems are only known for a few model species. This study analyses chromatin regulatory landscapes in brown algal lineages to elucidate their structural organization and evolution 🧪 www.nature.com/articles/s41...
Does hidden protein biology live in the suboptimal alignment space? When we align two divergent proteins, we usually trust a single optimal alignment. 🧬 But what if the real structural signal lies in the space of near-optimal solutions? With EMERALD-UI you can unfold this perspective.
📣 Meet the new ERC Synergy Grant awardees! Sixty-six research teams have been selected for funding, bringing together 239 scientists. Congratulations to all! ➡️ buff.ly/PSn3bi9 #EUfunded #HorizonEurope #ERCSyG
This Halloween, we have a spooky evolutionary story for you. The brainchild of @delaconcepcionjc.bsky.social, Nick Irwin and our fantastic collaborators is now out in @natplants.nature.com www.nature.com/articles/s41... Here’s why I love this work — and why I think you’ll enjoy it too. 👇
#TEsky A comparative analysis of transposable element diversity and evolution across 75 bee genomes doi.org/10.1186/s128...
A comparative analysis of transposable element diversity and evolution across 75 bee genomes - BMC Genomics
Transposable elements (TEs) are repetitive DNA sequences that can alter their position and abundance within genomes. While TEs are known to have various impacts on genome structure and function, our u...
doi.org
1/ Ever needed to annotate TEs in a fungal genome, but didn't know where to start? We have released #MycoMobilome, a community-focused non-redundant database of transposable element consensus sequences for the fungal kingdom, constructed from >4,000 fungal genomes! www.biorxiv.org/content/10.1...
Very happy to see our paper published online natcomms.nature.com. Thank you to @wellcometrust.bsky.social for funding this work during my time with @robklose.bsky.social and David Booth! Thanks also to collaborators @garcialabms.bsky.social @alexdemendoza.bsky.social and the other authors!
Chromatin profiling identifies putative dual roles for H3K27me3 in regulating cell type-specific genes and transposable elements in choanoflagellates
Nature Communications - Here, the authors investigate chromatin-based gene regulation in the closest relative of animal, choanoflagellates. They uncover a putative dual role for the histone...
rdcu.be
Excited to introduce Auxenochlorella as a new algal reference organism for fundamental plant science and bioengineering. A paper in two parts: a genetic toolkit for site-specific genomic manipulation, paired with the most unusual genome I’ve ever worked on academic.oup.com/plcell/artic...
Targeted genetic manipulation and yeast-like evolutionary genomics in the green alga Auxenochlorella
Auxenochlorella, green algae shaped by evolutionary forces acting on vegetative diploids, are amenable to discovery research and bioengineering via efficie
academic.oup.com
1/9 New in @science.org www.science.org/doi/10.1126/science.ado8005 How does genetic architecture constrain evolutionary trajectories? To address this question, we inferred the genetic architecture of convergent plumage coloration and its evolutionary history in wheatears.
A mosaic of modular variation at a single gene underpins convergent plumage coloration
The reshuffling of genomic variation from multiple origins is an important contributor to phenotypic diversification, yet insights into the evolutionary trajectories of this combinatorial process and ...
science.org
3/9 The black-or-white throat polymorphism is explained by the interaction of a transposable element (an LTR retrotransposon) upstream ASIP with ASIP coding variation. Mantle and neck side coloration is encoded by additive effects of regulatory variants upstream ASIP.
We discovered an endogenous retrovirus that's still spreading in natural D. melanogaster populations! It was horizontally transferred from D. erecta in Central Africa, so we named it "Kuruka", which means "jump" in Swahili. Read its cool story here: www.biorxiv.org/content/10.1...
Thrilled to share what we learned from re-annotating the mobilome of the brown algae model [Ectocarpus] 🌊🌿🏖️ genomebiology.biomedcentral.com/articles/10.... A wonderful collaboration with @ericadinatale.bsky.social, @cssmartinho.bsky.social, @rorycraig.bsky.social, and Susana Coelho! 🎉
It would be exciting to study whether there are clear "causal" links between TE regulation and body plan formation in brown algae, where 'artificial' mobilisation of young TEs can drive innovation (and overcome constraints) in the formation of multicellular phenotypes.
So happy to see my first first-author paper published! 🎈 A short thread on how Ectocarpus and its TE secrets have kept me busy lately: rdcu.be/eITQH
Characterization of the transposable element landscape shaping the Ectocarpus genome | Genome Biology
rdcu.be
New research: With ancient origins & surprising flexibility, #BrownAlgae reveal a compelling story of sex chromosome evolution. This could rewrite how we view sex determination. Learn more: s.gwdg.de/YDoZ3L Congrats to @agalip.bsky.social & Josue Barrera for their work in @natecoevo.nature.com
Nature Ecology & Evolution@natecoevo.nature.com · 12mo agoGenomes of brown algae with different sex determination systems show that U/V sex chromosomes evolved 450–224 million years ago and show remarkable conservation of genes within the sex-determining region, despite independent expansions of the sex locus in each lineage www.nature.com/articles/s41...
Genomes of brown algae with different sex determination systems show that U/V sex chromosomes evolved 450–224 million years ago and show remarkable conservation of genes within the sex-determining region, despite independent expansions of the sex locus in each lineage www.nature.com/articles/s41...
Origin and evolutionary trajectories of brown algal sex chromosomes - Nature Ecology & Evolution
Genomes of nine brown algal species with different sex determination systems show that U/V sex chromosomes evolved 450–224 Ma and show remarkable conservation of genes within the sex-determining regio...
nature.com
Free online ebook: R and python comparisons side by side www.anotherbookondatascience.com/chapter1.html
Delighted to share the peer-reviewed version of our study led by @tomlewin.bsky.social now out in Genome Biology @bmc.springernature.com! We analyzed 64 chromosome-level genomes across 15 animal phyla and found that extensive genome rearrangements are the norm in bilaterians. doi.org/10.1186/s130...
Conservation of bilaterian genome structure is the exception, not the rule - Genome Biology
Species from diverse animal lineages have conserved groups of orthologous genes together on the same chromosome for over half a billion years since the last common ancestor of bilaterians. Although no...
doi.org
💥🥳 At long last, our latest paper is out! Gag proteins of endogenous retroviruses are required for zebrafish development www.pnas.org/doi/10.1073/... Led heroically by Sylvia Chang & @jonowells.bsky.social A study which has changed the way I think of #transposons! No less! 🧵 1/n
Gag proteins encoded by endogenous retroviruses are required for zebrafish development | PNAS
Transposable elements (TEs) make up the bulk of eukaryotic genomes and examples abound of TE-derived sequences repurposed for organismal function. ...
pnas.org
Transposable elements in brown algae? 🌊 Yes, they’re full of surprises ✨ Come meet Ectocarpus at #ESEB2025! 📍Room 113 - S28.03 🗓️ Thursday, 2:30pm
#ESEB2025 check out poster 221! The amazing work of @petrollromy.bsky.social and @borglab.bsky.social is also here ⤵️ www.cell.com/current-biol...
The expanded Bostrychia moritziana genome unveils evolution in the most diverse and complex order of red algae
Petroll et al. present a chromosome-level genome assembly of Bostrychia moritziana to illuminate evolution of the most complex and diverse order of red algae. Unexpected novelties include genome expan...
cell.com
Romy Petroll@petrollromy.bsky.social · 12mo agoSo excited to be at #ESEB2025 presenting poster 221 today!☀️ Check out our chromosome-level genome of Bostrychia, a red alga from the complex Ceramiales order, revealing massive genome expansion by giant Plavaka DNA transposons, the evolution of expanded gene families and UV sex chromosomes!
