New work from our lab @faurelab.bsky.social expending the tools available to study nicotinic receptors more precisely. @espciparispsl.bsky.social @psl-univ.bsky.social

Institut Pasteur | 130 years of biomedical research@pasteur.fr · 2w ago

Institut Pasteur researchers developed "optonanobody": a light-controlled nanobody targeting α7 nicotinic receptors. Switch receptors on/off with light, no genetic editing needed. New research tool for Alzheimer's, Parkinson's & schizophrenia. #Neuroscience ↘️ pubs.acs.org/doi/10.1021/...

Our new study on neurobiology of stress-driven food intake. www.nature.com/articles/s41... In mice, PFC controls lateral hypothalamus through a multi-branched network. Stress causes differential plasticity across branches, priming the network to promote bingeing. #stresseating

New paper in Nature, @nature.com (go.nature.com/4c4OjCj) : how do social roles emerge in groups of near-identical individuals ? we find that they are neither predetermined nor fixed.

Dopaminergic mechanisms of dynamical social specialization - Nature

Longitudinal tracking of mice reveals that stable, specialized social roles emerge spontaneously within groups during a foraging task, with dopaminergic activity in the ventral tegmental area driving ...

go.nature.com

1/4 When rules change, dopamine (DA) changes what it calls an “action”. New bioRxiv version: “Dopamine tracks adaptive learning of action representations”. www.biorxiv.org/content/10.1... This project brought together Maxime Come’s PhD work and Arnaud Lespart’s postdoctoral work in our lab.

Congratulations Lauren

CNRS Biologie@cnrsbiologie.bsky.social · 7mo ago

@laurenmac.bsky.social, chercheuse en neurosciences au laboratoire Plasticité du cerveau est lauréate du Prix Bernard Bioulac 2025. 👋 @cnrs-paris.bsky.social @espciparispsl.bsky.social @faurelab.bsky.social www.youtube.com/watch?v=yneN...

⚠️ New paper alert and what a way to end 2025! 🎉 Happy to share our story “Sleep-dependent infraslow rhythms are evolutionarily conserved across reptiles and mammals.” published today in Nature Neuroscience. Sleeping dragons 🦎 and functional ultrasound! Read the full paper here: rdcu.be/eWJHb 1/8

Sleep-dependent infraslow rhythms are evolutionarily conserved across reptiles and mammals

Nature Neuroscience - Bergel et al. show that an infraslow rhythm connecting the brain and body during sleep is shared by lizards, mammals and birds, revealing an ancestral process and reshaping...

rdcu.be

Congrats, well deserve

Antoine Bergel@antbergel.bsky.social · 8mo ago

Huge thanks to all my mentors over the years for their time, help, and advice. In particular @mickaeltanter.bsky.social, @apeyrache.bsky.social, K. Benchenane and @faurelab.bsky.social. Very grateful 🙏.

You just finished your PhD and you are looking for a postdoc to study stress-dependent modulation of learning. We are using the powerful fly model to understand the underlying circuits and mechanisms. You can apply here: emploi.cnrs.fr/Offres/CDD/U...

Big news for @laurenmac.bsky.social ! 2025 is quite a year: CNRS position + ERC Starting Grant Her project DeMARRe will study how adolescent exploration & risk-taking shape neural circuits and resilience in adulthood. @cnrs.fr @espciparispsl.bsky.social www.insb.cnrs.fr/fr/personne/...

Lauren Reynolds

insb.cnrs.fr

1 To predict the behaviour of a primate, would you rather base your guess on a closely related species or one with a similar brain shape? We looked at brains & behaviours of 70 species, you’ll be surprised! 🧵Thread on our new preprint with @r3rt0.bsky.social , doi.org/10.1101/2025...

Alcool et nicotine : un même circuit cérébral à l’origine de la récompense et de l’anxiété 👋 @cnrs-paris.bsky.social @espciparispsl.bsky.social ✍️ @faurelab.bsky.social & Fabio Marti 👉 Lire l'article dans buff.ly/vE1j6LP buff.ly/fD5DOxu

Nicotine doesn’t just “turn on” the brain’s reward circuits — it reshapes them. Our new paper in Nature Communications shows that activating reward-linked dopamine neurons also sets off a feedback loop that drives negative emotional states. www.nature.com/articles/s41...

Nicotine engages a VTA-NAc feedback loop to inhibit amygdala-projecting dopamine neurons and induce anxiety-like behaviors - Nature Communications

Drugs of abuse exert both motivational and emotional effects. Here, the authors show that nicotine and ethanol activate a VTA–NAc loop that inhibits dopamine neurons projecting to the amygdala, thereb...

nature.com

Our work on the role of the interpeduncular nucleus in nicotine reward ( www.cell.com/neuron/abstr... ) is featured in a Neuron Preview ! Brandon J Henderson highlights how a new regulatory circuit controlling nicotine reinforcement has been uncovered. www.cell.com/neuron/abstr...

Slowing the drive: A new regulatory break for nicotine reward-related behaviors

In this issue of Neuron, Jehl et al. developed a “suicide” antagonist to demonstrate that the interpeduncular nucleus acts as a regulatory controller of nicotine reward-related behavior through connec...

cell.com

Yesss! So happy to see this, totally deserved!

Lauren Reynolds@laurenmac.bsky.social · last yr.

Thrilled to share that I have obtained a permanent position at CNRS 🎉🎉🎉 Thanks so much to everyone that supported me along the way, and especially @faurelab.bsky.social !

Our work on rubber hand embodiment in mice is out @plosbiology.org! We show that just like in humans, visuo-tactile pairing can lead mice to an embodiment-like behavior with respect to an artificial limb.

Embodiment of an artificial limb in mice

Body ownership disorders can be triggered by disease or body damage in humans. This study shows, using an automated, videography-based procedure, that mice also display quantifiable behavioral markers...

journals.plos.org

Nouvel article avec mes ami-es belges E. Chaves et A. de Kerchove où on décrit l'effet de l'activation de populations de neurones du striatum sur les stratégies de décision. On a essayé de sortir d'une définition "par l'expérimentateur" de la performance des souris. www.science.org/doi/10.1126/...

Direct and indirect striatal projecting neurons exert strategy-dependent effects on decision-making

In the dorsomedial striatum, d-SPNs increase risk seeking, while iSPNs amplify the value of large gains in decision making.

science.org

Hot off the press: The excellent Maheva Andriatsilavo and colleagues show how a temporal sequence of stochastic molecular mechanisms allow the emergence of stereotyped individualised neuronal circuits. Just published in Nature Neuroscience: rdcu.be/ek010

Sequential and independent probabilistic events regulate differential axon targeting during development in Drosophila melanogaster

Nature Neuroscience - The developmental origin of behavioral individuality is unclear. The authors show that a temporal sequence of genetically encoded stochastic mechanisms explains variation in...

rdcu.be

I have an opening in my lab for a postdoctoral fellow to work on projects that relate to the mechanisms of neurotransmitter release by dopamine neurons and/or on how inflammatory signals infuence the functionning of these neurons. Please share.

The interpeduncular nucleus (IPN) dampens nicotine reward via β4* nAChRs and IPN→LDTg projections. Blocking this pathway enhances VTA responses and CPP: A nicotine-specific brake embedded in the mesolimbic system. New paper from the lab out in @cp-neuron.bsky.social www.cell.com/neuron/abstr...

The interpeduncular nucleus blunts the rewarding effect of nicotine

Nicotine activates the dopamine reward system to promote consumption and addiction, but the brain has a natural brake to counteract it. Jehl, Ciscato, Vicq, Guyon, et al. identified the interpeduncula...

cell.com

Registrations for the Symposium for the Biology of decision making (SBDM) in Lyon 2025 are finally open! sbdm2025.github.io Please spread the message!

New preprint from the lab and @clementsolie.bsky.social on social organization & neuromodulation! Read the full preprint here: www.biorxiv.org/content/10.1... @espciparispsl.bsky.social @cnrsbiologie.bsky.social

Dopaminergic mechanisms of dynamical social specialization in mouse microsocieties

Social organization and division of labor are fundamental to animal societies, but how do these structures emerge from individual interactions, and what role does neuromodulation play in shaping them?...

biorxiv.org

This is one of my favourite papers for a while. Theoretically informed, technically accomplished, well-written and argued, articulates explanation 👏 By @jeremie-n.bsky.social and colleagues. I would love to teach it but it may be a lot... www.nature.com/articles/s41...

Dopamine builds and reveals reward-associated latent behavioral attractors - Nature Communications

The reason why manipulating dopamine (DA) activity can affect both action latency, action direction, and movement vigor, but only in certain animal states and behavioral settings is not fully understo...

nature.com

Superb study from Thomas Preat's team here @espciparispsl.bsky.social @cnrsbiologie.bsky.social , showing that astrocytes use redox H₂O₂ signaling to support memory in Drosophila. Amyloid-β disrupts this process, linking it to cognitive deficits in Alzheimer’s. www.nature.com/articles/s42...

Astrocyte-to-neuron H2O2 signalling supports long-term memory formation in Drosophila and is impaired in an Alzheimer’s disease model - Nature Metabolism

Rabah et al. discover an astrocyte-to-neuron hydrogen peroxide signalling cascade, which is crucial for long-term memory formation in Drosophila. This signalling is found to be inhibited by amyloid-β ...

nature.com

#RésultatScientifique🔎Comment la dopamine peut-elle orchestrer à la fois l’apprentissage et la motivation ? @jeremie-n.bsky.social propose une réponse à cette question dans @naturecomms.bsky.social ⤵️ 🤝 @cnrsoccitanieest.bsky.social @umontpellier.bsky.social @cnrsinformatics.bsky.social

De l’apprentissage à l’action : la dopamine révèle nos apprentissages cachés

La dopamine, une molécule clé dans le cerveau, est essentielle à l’

buff.ly

🚨 !!! Postdoc Position Available !!! 🚨 Join our team at the Neuromodulation Institute (Hôpital St-Anne) in Paris, France. Work on cutting-edge research involving voltammetric recordings in human patients and machine learning. 🧠🟦 / 🧠🤖 / 🧠🩺 #AcademicSky #postdoc

"Dopamine builds and reveals reward-associated latent behavioral attractors". This study combines computational modeling and experimental work to reveal how DA not only teaches, but also motivates, i.e by creating and using pathways toward goals. www.nature.com/articles/s41...

Dopamine builds and reveals reward-associated latent behavioral attractors - Nature Communications

The reason why manipulating dopamine (DA) activity can affect both action latency, action direction, and movement vigor, but only in certain animal states and behavioral settings is not fully understo...

nature.com

Paper from my PD with @faurelab.bsky.social came out a couple weeks ago #neuroskyence #neuroscience www.nature.com/articles/s41...

Transient nicotine exposure in early adolescent male mice freezes their dopamine circuits in an immature state - Nature Communications

How nicotine impacts the adolescent development of neural circuitry is not fully understood. Here authors show that early adolescent nicotine exposure in male mice blocked the maturation of nicotine-e...

nature.com

Adolescence is a critical period for nicotine addiction. We found that early nicotine exposure "freezes” dopamine circuits in an immature state, leading to lifelong vulnerability. Details can be checked in new Lab preprint www.biorxiv.org/content/10.1... - Congrats @laurenmac.bsky.social