This article in Le Monde about French research in general and the CNRS in particular has a few depressing graphs www.lemonde.fr/sciences/art...
Philippe Domenech
@philippedomenech.bsky.social
Computational neuroscientist and Full Prof in Psychiatry @ University of Paris, Head of Neuromodulation Institute at GHU Paris, Psychiatry Neurosciences
Every senator who voted to confirm RFK Jr owns this tragedy. Every single one.
Using 7T fMRI, our team found a representation of the probability of the next event in human dlPFC —and it’s highly non-monotonic. Confidence signals, in contrast, were mostly monotonic. doi.org/10.1038/s414... 🧠🟦🧠🤖
Thank you Nicole! Nicole's wonderful book 'Elusive Cures' has played an important role in pushing me out of my comfort zone and join forces w/ @philippedomenech.bsky.social and @bellecguill.bsky.social, here. Exciting times ahead for neuroscience. Go read it, if you haven't yet!
Nicole Rust@nicolecrust.bsky.social · 6mo agoExciting! A project that taps into the genius of this era on multiple levels - dynamical systems, machine learning / RL, brain computer interfaces in a terrific group. And bonus: it's in Paris 💙.
Using calcium imaging in macaque PFC during a meta–WM task, we show that PFC jointly encodes remembered locations + uncertainty. PFC integrates WM strength + cues into a meta-WM signal that guides behavior. A collab btw our team and Liping Wang group doi.org/10.1016/j.ne... 🧠🟦🧠🤖
Postdoc position in Paris: come help develop new generation human brain computer interfaces ⚡🧠💻 Interested? Contact me if you have experience with machine learning (e.g. simulation-based inference, RL, generative/diffusion models) or dynamical systems. See below for + details and retweet 🙏
🚨 !!! New preprint !!! 🚨 MULTIMODHAL (phase 3, multicenter double-blind RCT): fMRI “symptom-capture”–guided neuronavigation significantly improves 1-Hz rTMS outcomes for drug-resistant auditory verbal hallucinations vs standard T3P3 targeting. 🧠🟦 #rTMS #Psychiatry #Schizophrenia #fMRI
medrxiv.org
Tuberculosis still kills around 1.3 million people every year. It was once a massive killer in Europe and the US, but not anymore. How did these countries manage to tackle it? Our first article on TB in a three-part series: ourworldindata.org/tuberculosis...
Les visas des chercheurs, des universitaires et des étudiants pour les Etats-Unis ne seront pas accordés à celles et ceux qui ont exprimé de l'hostilité au régime autoritaire de Trump. Ces refus de visa se feront par analyse des posts sur les réseaux sociaux. www.nytimes.com/2025/06/18/u...
U.S. to Review Social Media Posts of Student and Scholar Visa Applicants
nytimes.com
www.lemonde.fr/economie/art...
Derrière la grave pénurie française de médicaments psychotropes, une défaillance industrielle
Plus de la moitié des pharmacies disposent de moins d’un jour de stock de traitements-clés pour les personnes bipolaires ou en dépression. L’arrêt à l’automne 2024 d’une usine grecque qui fabrique, po...
lemonde.fr
This is fantastic, causal work demonstrating the basal ganglia’s role in explore-exploit decision making www.nature.com/articles/s41...
Basal ganglia deep brain stimulation restores cognitive flexibility and exploration-exploitation balance disrupted by NMDA-R antagonism - Nature Communications
Deep brain stimulation of the basal ganglia restores cognitive flexibility and rebalances exploration disrupted by NMDA receptor antagonism in nonhuman primates, offering insights into the neural basi...
nature.com
Year ago, the prevailing attitude was that deep learning would significantly improve polygenic risk scores (or anything else, to be fair). A rather important set of negative results indicating that isn't the case (though I imagine many will still try). nature.com/articles/s41...
New in Nature MentalHealth! with Vrizzi, Najar, Lemogne, and @mael-lebreton.bsky.social We tested whether behavioural and RL-based model parameters are test-retest reliable and predict mental health traits. The result? Not really. A cautionary tale for comp. psychiatry doi.org/10.1038/s442...
Behavioral, computational and self-reported measures of reward and punishment sensitivity as predictors of mental health characteristics - Nature Mental Health
Reinforcement learning task-based behavioral and computational measures displayed low test–retest reliability at the individual level. Also in contrast to self-assessed personality measures, behaviora...
doi.org
New paper in Imaging Neuroscience by Britta U. Westner, Tim M. Tierney, et al: Cycling on the Freeway: The perilous state of open-source neuroscience software doi.org/10.1162/imag...
#OTD 1920 Edward Kaplan b (d 26 Sep 2006) Best known for 1958 "sleeper hit" paper describing what is now known as the Kaplan–Meier product-limit statistic for survival & lifetime data. Now one of the most cited statistics papers of modern times, it took >12 yrs to catch on. 🧵/6
$500 million is… less than 1.25% of the NIH’s 2024 budget. When I say there is no capacity to absorb the shock, I mean it.
Ursula von der Leyen@vonderleyen.ec.europa.eu · last yr.We will put forward a 500 million package for 2025-2027 to make Europe a magnet for researchers. As well as ambitious proposals for R&I in the next EU budget. We will also offer the best and brightest the right incentives to come to Europe ↓
Breaking News: A federal prosecutor interrogated the The New England Journal of Medicine — which is considered the world’s most prestigious medical journal — in what its editor described as a “vaguely threatening” letter.
‘Vaguely Threatening’: Federal Prosecutor Queries Leading Medical Journal
The New England Journal of Medicine received a letter suggesting that it was biased and compromised by external pressure. Other journals have also received the letter.
nytimes.com
New study in JAMA. Modelling shows that at current state-level vaccination rates, measles may become endemic again in the USA. If rates continue to decline, ditto for rubella, poliomyelitis and diphtheria, leading to many preventable hospitalisations and deaths. jamanetwork.com/journals/jam...
Modeling Reemergence of Vaccine-Eliminated Infectious Diseases Under Declining Vaccination in the US
This study estimates the number of cases and complications in the US under scenarios of declining childhood vaccination for measles, rubella, poliomyelitis, and diphtheria.
jamanetwork.com
Thrilled to share our state-of-the-art method for in vivo cell-type classification and brain region localization, NEMO, which is now now a spotlight at @iclr-conf.bsky.social ! We use NEMO to characterize the electrophysiological diversity of cell-types across the entire mouse brain. 🐭 🧪 🧠
Such a dangerous idea. US attorney demands scientific journal explain how it ensures 'viewpoint diversity' www.nbcnews.com/science/scie... Process of science – a human endeavour – full of biases. Key to recognize & counter. But can’t let false balance & middle ground fallacies taint research.
U.S. attorney demands scientific journal explain how it ensures 'viewpoint diversity'
The unusual letter caught the attention of First Amendment groups and some scientists, who raised concerns it was designed to suppress academic and scientific freedom.
nbcnews.com
Trump proposes massive NIH budget cut and reorganization www.science.org/content/arti...
Trump proposes massive NIH budget cut and reorganization
Will Republican-led Congress support a 44% decrease for world’s largest medical research funder?
science.org
The world now has a plan for when the next global pandemic hits https://go.nature.com/43X27wg
First global pandemic treaty agreed — without the US
The World Health Organization accord promotes sharing scientific data in exchange for more equitable distribution of drugs and vaccines.
go.nature.com
My first Saturday morning coffee on my deck this season 😎☕️
www.lemonde.fr/sciences/art...
Emmanuel Macron appelle les chercheurs internationaux à « choisir » la France et l’Europe, avec un « rendez-vous le 5 mai »
Avant ce rendez-vous, une plateforme baptisée « Choose France for Science » a été lancée jeudi par le gouvernement. Il la présente comme « une première étape pour préparer l’accueil des chercheurs int...
lemonde.fr
Intéressante tribune sur l'illusion d'une université française attractive pour les chercheurs américains tentés par l'exil. Ou de l'incapacité de regarder en face les conséquences de sa propre politique. Terrible absence de sens des responsabilités... www.lemonde.fr/sciences/art...
Accueillir les chercheurs américains en France , « une ambition louable, mais irréaliste »
TRIBUNE. L’universitaire Théo Besson rappelle, dans une tribune au « Monde », que le manque criant d’investissement ainsi que le niveau des salaires dans la recherche française interdisent de fantasme...
lemonde.fr
"The work we reviewed here supports an alternative view that the manifold and circuit approaches to cognition are inseparable." Can I get an amen? 😊 www.nature.com/articles/s41...
A unifying perspective on neural manifolds and circuits for cognition - Nature Reviews Neuroscience
Neural manifolds can shed light on how heterogeneous neuronal population activity drives neural computations, but linking these insights to the underlying neuronal connectivity is challenging. Engel a...
nature.com
"Quand Nicolas Demorand "révèle" qu'il souffre de trouble bipolaire de type 2, il ne dit rien de son affaire" 😡 En tant que psychiatre, je suis vraiment très en colère à la lecture de cet article de Charlie Hebdo de cette semaine. Un post n'est pas suffisant pour l'exprimer⬇️
