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Louis-Eric Trudeau

@louistrudeau.bsky.social

Neuroscientist. Dopamine et al. Parkinson's. Cyclist. Environmental activist who preaches by example. If it is to be, it is up to me. Knowledge is power, France is bacon.

197 Posts773 Follower592 Folgt
Louis-Eric Trudeau@louistrudeau.bsky.social · 2w ago

A new preprint from my lab, presenting work where we evaluated the impact of repeated exposure to pathogen-derived signals (LPS, Poly:IC) on brain inflammation and the dopamine system. Work supported by @asapresearch.parkinsonsroadmap.org www.biorxiv.org/content/10.6...

Repeated exposure to viral and bacterial danger signals in Parkin deficient mice induces inflammation but fails to trigger parkinsonism

Experimental models of Parkinson's disease (PD) traditionally involve direct perturbations of the functioning of dopamine (DA) neurons. However, PD is increasingly recognized as multifactorial in orig...

biorxiv.org

Louis-Eric Trudeau@louistrudeau.bsky.social · 4w ago

A manuscript that we published this past summer. This work was carried out in the context of our global objective to examine whether infections could represent a trigger of Parkinson's disease. @asapresearch.parkinsonsroadmap.org journals.plos.org/plospathogen...

A single Citrobacter rodentium infection in Pink1 knockout and wild-type mice leads to regional blood-brain-barrier perturbation and limited microglial activation without dopamine neuron axon terminal...

Author summary We hypothesize that immune system activation is linked to the development of Parkinson’s disease (PD). Previous work revealed that repeated gastrointestinal infections with Citrobacter ...

journals.plos.org

Exhausted in QC 🇨🇦@ninjazz636.bsky.social · 4mo ago

#Carney government passes law allowing authorization of banned pesticides—essentially allowing cabinet to overrule science. « We already have a pesticide regulatory system in place and it's there to protect people and protect the environment. » www.cbc.ca/news/politic...

Carney government passes law allowing authorization of banned pesticides | CBC News

The federal government has brought in major changes to how pesticides are regulated in Canada, granting cabinet the power to authorize the use of pesticides — even ones that Health Canada has deemed u...

cbc.ca

Louis-Eric Trudeau@louistrudeau.bsky.social · 6mo ago

Please check out our recent review on Parkinson's disease. The focus is on how cell-autonomous vulnerability factors and non-cell-autonomous triggers such as infections may interact to lead to neuronal loss. ASAP-supported work. @asapresearch.parkinsonsroadmap.org www.cell.com/trends/neuro...

Cell-autonomous and non-cell-autonomous drivers of dopamine neuron vulnerability in Parkinson’s disease

The motor symptoms of Parkinson’s disease are linked to age-dependent degeneration of dopamine neurons. Traditionally, the loss of these neurons has been thought to stem mainly from cell-autonomous ce...

cell.com

Katharina Schmack @kathaschmack.bsky.social · 6mo ago

🥁🎉The Psychosis Collective proudly presents our first preprint 𝐂𝐥𝐨𝐳𝐚𝐩𝐢𝐧𝐞 𝐬𝐮𝐩𝐩𝐫𝐞𝐬𝐬𝐞𝐬 𝐚𝐮𝐭𝐨𝐢𝐦𝐦𝐮𝐧𝐢𝐭𝐲 𝐝𝐫𝐢𝐯𝐢𝐧𝐠 𝐩𝐬𝐲𝐜𝐡𝐨𝐬𝐢𝐬-𝐥𝐢𝐤𝐞 𝐛𝐞𝐡𝐚𝐯𝐢𝐨𝐮𝐫 𝐢𝐧 𝐦𝐢𝐜𝐞 𝘈 𝘥𝘪𝘴𝘤𝘰𝘷𝘦𝘳𝘺 𝘫𝘰𝘶𝘳𝘯𝘦𝘺 𝘪𝘯 𝘵𝘩𝘳𝘦𝘦 𝘢𝘤𝘵𝘴 starring Le He & Harriet Feldman www.biorxiv.org/content/10.6... We wanted to understand how antipsychotics work. Thread🧵

Graphical abstract showing that NMDAR immunisation drives psychosis-like behaviour in mice, while clozapine reverses this. Upper panel: arrows show NMDAR immunisation producing a mouse exhibiting psychosis-like behaviour, with clozapine reversing this effect. Lower panels: anti-NMDAR antibodies bind neuronal NMDA receptors, which are then eliminated by microglia via phagocytosis, leading to psychosis. Clozapine restores NMDA receptor levels by reducing anti-NMDAR antibody levels, consistent with an immunomodulatory mechanism of action.
Ana Dorrego Rivas@adorrego.bsky.social · 8mo ago

The International Day of Women and Girls in Science is definitely one to celebrate. We have come a long way, and the future is bright and hopeful. But to get there, we need to keep acknowledging the systemic biases that sadly still exist nowadays 👇🏻

Université de Montréal - News@umontreal-en.bsky.social · 8mo ago

#ENERGY It's called AzoBiPy, it stores 2X the energy of most comparable molecules and is highly soluble in water — and that could make it a game-changer in the hunt for greener, safer batteries. @profrochefort.bsky.social #chemistry @jacs.acspublications.org nouvelles.umontreal.ca/en/article/2...

Saving sunny days for a rainy day: a new molecule for storing green energy

An UdeM-led research team has developed an organic molecule that stores renewable energy with record stability, paving the way for more sustainable flow batteries.

nouvelles.umontreal.ca

Pedaling Professor@pedalingprof.bsky.social · 8mo ago

This is Minneapolis. So damn proud of this place. Easily the largest group bike ride I've ever seen of people showing up for the Pretti-Good Memorial Ride. Huge thanks to all those who did logistical work, marshalled, and showed up for justice.

A giant MN state flag is attached to a bikeA giant puppet heart with hundreds of cyclists in the background A near endless stream of cyclists rides along a snowy parkwayA MN state flag flies over a crowd of cyclists
shaka 🦁👑@beejonson.me · 9mo ago

trump released the names of people who will "govern" and "rebuild" Gaza. White people in western liberal democracies, the same ones supporting israel, a white settler colonial apartheid ethnostate on its campaign of genocide and ethnic cleansing against Palestinians, get to decide who governs Gaza.