1/17 We are very happy to announce our latest work about the genetic origin and evolution of one of the most aggressive pediatric tumors: “Variable latency between the founder genetic event and rhabdoid tumor expansion” www.biorxiv.org/content/10.6.... Follow the thread to know more 👇

Variable latency between the founder genetic event and rhabdoid tumor expansion

Rhabdoid tumors are very aggressive rare pediatric cancers with poor survival affecting very young children. They are characterized by the bi-allelic loss of SMARCB1 or SMARCA4, which is suspected to ...

biorxiv.org

Co-leader Allan Balmain @ucsanfrancisco.bsky.social from the @cancergrand.bsky.social PROMINENT team gives an update on the latest findings published this week in @science.org which identify new opportunities for cancer prevention

Cancer Grand Challenges@cancergrand.bsky.social · 2mo ago

New findings from team PROMINENT in @science.org highlights new ways to think about cancer prevention by modulating clonal dynamics and ensuring that dangerous clones never emerge. Learn more: www.cancergrandchallenges.org/news/competi...

New findings from team PROMINENT in @science.org highlights new ways to think about cancer prevention by modulating clonal dynamics and ensuring that dangerous clones never emerge. Learn more: www.cancergrandchallenges.org/news/competi...

Major new work by the #TransCODE Consortium out today in @nature.com. Read all about our efforts to shed light onto the forgotten areas of the human proteome. #Microproteins #Peptideins #DarkProteome This was a huge global collaboration, in part funded via #NIH www.nature.com/articles/s41... 1/

Expanding the human proteome with microproteins and peptideins - Nature

A large-scale proteomics analysis of the dark proteome by the TransCODE Consortium reveals many translated non-canonical open reading frames to encode microproteins and peptideins.

nature.com

Tumor promotion through the lens of evolution This review grew out of many long conversations, shared ideas, and lively discussions It has been a real pleasure to think together with Allan, Paul, Eve, and Abel about how tumours develop and how carcinogens shape cancer risk rdcu.be/fdC2J

Tumour promotion through the lens of evolution

Nature - This Review revisits tumour initiation and promotion in light of clonal diversity and the presence of cancer driver mutations in normal tissues, aiming to understand mechanisms that enable...

rdcu.be

Meet our exceptional training team for #CancerEpi2026 💫 Field experts will guide you through how to use the best genomics tools and approaches to detect cancer mutations. 🗓️ 16-18 February 2026 Apply by 3 November - bursaries available 📎 bit.ly/41mRDnD #OncSky #GeneSky #CancerSky 🧪🖥️🧬

📢 Thrilled to share our latest paper, KDM6 Demethylases Contribute to EWSR1::FLI1-Driven Oncogenic Reprogramming in Ewing Sarcoma, from my PhD, is now published in Cancer Research! Explore our findings🔬🧬: aacrjournals.org/cancerres/ar... #Epigenetics #Cancer #EwingSarcoma Huge thanks to the team!

A short thread. For years, I have been surprised by how much confusion our discovery of clones carrying cancer-driver mutations in normal tissues has caused in the cancer community. Typical questions like: (1) if you see these mutations in normal cells, are they really cancer drivers?... [1/4]

Inigo Martincorena@imartincorena.bsky.social · 11mo ago

Our latest work is out in Nature today. In this paper, we introduce an improved version of NanoSeq, a duplex sequencing protocol with <5 errors per billion bp in single DNA molecules, and use it to study the somatic mutation landscape of oral epithelium in >1000 people www.nature.com/articles/s41...

Very excited to share our new paper on the influence of biological sex and smoking in the clonal landscape of normal human bladder, just published in Nature. A big thank you and congrats to all the authors, specially to @raquelbmi.bsky.social for all the shared efforts in this journey! ⬇️More info⬇️

Nuria Lopez-Bigas@nlbigas.bsky.social · 11mo ago

🚨 New paper alert! Sex and smoking bias in the selection of somatic mutations in human bladder www.nature.com/articles/s41... by @raquelbmi.bsky.social, @ferriol.bsky.social et al (in collaboration with Rosana Risques lab in @uwmedicine.bsky.social)

Scientists have used low-error genome-sequencing methods in normal tissues from large cohorts of individuals to scan for mutations that set the stage for cancer go.nature.com/42vakWS

Ultra-sensitive DNA sequencing maps mutations that precede cancer

Scientists have used low-error genome-sequencing methods in normal tissues from large cohorts of individuals to scan for mutations that set the stage for cancer.

go.nature.com

🧪 Out in @nature.com: Smoking and biological sex shape healthy bladder tissue evolution, offering clues to #cancer risk. ✍️ #IRBBarcelona & University of Washington ➡️ bit.ly/42wcIN5 📌 DOI: 10.1038/s41586-025-09521-x #IRBScience #CancerResearch #BladderCancer @bbglab.bsky.social 🧵👇

New research from team PROMINENT (@nlbigas.bsky.social), published in @nature.com, uncovers clues why men face a higher risk of bladder cancer and reveals that tobacco smoke acts as a promoter, not an initiator, in bladder cancer development. Read more: www.cancergrandchallenges.org/news/early-c...

Join us for hands-on training in Cancer Genomic Epidemiology! #CancerEpi2026 Gain the expertise to use the tools and approaches to detect cancer mutations, and inform equitable prevention. 🗓️ 16-18 February 2026 Apply by 3 November - bursaries available 📎 bit.ly/41mRDnD #OncSky #GeneSky 🧪🖥️🧬

New paper from our lab - ‪@bbglab.bsky.social‬. Oncodrive3D: fast and accurate detection of structural clusters of somatic mutations under positive selection academic.oup.com/nar/article/... Kudos to Stefano, Olivia, @fmuinos.bsky.social and Abel

Oncodrive3D: fast and accurate detection of structural clusters of somatic mutations under positive selection

Abstract. Identifying the genes capable of driving tumorigenesis in different tissues is one of the central goals of cancer genomics. Computational methods

academic.oup.com

Back after a few days in Lisbon for the annual #EACR2025 conference! Inspiring and great science. Glad for the opportunity to present our work, coming home with a bunch of new ideas! @bbglab.bsky.social @ferriol.bsky.social

Kudos to @raquelbmi.bsky.social and @ferriol.bsky.social, first authors of the study, for the insane amount of good work put into this.

We are searching for a Bioinformatics Software Developer to work in Cancer Genomics: recruitment.irbbarcelona.org/jobs/5793638...

Bioinformatics Software Developer in Cancer Genomics (ref. LAB/25/06) - IRB Barcelona

IRB Barcelona is seeking a talented and motivated Bioinformatics Software Developer (Research Assistant) to join the Biomedical Genomics Lab led by Dr. Núria López-Bigas at IRB Barcelona (bbglab.ir...

recruitment.irbbarcelona.org

🚀 Our new paper is out! The BioGenome Portal: an open-source customizable platform for managing biodiversity genomics data 🧬🌍 doi.org/10.1093/narg... @crg.eu @rodericguigo.bsky.social #genomics #biodiversity

The BioGenome Portal: a web-based platform for biodiversity genomics data management

Abstract. Biodiversity genomics projects are underway with the aim of sequencing the genomes of all eukaryotic species on Earth. Here we describe the BioGe

academic.oup.com

Will the world of short-read Next-Generation Sequencing change forever? We are about to find out! #Roche #SBX #ShortReads #NovaSeqKiller

“The leaders of the Human Genome Project always knew they were just starting a conversation” The human genome encodes potentially thousands of tiny proteins that were previously overlooked. The search is on to find out what they do https://go.nature.com/3CupmSS

‘Dark proteins’ hiding in our cells could hold clues to cancer and other diseases

The human genome encodes potentially thousands of tiny proteins that were previously overlooked. The search is on to find out what they do.

go.nature.com

📣 Two ERC-funded positions are available in the lab! If you are interested in exploring the mechanisms underlying mutation, we’d love to hear from you. PhD: shorturl.at/Oc04N Postdoc: shorturl.at/1ShHB RPs and shares would be greatly appreciated! 🧪🧬🖥️ #ScienceJobs #PostdocJobs

We recently announced a dual new release of intOGen and boostDM Computational analysis of 33,218 tumor genomes to identify cancer genes and driver mutations ➡️ Compendium of Cancer Driver Genes - www.intogen.org ➡️ In Silico Saturation Mutagenesis of Cancer Genes - www.intogen.org/boostdm