GAPDH is tethered to axonal transport vesicles by S-acylation https://www.biorxiv.org/content/10.64898/2026.09.17.752404v1

So happy to share our latest review on how post-translational modifications of SQSTM1, including S-acylation, regulate autophagy in neurodegeneration. www.tandfonline.com/doi/full/10....

Molecular switches of SQSTM1: the impact of post-translational modifications on autophagy and neurodegeneration

SQSTM1/p62 (sequestosome 1) is an important receptor protein involved in many cellular signaling processes, including macroautophagy/autophagy. It is a molecular hub for cellular homeostasis and ce...

tandfonline.com

Excited to share we identified an S-acylation motif & used it to develop a new S-acylation prediction program! @drssfs.bsky.social

SAPPTree: Identification of an S-Acylation Motif Drives a Novel S-Acylation Prediction Program

S-acylation, the reversible addition of fatty acids to proteins, has emerged as an abundant post-translational modification that drives protein localization and function. With no known consensus seque...

biorxiv.org

What an incredible turnout for @alscanada.bsky.social #WalkToEndALS at @uwaterloo.ca! 250-300 people came to raise funds & awareness for ALS. We hit our target & then some! Thank you to everyone who came out & @waterloosci for all your support! alscanadawalktoendals.als.ca/ontario2026/...

OK. Now for the pretty version of those muscle cells imaged on the confocal c/o @jesuisyasmeena.bsky.social

Very excited to share our preprint showing S-acylation (aka Palmitoylation) of TDP-43, VCP, SQSTM1, FUS & C9Orf72 in Huntington Disease (HD), Amyotrophic Lateral Sclerosis (ALS), & Multisystem Proteinopathy (MSP). This tour de force was led by @firyalrphd.bsky.social! www.biorxiv.org/content/10.6...

I defended my PhD 10 years ago today. That was the least remarkable thing that happened that day. Sharing something I wrote about it last year. Since then "the horrors persist but so do we." And with dignity.

Thrilled to share our recent review in @sfnjournals.bsky.social ALS and Huntington Disease: Unraveling the Connections between TDP-43 and Huntingtin. Here we discuss links between HD & ALS. Review & cover art come from the multitalented MSc student @cailyncreative.bsky.social tinyurl.com/57y6hjrd

Incredibly excited to share we're in Philly tonight to fete @firyalrphd.bsky.social who was a 2026 Uplifting Athletes Draft pick supported by Cure VCP Disease Inc. These awards support early career researchers studying rare diseases. Firyal is working developing genetic therapies for VCP disease.

I’m excited to be 1 of 10 researchers selected to receive a $20,000 grant from Uplifting Athletes and Cure VCP Disease! This grant will aid my research and ultimately help those impacted by #RareDiseases. Join me as #WeTackleRare at the Young Investigator Draft on Jan. 31! #YID26 bit.ly/yid2026

Attending "Roles and regulation of protein lipidation in health and disease" Day 1! #BiochemEvent @biochemsoc.bsky.social

Attending "Roles and regulation of protein lipidation in health and disease" Day 1! #BiochemEvent @biochemsoc.bsky.social