Shameful
Science Magazine@science.org · 3mo agoBreaking news: Indiana University plant microbiologist Roger Innes has been locked out of his laboratory by the school in response to a request by one of his federal funders. The move comes after Innes complained about the government’s prosecution of Chinese postdocs. https://scim.ag/4tsDqRr
And while we are on the subject of an uptick in ticks (see what we did there? *groans), here's an oldie but a goodie of a time when the worst thing CDC did to offend the public was putting ticks on muffins. www.usatoday.com/story/news/n...
CDC apologizes for hiding ticks on a poppyseed muffin to warn of Lyme disease threat
It's part of a CDC effort to warn Americans of tick-borne infections such as Lyme disease that the agency said are on the rise.
usatoday.com
Latest offering. How myelin ensheathes axons! Born from chat with Dwight Bergles on "weird things" we saw oligodendrocytes do, like making "bridges" between sheaths. Driven forward by Cody Call, Kelly Monk, and myelin folks @edinburgh-uni.bsky.social Enjoy! www.nature.com/articles/s41...
Flexible ensheathment of axons enables myelination of complex CNS networks - Nature
The rate of axon ensheathment varies within individual myelinating processes, resulting in chains of myelin sheaths connected by bridges consisting of thin cytoplasmic processes that provide ...
nature.com
New work from our team, led by the incredible @emily-hill.bsky.social out today @cp-neuron.bsky.social. Including some exciting additions from our prepint. Thread below! authors.elsevier.com/a/1ms0u3BtfH...
Over eight million Americans took to the streets today, which makes No Kings 3 the biggest single day of protest in the history of our country. #NoKings
Maggie Rogers, Joan Baez, and Tom Morello performing “The Times They Are A-Changin'”
Thanks to @elife.bsky.social for publishing this really nice insight article about my grad school paper! Absolutely thrilled that folks are excited about the work and the promise of microglia replacement. And yes I do still use these cells daily in my postdoc lab! elifesciences.org/articles/110...
Microglia: Replacing the immune system of the brain
A new method enables engineered immune progenitor cells to replace microglia in mice and reveals how a genetic mutation can lead to inflammation in the brain.
elifesciences.org
And now for some science
American Brain Foundation@abfbrain.bsky.social · 4mo agoRead about the recipients of the latest American Brain Foundation Cure One, Cure Many Awards in our latest blog! In the largest distribution of funding in ABF history, six researchers and their teams will study #neuroinflammation and #LewyBodyDementia. ⬇️ buff.ly/J98m8gY
I defended my PhD 10 years ago today. That was the least remarkable thing that happened that day. Sharing something I wrote about it last year. Since then "the horrors persist but so do we." And with dignity.
Rad paper alert!
Kelsey Nemec@kel-nem.bsky.social · 9mo ago📄🚨: Building off a stellar 2023 pub that engineered an hCSF1R variant, Sonia et al. now show how an mCSF1R variant not only confers inhibitor resistance and allows for efficient & non-toxic microglia replacement, but does so after vascular delivery into immunocompetent mice! 👏🧠 tinyurl.com/3wvmm8v3
Beautiful paper by @nicolecoufal.bsky.social . Check it out and the link to our N&V ( rdcu.be/eL8lM) expertly written by @chopresearch.bsky.social @pennmedresearch.bsky.social MSTP star Ryan Rahman.
Microglial MEF2C is a uniquely human bridge between neurodevelopment and neurodegeneration
Nature Immunology - Research identifies MEF2C as a human-specific switch that keeps microglia in balance. Loss of MEF2C tips microglia toward inflammatory and aging-like states that link to autism...
rdcu.be
Waggoner Lab@labwaggoner.bsky.social · 10mo agoTranscriptional and epigenetic targets of MEF2C in human microglia contribute to cellular functions related to autism risk and age-related disease @natimmunol.nature.com www.nature.com/articles/s41... @ucsandiego.bsky.social www.nature.com/articles/s41...
One of our best friends (non scientists) told us their kiddo is planning a school report on... microglia!!! We're sending a swag pack tomorrow and want to print out beautiful micrographs for their report -- want to get in on the action? Share your pretty pics!!!
A university that signs the “compact” is one that acknowledges its own inability to compete and succeed based talent and merit. It would signal insecurity and mediocrity to current and future students and faculty. Say no. Recruit the best people, protect their freedom and support their hard work.
Thrilled to share this work from my postdoc with Tom Carmichael, available online @ Neuron! Long story short: we find even more evidence that all reactive astrocytes are not equal, and we can take advantage of those differences to improve repair after stroke. www.sciencedirect.com/science/arti...
Regionally mapped astrocytic responses to cortical and white matter stroke show differential roles in astrocyte-induced vascular remodeling
Stroke is a major cause of disability. Astrocytes respond to stroke in a gradated manner, but details of that response and its consequences for tissue…
sciencedirect.com
Unrelated to anything, just a cool recent paper jamanetwork.com/journals/jam...
Acetaminophen Use During Pregnancy and Children’s Risk of Autism, ADHD, and Intellectual Disability
This nationwide cohort study with sibling control analysis examines the association of acetaminophen use during pregnancy with children’s risk of autism, ADHD, and intellectual disability.
jamanetwork.com
Three in two weeks. Could not be more proud of the newly minded Dr. Sameera Zia after successfully defending her PhD yesterday. This bright young star will do amazing things! Also, a huge thanks to @nachoriko.bsky.social for making the trip to Edmonton to serve as an external examiner
Joined the Advisory Board of @standupforscience.bsky.social alongside Viktor Ambros, @jeremymberg.bsky.social, Carol Greider, @michaelemann.bsky.social, & @katestarbird.bsky.social. Impressed with @cdelawalla.bsky.social and the entire Stand Up for Science team! www.standupforscience.net/cadres.
Cadres — STAND UP FOR SCIENCE
standupforscience.net
Calling all postdocs! Looking to enter the job market and gain hands-on experience with job talks & chalk talks? Apply to our NeuroYes Program @urneuroscience.bsky.social Neuroscience Commission NeuroYes 2025-2026 applications are open!!! Click on the link below to find out more! neuroyes.urmc.edu
She shouted along, asked what nearly every sign meant, greeted the police, told someone dressed like a founding father about the "golden rule", and agreed that "wooder" ICE is the most palatable Philly ice and butterflies are the only suitable orange monarch.
There are nearly 100,000 people at the rally in Philadelphia. #NoKings
It was a lot of fun co-writing this Spotlight with a talented graduate student @jingyiyang0321.bsky.social in my lab. Congrats to @fchrisbennett.bsky.social @nachoriko.bsky.social @waisenberg.bsky.social @Movahedi lab on these two important papers on microglia replacement! @cp-immunity.bsky.social
Jingyi Yang@jingyiyang0321.bsky.social · last yr.Hello world! My first post here, and it's a special one! I'm excited to share that my first piece of work in grad school titled "Microglia Replacement: From Monocytic Origin to Therapy" is now online in Trends in Immunology! Read it here: www.sciencedirect.com/science/arti...
Let’s get the word out about the importance of federal funding of curiosity -driven science We all have similar stories to share
Harvard Brain Science Initiative@harvardbrainsci.bsky.social · last yr.Protecting the Brain Requires Persistence @bethstevenslab.bsky.social, NIH-supported investigator of Alzheimer’s and other disorders, explains how one discovery can lead to another. news.harvard.edu/gazette/stor...
Check out this paper from the Movahedi lab! It’s a great companion to ours - showing the populations of brain macrophages that monocytes can replace. Congrats to first author Jonathan Bastos!
Immunity@cp-immunity.bsky.social · last yr.Online now: Monocytes can efficiently replace all brain macrophages and fetal liver monocytes can generate bona fide SALL1+ microglia
Our lab's 1st paper, led by @fchrisbennett.bsky.social & @waisenberg.bsky.social. A decade thinking how to directly assess the impact of microglia replacement. Yrs of hard work. This kind of work is needed to expand brain disease care for kids & the vision for safer, more effective cell therapy.
Immunity@cp-immunity.bsky.social · last yr.Online now: Direct microglia replacement reveals pathologic and therapeutic contributions of brain macrophages to a monogenic neurological disease
Emily Whitehead and her father on CNN with Jake Tapper speaking to the value of science. She is alive thanks to CAR T therapy developed at Penn and CHOP.
