together with an interview of @frengerquentin.bsky.social !! see there for details: journals.biologists.com/jcs/article/...

First person – Quentin Frenger

First Person is a series of interviews with the first authors of a selection of papers published in Journal of Cell Science, helping researchers promote themselves alongside their papers. Quentin Fren...

journals.biologists.com

SOLAR Mediates Lysosomal Membrane Repair and Redox Defense https://www.biorxiv.org/content/10.64898/2026.07.08.736954v1

CASM regulates p62/KEAP1/NRF2 antioxidant responses to lysosome damage https://www.biorxiv.org/content/10.64898/2026.07.08.736046v1

Please check out our new preprint! We find an unexpected role for #CASM in regulating p62 mediated activation of the KEAP1/NRF2 pathway to initiate a cytoprotective antioxidant transcriptional response. More functions for #CASM in responding to lysosome stress. www.biorxiv.org/content/10.6... 1/2

CASM regulates p62/KEAP1/NRF2 antioxidant responses to lysosome damage

Effective lysosome function is essential for health, and declines with ageing and disease. Upon lysosome damage, cells mount a complex stress response to restore homeostasis. Membrane ATG8ylation play...

biorxiv.org

Our Cell Scientist to Watch is Helene Knævelsrud @helene-knavelsrud.bsky.social. We spoke to Helene about her career, her research and her advice on mentorship. journals.biologists.com/jcs/article/... #autophagy #kidneycancer #mentorship #conferences #procrastination #advocacy #beer

Excited to be on my way to #GRCautophagy2026 to co-chair with @rushika-perera.bsky.social . But first the GRS! See you there

Are you headed to #GRC #Autophagy in Stress, Development and Disease next week, and interested in speaking with a JCB editor about publishing? Get in touch with our Executive Editor Tim Spencer, who will be there! ✉️ Email Tim: rupress.org/jcb/pages/ed...

I am looking for a post/doc! Are you motivated to study the fundamental questions in autophagy? Have a look!

We are pleased to welcome Prof Sir Jim Smith as the Institute's Interim Director. Read more 👇

Don't miss out on attending the Mar 15-20th 2026 GRC on #Autophagy in Ventura, California! All the latest findings from the field - check out the program and come tell us about your amazing science. www.grc.org/autophagy-in...

Don't miss out on hearing all the latest #autophagy discoveries at the 2026 GRC meeting in Ventura, US. We and the amazing line up of speakers look forward to meeting YOU 🫵. Follow link to register!!! www.grc.org/autophagy-in...

Check out the line up of amazing speakers at the 2026 GRC Autophagy meeting in Ventura, California, 15-20 March. Register now and share your latest findings. www.grc.org/autophagy-in...

Want to hear about the latest #autophagy discoveries? Join us in Ventura California for the 2026 GRC Autophagy meeting 15-20 March. Keynote speakers Sharon Tooze, Eileen White and Ivan Dikic. Registration open now⬇️ Bring your science! www.grc.org/autophagy-in...

a man in a tuxedo and suspenders is holding a baton and says science

ALT: a man in a tuxedo and suspenders is holding a baton and says science

media.tenor.com

Join us in sunny California for the 2026 GRC Autophagy meeting! Excited to co-chair with Oliver Florey and vice chairs Helene Knaevelsrud and @robzonculab.bsky.social Keynote speakers incl. Eileen White, @idikic.bsky.social and Sharon Tooze- Registration is open: link⬇️ www.grc.org/autophagy-in...

Last day in the lab for student Jake @jakecross96.bsky.social. So we had a naming ceremony for a freezer in his honor. Good luck at the @cellbiol-mrclmb.bsky.social

This will end up being another attack on research institutions in the US. I worked in New York on an H1 visa for many years. It benefited me and the lab I was in. Would it have happened if I cost an additional $100,000 per year? www.whitehouse.gov/presidential...

Restriction on Entry of Certain Nonimmigrant Workers

BY THE PRESIDENT OF THE UNITED STATES OF AMERICA A PROCLAMATION The H-1B nonimmigrant visa program was created to bring temporary workers into the United

whitehouse.gov

So, Farage wants to kick out my mum, a French citizen who has lived, worked, paid taxes and raised 2 kids in the UK for over 50 years. I'll make sure to yell at her to "go back to where you came from".

a man in a suit and tie is saying `` i have no words '' .

ALT: a man in a suit and tie is saying `` i have no words '' .

media.tenor.com

Don't know about him joining ICE.....

a man in a superman costume is holding up a metropolitan police mugshot .

ALT: a man in a superman costume is holding up a metropolitan police mugshot .

media.tenor.com

Another excellent study showing #CASM at play in plant stress responses!

Cell Biology J-Club@cellclub.bsky.social · last yr.

www.nature.com/articles/s41...

Neighbors may not like our overgrown lawn. But if it lets wild flowers like this grow, who cares! Bee Orchid #biodiversity

7 months later....BBSRC grant scored 6,6,5,4 (out of 6) - rated excellent. Committee D: Not funded.

a man wearing a tuxedo and bow tie is making a funny face .

ALT: a man wearing a tuxedo and bow tie is making a funny face .

media.tenor.com

Sometimes science can wait

Unbelievable. Richard Youle, winner of the Breakthrough Prize for Life Sciences, just got fired from the NIH. If you want to know what madness looks like, here it is, my friend.

WIRED@wired.com · last yr.

NEW: The doctor behind breakthrough Parkinson’s research was among the scientists purged from the National Institutes of Health, the US’s leading medical research agency. www.wired.com/story/doctor...

🚀Our latest work reveals how RAB5c orchestrates LC3-associated phagocytosis (LAP) to boost macrophage defense against A. fumigatus! 🦠🔬 🧵 Dive into the mechanisms linking endosomal traffic to innate immunity! #Immunology #Autophagy #Phagocytosis #Macrophage #Preprint doi.org/10.1101/2025...

RAB5c controls the assembly of non-canonical autophagy machinery to promote phagosome maturation and microbicidal function of macrophages

Non-canonical conjugation of ATG8 proteins, including LC3, to single membranes implicates the autophagy machinery in cell functions unrelated to metabolic stress. One such pathway is LC3-associated ph...

doi.org

bioRxivpreprint@biorxivpreprint.bsky.social · last yr.

RAB5c controls the assembly of non-canonical autophagy machinery to promote phagosome maturation and microbicidal function of macrophages https://www.biorxiv.org/content/10.1101/2025.03.25.645097v1

Congrats to Ian Ganley of Dundee University on winning the #BSCB Hooke Medal 🥇for his outstanding work on mitophagy 🎉🎉🌟

Happy to share the latest work from the lab @crick.ac.uk. Outstanding work from Di Chen and Tony Fearns showing the link between Mtb membrane damage, calcium leakage and ATG8/LC3 lipidation in macrophages. Congratulations Di and Tony! www.science.org/doi/10.1126/...

Mycobacterium tuberculosis phagosome Ca2+ leakage triggers multimembrane ATG8/LC3 lipidation to restrict damage in human macrophages

Ca2+ leakage triggers LC3 lipidation on multimembrane as Mtb phagosome damage response, independent of autophagy.

science.org

Twitter suffered an outage….. and I didn’t even notice.

a picture of a woman with the words i always found them irrelevant on it

ALT: a picture of a woman with the words i always found them irrelevant on it

media.tenor.com

American politics is a joke. With a chief joker. Heartbreaking for the world

I wonder when Trump will start referring to the Ukraine war as "the Russian humanitarian effort"

a puppet of donald trump sitting at a desk

ALT: a puppet of donald trump sitting at a desk

media.tenor.com

Honored to be involved with this event. Celebrating Len and Phill, titans of lipid signalling!

Babraham Institute@babrahaminst.bsky.social · last yr.

📢 Calling all Signallers! Join us for this celebratory smorgasbord of signalling research on 1-2 May with sessions on #proteostasis, #PI3K, #autophagy, #redox biology and #nuclear signalling. 🧪 Latest Institute research with special guests ⤵️ www.eventbrite.co.uk/e/cellular-s...