Registration is open for the upcoming GRC Autophagy in Stress and Disease - we have an amazing line up of speakers ! Come to sunny California ☀️ March 15-20 2026 #autophagy #cancer #aging #immunity #neurodegeneration #GRC www.grc.org/autophagy-in...

Join us in sunny California for the 2026 GRC Autophagy meeting! Excited to co-chair with Oliver Florey and vice chairs Helene Knaevelsrud and @robzonculab.bsky.social Keynote speakers incl. Eileen White, @idikic.bsky.social and Sharon Tooze- Registration is open: link⬇️ www.grc.org/autophagy-in...

Senior author @rushika-perera.bsky.social @ucsanfrancisco.bsky.social on latest publication suggesting new opportunities to treat pancreatic cancer, which is notoriously resistant to many therapies | Pancreatic Cancer Spreads to Liver or Lung Thanks to This Protein cancer.ucsf.edu/news/2025/06...

Online today in @nature.com - our latest study led by superstar postdoc Gilles Rademaker detailing the role of PSCK9 in driving sterol dependent metastatic organ choice in pancreatic cancer nature.com/articles/s41... full text available here 👉 rdcu.be/em0VG and thread 👇

I am thrilled to share that the first preprint from my lab is now available on bioRxiV! In this study, our team elucidates the role of autocrine ligands in the aberrant behavior of oncogene-driven lung cancer. www.biorxiv.org/content/10.1...

BRAFV600E-Driven Lung Tumorigenesis Requires Ligand-Mediated Activation of ERBB Receptor Signaling

Secretion of ligands of the human epidermal growth factor (EGFR) family of receptors or erythroblastic leukemia viral oncogene family (ERBB1-4) is a feature common to many cancer cells. However, our u...

biorxiv.org

👏 Congratulations to Dr. Edward Chang on his election to the National Academy of Sciences! Dr. Chang is the first neurosurgeon to achieve this prestigious distinction since Harvey Cushing's election more than 100 years ago in 1917! More about this historic recognition ➡️ ucsfh.org/438cefp

Wonderful talk by @rushika-perera.bsky.social of @ucsfhealth.bsky.social today in our @mti-ucb.bsky.social/#MolecularTherapeutics seminar series at @ucberkeleyofficial.bsky.social today, presenting cool data about organ-selective metastasis! Thank you!!!

SO excited to share that a major part of the postdoctoral work in @robzonculab.bsky.social lab is now published: “Leucine aminopeptidase LyLAP enables lysosomal degradation of membrane proteins” www.science.org/doi/10.1126/...

Leucine aminopeptidase LyLAP enables lysosomal degradation of membrane proteins

Breakdown of every transmembrane protein trafficked to lysosomes requires proteolysis of their hydrophobic helical transmembrane domains. Combining lysosomal proteomics with functional genomic dataset...

science.org

An incredible tour de force in biochemistry and cell biology by superstar @robzonculab.bsky.social lab postdoc @aakritijain.bsky.social LyLAP - a new lysosomal protease responsible for degrading integral membrane proteins in highly phagocytic cells like #PDAC cells. www.science.org/doi/10.1126/...

Leucine aminopeptidase LyLAP enables lysosomal degradation of membrane proteins

Breakdown of every transmembrane protein trafficked to lysosomes requires proteolysis of their hydrophobic helical transmembrane domains. Combining lysosomal proteomics with functional genomic dataset...

science.org

Fantastic talk today by the legend herself: so great to have her in house!! Don’t mind me while I fangirl over THE Dr. Rushika Perera! @rushika-perera.bsky.social @anirbanmaitra.bsky.social

☕️Kovalski et al. perform a genome-wide CRISPRi screen for selective MYC translation regulators and identify RBM42 as a ribosome-associated protein that modulates MYC translation and an #oncogenic mRNA program required for #PancreaticCancer growth. 👉🏼https://rdcu.be/ecb4e bit.ly/41FKwY3

Functional screen identifies RBM42 as a mediator of oncogenic mRNA translation specificity - Nature Cell Biology

Kovalski et al. perform a genome-wide CRISPRi screen for selective MYC mRNA translation regulators and identify RBM42 as a ribosome-associated protein that modulates translation of MYC and an oncogeni...

bit.ly

We are thrilled to share our discovery of a new factor, the RBP RBM42, which is key to fueling pancreas cancer through the deadly oncogene Myc. I look forward to what we uncover next! Thanks to the fantastic team lead by @DavideRuggero @rushika-perera.bsky.social & @genophoria.bsky.social!

Nature Cell Biology@natcellbio.nature.com · last yr.

☕️Kovalski et al. perform a genome-wide CRISPRi screen for selective MYC translation regulators and identify RBM42 as a ribosome-associated protein that modulates MYC translation and an #oncogenic mRNA program required for #PancreaticCancer growth. 👉🏼https://rdcu.be/ecb4e bit.ly/41FKwY3

Today we celebrate Zena Werb with an inspirational memorial lecture delivered by @carolynbertozzi.bskyverified.social who is a former UCSF Dept of Anatomy postdoc alum !

Doing my first cancer research #newPI rollcall on Bluesky! Please leave a comment with what you work on so I can follow you!

📢Please apply for the Cancer Discovery Early Career Award if you are the first or corresponding author of a Cancer Discovery paper published in 2023 or 2024, Assistant Professor or equivalent, and got your PhD/MD within the past 12 years! The deadline is January 10! aacrjournals.org/cancerdiscov...

Happy New Year. I’m pleased to report publication of the Ducker lab’s latest cancer metabolism paper led by graduate student Kyle Dunlap in @cp-cellreports.bsky.social www.cell.com/cell-reports.... 1/n

SLC7A5 is required for cancer cell growth under arginine-limited conditions

Metabolic adaptations are key to cancer cell survival in nutrient-limited microenvironments, but strategies for coping with arginine scarcity are poorly understood. Dunlap et al. use CRISPR screening and metabolomics to identify the plasma membrane transporter SLC7A5 as a citrulline transporter essential for cancer cell growth under arginine limitation.

cell.com

For those starting on BSKY and loving #metabolism and #mitochondria, the 2 starter packs have now been completed. 300 scientists working in this field are here to be followed! Happy Boxing Day Starter pack 1: go.bsky.app/VavECSX Starter pack 2: go.bsky.app/CH1MctZ

a stack of gift boxes with the words happy boxing day below

ALT: a stack of gift boxes with the words happy boxing day below

media.tenor.com

Good Sunday, all. What a wonderful collection of papers in #cancermetabolism and #mitochondrialbiology this is! Check it here: biomed.news/bims-camemi/... @biomednews.bsky.social Happy holiday season to you all! "Knowledge is an unending adventure at the edge of uncertainty."-Jacob Bronowski

bart simpson is talking to santa claus who is laying in a chair

ALT: bart simpson is talking to santa claus who is laying in a chair

media.tenor.com

Happy Saturday. If you're working on your NIH specific Aims for a February submission, don't include a figure. grants.nih.gov/grants-proce....

Congrats to Salma Merchant for Cell Stem Cell paper: the effects of fatty acid oxidation in hematopoietic stem cells are context dependent. FAO is not necessary in young HSCs, but becomes necessary during aging, and is deleterious when upregulated by a high fat diet. www.cell.com/cell-stem-ce...

Different effects of fatty acid oxidation on hematopoietic stem cells based on age and diet

Morrison and colleagues show long-chain fatty acid oxidation has context-dependent effects on hematopoietic stem cells (HSCs). It is dispensable for HSC function in young mice. It becomes necessary for normal HSC function and hematopoiesis in older mice. A high-fat diet increases fatty acid oxidation, and this impairs HSC function.

cell.com

@robzonculab.bsky.social lab representing at #CellBio2024 San Diego - great talks in the #Lysosome session by @hrshin.bsky.social @cri-utsw.bsky.social and @aakritijain.bsky.social 🙌 Lysosomes are amazing !

Now online in Cancer Discovery: Androgen Receptor Inhibition Increases MHC Class I Expression and Improves Immune Response in Prostate Cancer - by Lisa Chesner, Felix Feng, Amy Moran, and colleagues @ucsfcancer.bsky.social @ohsunews.bsky.social doi.org/10.1158/2159...

New NCI K32. Up to $80K for salary. $30K/yr research development. US citizenship NOT required. 🧪 grants.nih.gov/grants/guide...

Mike Feigin 🥯@mikefeigin.bsky.social · 2y ago

Well this is interesting. No more F32 at NCI. Replaced with K32. Anyone know why?

In case you missed it.. New preprint! Our latest study identifying how MHC-I is captured by autophagy and targeted for degradation in #PDAC - It all happens at the ER ! Congrats to co-first authors Marine Berquez, Alex Li & Matthew Luy. www.biorxiv.org/content/10.1...

A multi-subunit autophagic capture complex facilitates degradation of ER stalled MHC-I in pancreatic cancer

Pancreatic ductal adenocarcinoma (PDA) evades immune detection partly via autophagic capture and lysosomal degradation of major histocompatibility complex class I (MHC-I). Why MHC-I is susceptible to ...

biorxiv.org

🚨 New bioRxiv study! 🚨 PDAC adapts to glutamine depletion via macropinocytosis, reshaping CAF subtypes & tumor stroma. Blocking it sensitizes tumors to therapy. Shoutout to Dr. Yijuan Zhang for leading this amazing work! Read more: 🔗 www.biorxiv.org/content/10.1... #CancerResearch #PDAC #TME

Macropinocytosis controls metabolic stress-driven CAF subtype identity in pancreatic cancer

Pancreatic ductal adenocarcinoma (PDAC) tumors are deficient in glutamine, an amino acid that tumor cells and CAFs use to sustain their fitness. In PDAC, both cell types stimulate macropinocytosis as ...

biorxiv.org

Congratulations to the new #AACR #TME working group Chair elect!!! The one and only (best friend and colleague) @ashi-w.bsky.social www.aacr.org/professional...