We're happy to announce our new preprint! 🐸 easymode: general pretrained networks for cellular cryo-ET. Segment ~20 cellular features – ribosomes, microtubules, mitochondria, nuclei & more – with zero model training. 🔗 doi.org/10.64898/202... 🧵👇
Easymode: general pretrained networks for cellular cryo-ET enable flexible approaches to subtomogram averaging www.biorxiv.org/content/10.64898/2026.05.19.726344v1 #cryoEM
Happy to see our paper describing cryo-EM structures of the budding yeast KMN kinetochore complex published in @jcb.org! Our structure reveals how an important hub mediates and regulates assembly of the machine that segregates chromosomes. #cryo-EM @mrclmb.ac.uk 🔗 rupress.org/jcb/article/...
New Title Alert: easymode- a collection of general pretrained networks for cellular cryoET. Learn more here: buff.ly/mLbcUbZ #SBGrid #SBGridSoftware
easymode
buff.ly
We are thrilled to share our new pre-print on the molecular anatomy of nuclear proteasome in human sperm cells! #In-cellcryo-ET + #SPA + #LM! @piotrkolata.bsky.social @a-dsantos.bsky.social, @tomdendooven.bsky.social!! doi.org/10.64898/202...
Our latest work from the Venki Lab on translation initiation in endogenous circular RNAs is now available on bioRxiv! A great collaboration with Philipp Zuber (@zuber-phil15.bsky.social) and Xueyan Li!
bioRxiv Molecular Biology@biorxiv-molbio.bsky.social · 11mo agoMechanism of translation initiation on endogenous eukaryotic circular RNAs https://www.biorxiv.org/content/10.1101/2025.10.31.685782v1
Mechanism of translation initiation on endogenous eukaryotic circular RNAs https://www.biorxiv.org/content/10.1101/2025.10.31.685782v1
🚨 PostDoc opportunity at the MRC-LMB 🚨Join our team to explore transcription-coupled splicing using cryoEM and biochemistry! 🔬🧬 Please spread the news 🙏🏼 Apply here: mrc.tal.net/vx/mobile-0/... #Postdoc #CryoEM #MolecularBiology
MRC Laboratory of Molecular Biology@mrclmb.ac.uk · 2y agoWe’re looking for an enthusiastic #postdoc to join @suyangzhang.bsky.social’s group in the LMB’s Structural Studies Division, combining biochemical & structural approaches to investigate the mechanism of co-transcriptional splicing. www.nature.com/naturecareer... Apply by 21 APR #PostdocJobs #CryoEM
Ever wondered how transcription choreographs histone modifications? Our work reveals the basis of co-transcriptional H3K36me3 by SETD2. We visualize how a histone writer coordinates with the transcription machinery! This is the magnus opus of @jonmarkert.bsky.social! tinyurl.com/setd2
I have received a Wellcome Discovery Award to study the initiation of eukaryotic DNA replication, with 8 years of funding at the Francis Crick Institute. Looking for a postdoc in molecular mechanisms, cryo-EM, cryo-FIB and in situ structure? Contact me now! 3 postdoc positions advertised soon.
Here is a starter pack for CryoEM/ET enthousiasts To be completed go.bsky.app/JmQksC