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Alessandro Costa

@costalaboratory.bsky.social

Principal Group Leader at the Francis Crick Institute. DNA replication, cryo-EM and molecular mechanism.

35 Posts1023 Follower362 Folgt
Oxford Biochemistry @oxfordbiochemistry.bsky.social · 2mo ago

Today we celebrate our colleagues Colin Kleanthous and Rob Klose as they join the Fellowship of the Royal Society, one of the highest honours in the scientific world, in recognition of their impactful contributions to knowledge. Congratulations! 👏 👏 👏 Read more ⬇️

Congratulations to Colin Kleanthous and Rob Klose on joining the Fellowship of the Royal Society

The two scientists have been selected for outstanding contributions to their fields

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Lori Passmore@lapassmore.bsky.social · 5mo ago

Do you work on DNA or RNA protein complexes? 🧬 Come to Machines on Genes this June in Crete! ☀️ Super early discount is ending this Sunday so register now! 😃

Alessandro Costa@costalaboratory.bsky.social · 7mo ago

8–11 June 2026 | 📍 Heraklion, Crete 🇬🇷 Get ready for Machines on Genes 2026, the 94th Harden Conference by the @biochemsoc.bsky.social — four days of molecular mechanisms and friendly discussions! 🧬☀️🔬❄️ Organised by @lapassmore.bsky.social, Dana Branzei, me.

Alessandro Costa@costalaboratory.bsky.social · last yr.

Less than two weeks left to apply! Postdoc positions in my lab to study 1. initiation of DNA replication. 2. chromatin replication/epigenetic inheritance. Great for biochemists, biophysicists & structural biologists. Deadline 3 August 2025. crick.wd3.myworkdayjobs.com/External/job...

Postdoctoral Fellow - Costa Lab

Salary for this Role: From £45,500 with benefits, subject to skills and experience. Job Title: Postdoctoral Fellow - Costa Lab Reports to: Alessandro Costa Closing Date: 03/Aug/2025 23.59 GMT Job Desc...

crick.wd3.myworkdayjobs.com

Alessandro Costa@costalaboratory.bsky.social · 2y ago

How does ATP hydrolysis by MCM enable replicative helicase loading onto DNA? Find the answer in our latest article rdcu.be/d6D8D Congratulations to Agata Butryn who led the entire project, with contributions from Julia Greiwe at the start. 🎉❄️🔬🧬

Unidirectional MCM translocation away from ORC drives origin licensing

Nature Communications - When the MCM motor of the replicative helicase becomes loaded onto chromatin, origin DNA is licensed for replication. Here, the authors show why the ATPase function of MCM...

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Alessandro Costa@costalaboratory.bsky.social · 2y ago

I have received a Wellcome Discovery Award to study the initiation of eukaryotic DNA replication, with 8 years of funding at the Francis Crick Institute. Looking for a postdoc in molecular mechanisms, cryo-EM, cryo-FIB and in situ structure? Contact me now! 3 postdoc positions advertised soon.

Ferdos Abid Ali@abidalilab.bsky.social · 2y ago

If you’re interested in how molecular motors coordinate to power intracellular trafficking events (e.g. endocytosis), I’ve got a PhD position available to study this at vibrant Bristol uni. In this project, we will capture highly dynamic events by #cryoEM, single molecule imaging & cell biology. 🔬❄️🧪

This scheme shows the cargo adaptor FHF in the middle with arrows pointing to distinct microtubule and actin-based motors (dynein-dynactin, KIFC1, KIF1C and myosins V, IX and X as well as Tropomyosin 1). It also shows a link to Rab5 marked early endosomes. The hypothesis is that FHF coordinates multi motor binding at the early stages of endocytosis. The PhD project would address the hierarchy of motor binding and how these motors coordinate to allow the newly formed vesicle to transition from the actin to MT cytoskeletal network.