I am exciting to highlight our new study published today in @cp-neuron.bsky.social. This work represents over 6 years of effort by an incredibly talented postdoc, Carlos Diaz-Salazar, in collaboration with @krzischlab.bsky.social, @bhadurilab.bsky.social at UCLA and Mercedes Paredes lab at UCSF 👇 🧵
Human-specific SRGAP2 paralogs synchronize neotenic microglial maturation and synaptic development
Using a combination of microglia-specific conditional mouse knockout and knockin approaches and xenotransplantation of human iPSC-derived microglia, Diaz-Salazar et al. demonstrate that the human-spec...
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