Our preprint is now out in @natgenet.nature.com ! doi.org/10.1038/s415... We measured Sox2 promoter bursting dynamics with the SCR enhancer positioned at different distances within a genomic locus devoid of confounding effects in mESC: Main findings in the 🧵 below:

Enhancer control of promoter activity and variability via frequency modulation of clustered transcriptional bursts - Nature Genetics

Tünnermann et al. use live-cell imaging to study promoter activity under the control of an enhancer inserted at different genomic distances. RNA production from the promoter occurs in clusters of tran...

doi.org

Luca Giorgetti lab @FMI@lucagiorgetti.bsky.social · last yr.

Celebrating 10 years of our lab with a new preprint: www.biorxiv.org/content/10.1... How does enhancer location within a TAD control transcriptional bursts from a cognate promoter? Experiments by Jana Tünnermann and modelling by Gregory Roth

Is distal gene activation by enhancers inherently different from promoter-proximal activation? We propose not. But both cohesin and cooperativity are important aspects of how transcription is affected. Happy to share our recent preprint (thread below) 1/ www.biorxiv.org/content/10.6...

We have an open professor position at my institute, the Institute for Quantitative Biosciences, The University of Tokyo! www.iqb.u-tokyo.ac.jp/recruiting/2...

A High-Affinity Nanobody Recognizing mNeonGreen Enables Versatile Biochemical, Cellular, and in vivo Applications. by Steffen Frey and team: www.biorxiv.org/content/10.6...

Look forward to visiting IMP in Vienna on June 30 (Tue)!! www.imp.ac.at/calendar/eve...

Thanks Claudio @claudiocantu81.bsky.social and Silvia @remeseiro-lab.bsky.social for having me as a lecturer at the PALS Summer School. It was such a wonderful meeting!!

What a Start of the PALS Summer School in Transcriptomics with Prof. Silvia Nicolis @btbsunimib.bsky.social on Transcription factors in the brain and Prof. @fukayalab.bsky.social @utokyoofficial.bsky.social on enhancers imaging @remeseiro-lab.bsky.social @scilifelab.se @kawresearch.bsky.social

Claudio Cantù@claudiocantu81.bsky.social · 2mo ago

FINAL CALL! Register by the end of May to this year's edition 23-26 June 2026 Focus will OMICS data integration, with hands-on computation🧬 💻 Check out the program and your stellar teachers: www.trippus.net/summerschool... @scilifelab.se @kawresearch.bsky.social @remeseiro-lab.bsky.social

Excited to join the PALS Summer School as a lecturer! Looking forward to meeting and interacting with young students and researchers!! event.trippus.net/Home/Index/A...

We named three newly identified genes as boundary-associated factors! www.science.org/doi/10.1126/...

(1/n) Very excited to share tri-lab collab (Mirny & Zechner) led by Harvey, Henrik & Jack: Q: How do enhancers & promoters interact in space (contact vs. action-at-a-distance) and time (stable vs. transient)? A: Transient E-P contact (~25-42 nm lasting ~10-20 sec): www.biorxiv.org/content/10.6...

Looking forward to discussing our new studies at Karolinska Institute next Monday, June 22! news.ki.se/calendar/gue...

Guest seminar - Takashi Fukaya

Title: “Dynamics of ultra-long-range enhancer-promoter communication in early embryos”. Monday, June 22 at 10:30 in room D1012, Biomedicum.

news.ki.se

Huge thanks to Mounia @laghalab.bsky.social for a fantastic seminar! So many exciting unpublished stories!!

Excited to host Mounia Lagha (IGMM, Montpellier) @laghalab.bsky.social IQB on June 15 (Mon)! Everyone is welcome, including non-IQB members. Hope to see you there!!

Sad news - he certainly was a towering figure with many influential discoveries - see below. Why he was never awarded the 'big' prize is truly baffling, but his many contributions to science will be remembered much longer than any prize. Thank you @alexis-verger.cpesr.fr for putting this together.

Alexis Verger 🧬🧫🧪@alexis-verger.cpesr.fr · 3mo ago

#RIP Pierre Chambon (1931-2026) 1963 PARP 1970 RNA Pol II 1975 Nucleosome 1977 Split genes 1980 Promoter 1983 enhancer 1986 Nuclear receptor

www.youtube.com/watch?v=Nxtv...

Ohio Players. Sweet Sticky Thing

YouTube video by CJ'z GROOVE-A-THON

youtube.com

New preprint alert! Together with Tetsuya Yamamoto at Hokkaido University, we propose a “polymer micelle” model of transcriptional bursting. www.biorxiv.org/content/10.6...

www.youtube.com/watch?v=VRj8...

Numb (Live In - Studio Performance) / Shintaro Sakamoto (zelone official)

YouTube video by zelonerecords

youtube.com

Happy to have been part of the study! “Transient residence of the repulsive client Shutdown in Yb bodies plays a critical role in Piwi-piRISC biogenesis and maintaining fertility” www.cell.com/molecular-ce...

Transient residence of the repulsive client Shutdown in Yb bodies plays a critical role in Piwi-piRISC biogenesis and maintaining fertility

Hirakata et al. reveal that Shutdown rapidly returns from Yb bodies to the cytosol through its repulsive N-terminal property. This dynamic release enables piRNA maturation and safeguards fertility, pr...

cell.com

IQB seminar today! Open to everyone. Feel free to drop by!!

Takashi Fukaya@fukayalab.bsky.social · 4mo ago

Another seminar announcement! We are excited to host Hernan Garcia (UC Berkeley) at IQB on April 2nd (Thu). Everyone is welcome to join!!

Very much looking forward to it!!

Claudio Cantù@claudiocantu81.bsky.social · 4mo ago

Join 🇸🇪 🌞 The PALS Summer School in TranscriptOMICS To learn Enhancer dynamics in living Drosophila embryos by ⭐ prof Takashi Fukaya⭐ @fukayalab.bsky.social @utokyoofficial.bsky.social @kawresearch.bsky.social @scilifelab.se @remeseiro-lab.bsky.social REGISTER www.trippus.net/summerschool...

Another seminar announcement! We are excited to host Hernan Garcia (UC Berkeley) at IQB on April 2nd (Thu). Everyone is welcome to join!!

Excited to host Evgeny Kvon (UC Irvine) @evgenykvon.bsky.social at IQB on March 30 (Mon)! Everyone is welcome, including non-IQB members. Hope to see you there!! 来週3/30月曜に、UC IrvineのEvgeny Kvonさんのセミナーを開催します！定量研外からの参加もウェルカムですので、是非ご参加ください！！

Ever wondered how a eukaryotic transcription factor finds its specific DNA motif in the vast genome? In this preprint, we directly measured the dynamics of this search process in living cells, revealing a cooperative mechanism mediated by disordered regions. 1/10 doi.org/10.64898/202...

The Karolinska-UTokyo Joint PhD Course has wrapped up! It was a real pleasure serving as a course director and interacting with such talented students. Excited to see how your research grows from here!!

Thanks Ibrahim for stimulating talk and discussion!!

Diving into evolutionary biology! What is the origin of the most abundant class of insect transcription factors, ZAD-ZnFs? We suggest that they evolved from ancestral insulator-binding proteins that control 3D genome topology. www.science.org/doi/10.1126/...

Decoding the molecular logic of rapidly evolving ZAD zinc finger proteins in Drosophila

Identification of ZAD-ZnF genes as key regulators of genome organization during Drosophila embryogenesis.

science.org

We are excited to host Ibrahim Cissé (Director, Max Planck Institute of Immunobiology & Epigenetics) at IQB, on March 3 (Tue)!!

I am excited to share a new review @cp-molcell.bsky.social written in collaboration with @tanjamittag.bsky.social , Mikayla Eppert, and Ambuja Navalkar where we review the current evidence for and against the role of density transitions in regulating transcription www.cell.com/molecular-ce...

New preprint from the lab! We identify the ZnF protein Mulberry as a condensation-dependent structural regulator of genome topology that organizes “multi-way regulatory hubs” in early Drosophila embryos. www.biorxiv.org/content/10.6...

Terrific paper on a new chromosomal compartment where extensive loop extrusion isolates domains from other such domains

The EMBO Journal@embojournal.org · 6mo ago

How do compartmentalization & loop extrusion organize eukaryotic genomes beyond classical model organisms? Hi-C analysis of silkworm chromosomes by Drinnenberg, Muller, Mirny et al reveals new combination of these mechanisms, and a new, secluded “S” compartment link.springer.com/article/10.1...