Delighted to have been part of this study, out today in @cp-cell.bsky.social ! We identified a homeotic long non-coding RNA that modulates human HSCs and🩸cancer risk. Check it out! 👇

Vijay G. Sankaran@bloodgenes.bsky.social · 3mo ago

🚨 Excited to share a new paper in Cell! Human genetics led us to HOTSCRAMBL, a HOXA-locus lncRNA that regulates 🩸#stemcell self-renewal and HOXA9 splicing, with implications for AML. Amazing work by @lvchosen1.bsky.social with many others! www.cell.com/cell/fulltex...

What protects some people from leukemia? Thrilled to share my work at @bloodgenes.bsky.social lab, now published in @science.org. We identify an inherited genetic variant that protects stem cells from blood cancers by reducing risk of CHIP. t.co/ExgWIJQe6y 🧵👇(1/n)

Vijay G. Sankaran@bloodgenes.bsky.social · 7mo ago

Delighted to have our work on 🧬 resilience to 🩸cancer led by @g-agarwal.bsky.social & amazing collaborators, including @kharaslab.bsky.social, published in @science.org: www.science.org/doi/10.1126/... 🧵

Thank you so much for highlighting our work, @erictopol.bsky.social !!

Eric Topol@erictopol.bsky.social · 7mo ago

New @science.org today Discovery of a genomic variant that protects against blood cancer by reducing risk of CHIP (blood stem cell mutation clones, common with aging) @bloodgenes.bsky.social @kharaslab.bsky.social science.org/doi/10.1126/...

Enjoyed writing this commentary with @g-agarwal.bsky.social for @bloodjournal.bsky.social: ashpublications.org/blood/articl... Covers an exciting paper from Tapper and co: ashpublications.org/blood/articl... #mpnsm

Delighted to have our preprint led by @lvchosen1.bsky.social up: Genetic variation reveals a homeotic long noncoding RNA that modulates human hematopoietic stem cells biorxiv.org/content/10.1... 🧵 below ...

Grateful to have our research illustrated so beautifully by @atjcagan.bsky.social ! 🙏 Check out our work below, in which we describe inherited genetic resilience that protects some individuals from blood cancers 👇 www.biorxiv.org/content/10.1...

Inherited resilience to clonal hematopoiesis by modifying stem cell RNA regulation

Somatic mutations that increase hematopoietic stem cell (HSC) fitness drive their expansion in clonal hematopoiesis (CH) and predispose to blood cancers. Although CH frequently occurs with aging, it r...

biorxiv.org

Vijay G. Sankaran@bloodgenes.bsky.social · last yr.

Thrilled to see my #MITS25 talk brought to life by the brilliant 🎨 @atjcagan.bsky.social! Dive into the stellar science from @g-agarwal.bsky.social & co - fresh on bioRxiv: www.biorxiv.org/content/10.1... #Genomics #SomaticEvolution

Out today in @science.org! What if you could chart cells' regulatory programs at unprecedented resolution? In my work with Jorge Martin-Rufino from the @bloodgenes.bsky.social lab, we dissect the genome’s control circuits and find where key genetic variation hides bit.ly/3YhBMoO

Transcription factor networks disproportionately enrich for heritability of blood cell phenotypes

Most phenotype-associated genetic variants map to noncoding regulatory regions of the human genome, but their mechanisms remain elusive in most cases. We developed a highly efficient strategy, Perturb...

bit.ly

So proud of this incredible work from @g-agarwal.bsky.social from our group with help from many fantastic folks in our lab and inspiring collaborators, including @kharaslab.bsky.social, Alex Bick, @yashpershad.bsky.social, and many others! Please check out Gaurav's awesome 🧵👇👇

Gaurav Agarwal@g-agarwal.bsky.social · last yr.

What protects individuals from developing blood cancers? Thrilled to share my work in @bloodgenes.bsky.social lab, describing inherited resilience protecting blood stem cells from clonal hematopoiesis by modifying RNA regulation. 🧵👇 (1/n) www.biorxiv.org/content/10.1...

What protects individuals from developing blood cancers? Thrilled to share my work in @bloodgenes.bsky.social lab, describing inherited resilience protecting blood stem cells from clonal hematopoiesis by modifying RNA regulation. 🧵👇 (1/n) www.biorxiv.org/content/10.1...