Rather than being the product of a churning, molten core, Ganymede’s dynamo may be powered by a core that is still forming, researchers report. Learn more: https://scim.ag/4etP0rF

I am happy to share that Perturb-Multiome ATAC fragment files (www.science.org/doi/10.1126/...) are now available on our GEO repository. 🧬👩‍💻 👉 (www.ncbi.nlm.nih.gov/geo/query/ac...) #SankaranLab #Multiome #Perturbationscreen

What a beautiful work from my friend Peng Lyu in #SankaranLab, demonstrating how non-coding transcribed genetic information can rewire HSCs and modulate the risk to develop blood malignancies! www.sciencedirect.com/science/arti...

Genetic variation reveals a homeotic long noncoding RNA that modulates human hematopoietic stem cells

The HOXA gene locus coordinates body patterning, hematopoiesis, and differentiation. While studying blood phenotype-associated variation within the HO…

sciencedirect.com

Systemic inflammation impairs myelopoiesis and interferon type I responses in humans www.nature.com/articles/s41... @natimmunol.bsky.social

There’s an arms race going on between a disease-causing fungus and its host, and it’s not the one portrayed in HBO’s postapocalyptic series The Last of Us. #ScienceMagArchives scim.ag/42QS3Un

Arms race between ants and fungi has echoes of The Last of Us

Insects are fighting off fungal invaders, but the fungi have some tricks up their sleeve

scim.ag

The Science Visuals team has been honored with three @commarts.com Awards of Excellence. These prestigious awards recognize creative excellence and outstanding execution in visual storytelling. (THREAD 🧵) scim.ag/4jDJ6TY

Science Visuals honored with three Communication Arts Awards

The prestigious awards recognize creative excellence and outstanding execution in visual storytelling.

scim.ag

A great ressource from the Khoriaty lab at University of Michigan to understand deeper the molecular regulation of erythropoiesis, this week in @natcomms.nature.com www.nature.com/articles/s41...

A genome-wide screen identifies genes required for erythroid differentiation - Nature Communications

Using a genome-wide CRISPR knock-out screen, the authors defined the repertoire of genes that are required for proerythroblast survival and for terminal erythroid differentiation.

nature.com

Scalable spatial transcriptomics through computational array reconstruction - @broadinstitute.org go.nature.com/3QYfSDd

Scalable spatial transcriptomics through computational array reconstruction - Nature Biotechnology

An imaging-free spatial transcriptomics method facilitates high-throughput barcode array generation up to centimeter scale.

go.nature.com

Our work nicely complements recently released papers from @thenormanlab www.cell.com/cell-systems... and @satijalab www.nature.com/articles/s41... that describe the value of multimodal perturb-seq using CRISPRi in cell lines to decipher gene regulatory networks ! 🧬 🧫

Out today in @science.org! What if you could chart cells' regulatory programs at unprecedented resolution? In my work with Jorge Martin-Rufino from the @bloodgenes.bsky.social lab, we dissect the genome’s control circuits and find where key genetic variation hides bit.ly/3YhBMoO

Transcription factor networks disproportionately enrich for heritability of blood cell phenotypes

Most phenotype-associated genetic variants map to noncoding regulatory regions of the human genome, but their mechanisms remain elusive in most cases. We developed a highly efficient strategy, Perturb...

bit.ly

Congratulations to @danafarber.bsky.social’s Lara Wahlster, MD, PhD, and Nina Weichert-Leahey, MD, for receiving the American Society for Clinical Investigation Emerging-Generation Awards. Read about Dr. Wahlster at bit.ly/4haxdTW and Dr. Weichert-Leahey at bit.ly/4h6BYxL.