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Vijay G. Sankaran

@bloodgenes.bsky.social

Pediatric Hematologist/Oncologist, Geneticist, Stem Cell Biologist bloodgenes.org

299 Posts3463 Follower1282 Folgt
Mick Milsom@milsommick.bsky.social · 6d ago

New publication from the groups of Duncan Odom, Marieke Essers and myself: Concentrating cell-type-specific transcriptional signatures in bone marrow from interspecies comparisons: Cell Genomics www.cell.com/cell-genomic... @dkfz.bsky.social

Concentrating cell-type-specific transcriptional signatures in bone marrow from interspecies comparisons

The authors present a framework to isolate condensed marker gene signatures by requiring both conserved cell-type specificity and conserved expression across multi-species scRNA-seq datasets. Bone mar...

cell.com

Vijay G. Sankaran@bloodgenes.bsky.social · last wk.

🩸🧬 Delighted to share our new @nature.com paper! Genetic studies of >28,000 people reveal a BACH2-NRF2 pathway for activating fetal hemoglobin, suggesting new tx avenues for sickle cell disease & β-thalassemia. Led by the amazing Chun-Jie Guo & co! www.nature.com/articles/s41...

Human genetics implicates a BACH2–NRF2 axis in fetal haemoglobin activation - Nature

BACH2 restrains activation of the fetal-haemoglobin-encoding γ-globin genes, while loss of BACH2 enhances NRF2 chromatin occupancy and promotes the formation of activation foci at the γ-globin genes.

nature.com

Vijay G. Sankaran@bloodgenes.bsky.social · 2mo ago

🚨👇 Check out this wonderful collaborative work identifying a new 3D genome regulator - Matchmakers - with the incredible @andersshansen.bsky.social ! Fantastic work led by Varshini Ramanathan and Chun-Jie Guo!

Anders Sejr Hansen@andersshansen.bsky.social · 2mo ago

(1/n) Excited to share close collab w @bloodgenes.bsky.social led by Varshini & Chun-jie et al How to induce expression of key genes while silencing much of the genome during Erythropoiesis? A: Matchmaker CREs load cohesin near key genes to promote looping & exp: www.biorxiv.org/content/10.6...

Jayati Sharma, PhD, ScM@jayatirsharma.bsky.social · 3mo ago

In what has been a labor of love & joyful collaboration, we are super excited to share our preprint on recommendations towards the ethical and accurate use of population descriptors generated from a survey by trainees, for trainees. www.biorxiv.org/content/10.6...

Recommendations for the ethical and accurate use of population descriptors: a trainee-led survey of early-career researchers

Despite the importance of population descriptors in human genomics research, many scientists struggle to translate evolving ethical guidelines into their computational workflows. To characterize this ...

biorxiv.org

Vijay G. Sankaran@bloodgenes.bsky.social · 4mo ago

🙏 Deeply honored to receive the 2026 Warren Alpert Prize! This award reflects the work by so many to enable transformative therapies for sickle cell disease and thalassemia, and the power of human genetics to reveal biology and guide new treatments! hms.harvard.edu/news/2026-wa...

2026 Warren Alpert Foundation Prize Awarded for Gene-Editing Therapies

Five scientists recognized for contributions to cures for sickle cell disease and beta-thalassemia

hms.harvard.edu

Angelo D’Alessandro@dalessandrolab.bsky.social · 4mo ago

Now out in Blood @ash.hematology.org @bloodjournals.hematology.org ashpublications.org/blood/articl... Really proud of this one, and grateful to the reviewers for the constructive criticism. It really is a much better paper now!

The red blood cell proteome and interactome identify a Band 3-BLVRB axis regulating hypoxic metabolic adaptation

Key Points. Deep proteomics defines a complete, contamination-free RBC proteome (3,775 proteins) and O2-dependent interactome by Xlinking proteomicsThe Ban

ashpublications.org

Angelo D’Alessandro@dalessandrolab.bsky.social · 10mo ago

Labor of love announcement: Red blood cells make up 83% of the cells in the human body. Mature RBCs lack nuclei (no gene expression) and organelles, and >90% of their dry weight is hemoglobin. Yet we have lacked a clean, contamination-free map of their proteome. Until now. doi.org/10.1101/2025...

Jonathan Pritchard@jkpritch.bsky.social · 4mo ago

Combined Optical Pooled Screens and Perturb-seq! Great new work by Romain Lopez & Taka Kudo. This is one of a series of papers from our lab (here, with Aviv Regev) using perturbations to interpret human genetics; a key revelation for me is how transferable the mouse perturbs are to human genetics.

Romain Lopez@biologicalml.org · 4mo ago

🚀 We are introducing PerturbPair (with Taka Kudo) — a platform that combines parallel Perturb-seq and optical pooled screening (PerturbView) in primary cells to systematically map at massive scale how genetic perturbations reshape cellular states across modalities. www.biorxiv.org/content/10.6...

Adam Sperling, MD, PhD@adamssperling.bsky.social · 5mo ago

Excited that our paper describing a phase 1 trial of ducabtagene autloeucel, a rapidly manufactured anti-BCMA CAR-T in r/r multiple myeloma, was published. #ScienceTranslationalMedicine Huge thanks to all my co-authors, the teams at @danafarber.bsky.social and Novartis, and to our patients.

Efficacy and safety of durcabtagene autoleucel in a phase 1 trial for patients with relapsed/refractory multiple myeloma

Durcabtagene autoleucel, a rapidly manufactured BCMA-directed CAR T cell therapy, was safe and efficacious in relapsed/refractory multiple myeloma.

science.org

Vijay G. Sankaran@bloodgenes.bsky.social · 5mo ago

I had such a wonderful time joining @stemcellpodcast for this conversation! It was a real pleasure to discuss how human genetics can illuminate 🩸 stem cell biology, hematopoiesis, and opportunities to develop better therapies. Thanks so much for having me!

Stem Cell Podcast@stemcellpodcast.com · 5mo ago

📢 Our next episode is out! Tune in to hear Dr. Vijay Sankaran (@bloodgenes.bsky.social) at the Harvard Stem Cell Institute discuss how his lab uses human genetics and stem cell biology to uncover mechanisms regulating #hematopoiesis and blood disease! 🎙️ https://bit.ly/4tWDOI3

Molly Przeworski@mollyprz.bsky.social · 5mo ago

Happy to highlight new findings by Vanesa Getseva and Lin Poyraz about the sources of variation in germline mutation rates among humans: www.biorxiv.org/content/10.6... Joint work with Anastasia Stolyarova and @ipsitaagarwal.bsky.social. 1/n

A sibling study of variation in parental mutation rates

People are born with variable numbers of de novo germline mutations (DNMs), depending primarily on the ages of their parents. To explore additional causes, we developed an approach to call DNMs from nucleotide differences between siblings in genomic regions inherited identical by descent from both parents. Applying it to whole genome sequences from 28,985 sibling pairs of diverse genetic ancestries present in the UK Biobank and All of Us datasets, as well as 2,330 trios, we identified >800K autosomal DNMs and characterized mutation phenotypes in 27,645 sets of parents. We found subtle shifts in the mutation spectrum but no differences in total DNM rates among genetic ancestry groups, or between smokers and non-smokers. Testing for associations between parental mutation phenotypes and their burden of loss-of-function and deleterious missense variants in a set of 180 DNA repair and maintenance genes, we discovered that disruptions in REV1 and LIG1 increase germline mutation rates, and thus that rare mutator alleles segregate in population cohorts. ### Competing Interest Statement The authors have declared no competing interest. NIH, R35 GM083098

biorxiv.org

Vijay G. Sankaran@bloodgenes.bsky.social · 5mo ago

Wonderful to spend time hiking with our incredible team! Grateful for this remarkable group and inspired every day by their creativity, dedication, kindness, and teamwork - both in and outside the lab. 🩸🧬

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Richard Sever@richardsever.bsky.social · 6mo ago

Saddened to learn of the death of Greg Hannon, a former CSHL colleague and giant of modern molecular biology www.cruk.cam.ac.uk/news/in-memo...

In Memoriam: Professor Greg Hannon (1964–2026) - Cancer Research UK Cambridge Institute

Greg was already a world-renowned scientist when appointed Director, and for the community, he was a visionary leader, a cherished mentor, and a singular force of nature whose influence shaped the research landscape.

cruk.cam.ac.uk