An integrated single-nucleus and spatial transcriptomics atlas reveals the molecular landscape of the human hippocampus - Nature Neuroscience

The topographical organization of cells in the hippocampus reflects its ability to regulate mood and cognition. Here the authors generate a spatially resolved gene expression map in the human hippocam...

nature.com

LSD's rapid antidepressant effects are modulated by 5-HT2B receptors

Recent clinical trials show that serotonergic psychedelics, including the prototypical hallucinogen lysergic acid diethylamide (LSD), possess a great …

sciencedirect.com

Intracranial directed connectivity links subregions of the prefrontal cortex to major depression - Nature Communications

Low frequency brain waves convey information between regions. Here, the authors demonstrate that for patients with major depression, mood becomes more negative as low frequency waves increase intensit...

nature.com

Stress-responsive neuronal ensembles and β-adrenergic signaling in the basolateral amygdala modulate the infra-limbic cortical activity and govern the delayed stress-induced fear extinction deficit.

Stress is a critical risk factor for the development of psychological disorders, including anxiety and post-traumatic stress disorder (PTSD). Key brain regions, including the basolateral amygdala (BLA...

jneurosci.org

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Understanding Psychedelics and Neuroplasticity with Robin Carhart-Harris, PhD

Psychedelic Medicine Podcast with Dr. Lynn Marie Morski · Episode

open.spotify.com

Enhanced Rap1 small GTPase activity in the ventral hippocampus drives stress-induced anxiety

Chronic stress activates Rap1 in vHPC PNs to promote anxiety-like behaviors by increasing their intrinsic excitability.

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Acute subjective effects of psychedelics in naturalistic group settings prospectively predict longitudinal improvements in trauma symptoms, trait shame, and connectedness among adults with childhood m...

Studies of psychedelic use in naturalistic and clinical settings have suggested safety and mental health benefits for adults with histories of childho…

sciencedirect.com

Single-dose DMT reverses anhedonia and cognitive deficits via restoration of neurogenesis in a stress-induced depression model

Major depressive disorder (MDD) remains a leading cause of disability worldwide, with current treatments limited by delayed onset and low efficacy. The serotonergic psychedelic N,N-dimethyltryptamine ...

biorxiv.org

Neuromodulatory signaling contributing to the encoding of aversion

The appropriate and rapid encoding of stimuli bearing a negative valence enables behaviors that are essential for survival. Recent advances in neuroscience using rodents as a model system highlight th...

cell.com

GrimACE: Automated, multimodal cage-side assessment of pain and well-being in mice

Pain and welfare monitoring is essential for ethical animal testing, but current cage-side assessments are qualitative and subjective. Here we present the GrimACE, the first fully standardised and aut...

biorxiv.org

Astrocytic cannabinoid receptor 1 promotes resilience by dampening stress-induced blood–brain barrier alterations - Nature Neuroscience

The mechanisms of neurovascular adaptations underlying stress resilience remain unclear. Here the authors show that the astrocytic endocannabinoid system modulates the blood–brain barrier changes duri...

nature.com

Coding principles and mechanisms of serotonergic transmission modes - Molecular Psychiatry

Molecular Psychiatry - Coding principles and mechanisms of serotonergic transmission modes

nature.com

Cortical representations of affective pain shape empathic fear in male mice - Nature Communications

The neural basis of affect sharing is not fully understood. Here, the authors show that the anterior cingulate cortex (ACC) stably recruits neural ensembles encoding observational fear, specifically r...

nature.com

Cultivating allyship for a diverse, equitable and inclusive academia - Nature Human Behaviour

We propose six actionable steps of allyship that researchers, faculty members and educators can engage in to foster a diverse, equitable and inclusive academia: listening to marginalized voices, challenging one's own biases, speaking up to include disadvantaged groups, speaking out to confront bias, advocating for inclusive policies and dismantling institutional biases.

go.nature.com

Circuit organization of the rodent medial prefrontal cortex

The prefrontal cortex (PFC) orchestrates higher brain function and becomes disrupted in many mental health disorders. The rodent medial PFC (mPFC) possesses an enormous variety of projection neurons a...

cell.com

Integrating the environmental and genetic architectures of aging and mortality - Nature Medicine

Based on a systematic analysis of environmental exposures associated with aging and mortality in the UK Biobank, the relative contributions of such exposures and genetic risk for mortality and a range...

nature.com

Developmentally distinct architectures in top–down pathways controlling threat avoidance - Nature Neuroscience

Through circuit dissection in juvenile, adolescent and adult mice, Klune, Goodpaster and colleagues reveal multiple developmental switches in mPFC–NAc and mPFC–BLA pathways that underlie developmental...

nature.com

A dual-pathway architecture for stress to disrupt agency and promote habit - Nature

Adaptive decision-making often requires an understanding of our agency in a situation; however, chronic stress can disrupt agency and promote inflexible, habitual behaviour by turning off a brain path...

nature.com

Contribution of an under-recognized adversity to child health risk: large-scale, population-based ACEs screening

Background and Objectives Whereas adverse early life experiences (ACEs) correlate with cognitive, emotional and physical health at the population level, existing ACEs screens are only weakly predictiv...

medrxiv.org

Atypical hippocampal excitatory neurons express and govern object memory - Nature Communications

Pyramidal cells are classically thought to comprise the excitatory output of the subiculum. Here, the authors show the existence of “ovoid cells”, excitatory subiculum neurons with specialized gene ex...

nature.com