John Murray
@jisaacmurray.bsky.social
Associate Professor of Genetics, University of Pennsylvania. Genomics of development, gene regulation, C. elegans.
The International C. elegans meeting #worm27 is going to Kobe, Japan in 2027! genetics-gsa.org/celegans/ Organizers: Erik Andersen @erikandersen.bsky.social, Johns Hopkins University Kavita Babu @kavita-babu.bsky.social, IISc Bangalore Suhong Xu, Zhejiang University @genetics-gsa.bsky.social
Now published in @natcomms.nature.com
Colin Conine@colinconine.bsky.social · last yr.The first C. elegans paper from lab! We find that, similar to mammals, tRNA-fragments (or the new name in the field tDRs) accumulate in worm sperm and can transmit non-genetically inherited phenotypes to offspring. We also find an RNase that regulates their processing, showing that length matters
“CELeidoscope: quad-fluorescent strain for tissue-specific spectral single-cell analyses”. Engineered a C. elegans strain that enables spectral sorting of multiple major cell types within a single strain population. Led by Clair Henthorn and Natalia Betancourt. www.biorxiv.org/content/10.6...
David Botstein, a titan within the scientific community, died last week. GSA mourns his passing and celebrates his legacy. Read more about his significance to our community in this thread ⬇️🧵
Extra “kudos” to those who caved pre-emptively to this now defunct directive
ACLU@aclu.org · 6mo agoBREAKING: The Department of Education has ended its directive that attempted to restrict diversity, equity, and inclusion efforts in schools nationwide. This is a victory for academic freedom and education equity.
Very excited to share our very exciting story on how misinherited chromatin affects individual cells to cause a behavior defect in C. elegans (a thread👇) www.pnas.org/doi/10.1073/...
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
pnas.org
The Vahedi Lab is seeking a highly motivated Research Specialist A/B to join our dynamic research group studying the mechanisms of immune regulation. Apply here: wd1.myworkdaysite.com/recruiting/u...
Research Specialist A/B
University Overview The University of Pennsylvania, the largest private employer in Philadelphia, is a world-renowned leader in education, research, and innovation. This historic, Ivy League school co...
wd1.myworkdaysite.com
highlight of two recent fantastic comparative inter-species single-cell atlases, by @live-large.bsky.social from @jisaacmurray.bsky.social, and Itai Toker from Oliver Hobert's lab www.sciencedirect.com/science/arti...
Evolution of nervous systems: Molecular divergence in a conserved body plan
Comparative inter-species single-cell atlases of Caenorhabditis whole embryos and larval nervous systems reveal deep conservation of cell type identit…
sciencedirect.com
Worm25 has been absolutely fantastic so far-congrats to everyone for your amazing work! One striking change in the talks this year is it seems like the consensus number of neurons in the adult hermaphrodite has returned to 302 after a few years at 300. Is CAN back?
Despite all that is going on, we are still all working on our science. Our 2nd collaboration with @jisaacmurray.bsky.social and Bob Waterston (UW) is out: Lineage-resolved analysis of embryonic gene expression evolution in C. elegans and C. briggsae | Science www.science.org/doi/10.1126/...
Lineage-resolved analysis of embryonic gene expression evolution in C. elegans and C. briggsae
The constraints that govern the evolution of gene expression patterns across development remain unclear. Single-cell RNA sequencing can detail these constraints by systematically profiling homologous ...
science.org
Different species, same cell lineage, some gene expression patterns changed, others not so much…lots to dig into here! From @jisaacmurray.bsky.social lab
Sciences@sciences.skyfleet.blue · last yr.Lineage-resolved analysis of embryonic gene expression evolution in C. elegans and C. briggsae | Science
Happy to announce our paper comparing embryonic gene expression between C. elegans and C. briggsae, work led by Christopher Large with Rupa Khanal and in collaboration with Junhyong Kim and Bob Waterston. www.science.org/doi/10.1126/...
Lineage-resolved analysis of embryonic gene expression evolution in C. elegans and C. briggsae
The constraints that govern the evolution of gene expression patterns across development remain unclear. Single-cell RNA sequencing can detail these constraints by systematically profiling homologous ...
science.org
After 5 years, our team has a new telomere-to-telomere gap-free reference genome for C. elegans. We published our first results in 2019; I thought we'd have our loose ends wrapped up by spring 2020. That prediction was ... slightly off. But here's the genome now! www.biorxiv.org/content/10.1...
CGC1, a new reference genome for Caenorhabditis elegans
The original 100.3 Mb reference genome for Caenorhabditis elegans , generated from the wild-type laboratory strain N2, has been crucial for analysis of C. elegans since 1998 and has been considered co...
biorxiv.org
My first Bluesky paper post! I’m pleased to announce the publication of our single-nucleus atlas of adult neurons from wild-type and long-lived, better performing insulin receptor (daf-2) mutants, by Jon St. Ange and Yifei Weng et al.DOI: 10.1016/j.xgen.2024.100720
New paper ALERT!! Mara Cowen, PhD discovered and defined how conserved autism-associated genes modify a 'social' behavior in C. elegans!! So proud of her work in the lab! www.nature.com/articles/s41...
Conserved autism-associated genes tune social feeding behavior in C. elegans - Nature Communications
C. elegans aggregate in large clumps during feeding. Here, the authors find conserved autism-associated genes mediate distinct molecular and circuit signaling components that tune C. elegans feed...
nature.com
A reminder for new folks. BlueSky does not have an algorithm to raise posts of interest. It is incumbent upon you to do so via reposting. Liking things only provides feedback to the poster but does not promote the post. The signal to noise ratio is taking a brief beating, so great to help curate.
